For people with persistent eye problems due to Bartonella that are not resolving with antibiotics
by Greg Lee

When I was in Middle School, we were taught archery in physical education. I enjoyed learning how to hold, aim, and shoot arrows at a target many yards away. Part of our grade was seeing how close we could come to getting an arrow in the center bull’s-eye of the target. I am amazed at how no one got hurt with over twenty adolescent boys and girls shooting arrows all over the place.

How is archery target practice similar to a Bartonella eye infection?

Similar to getting an arrow in the bull’s-eye of the target, Bartonella has a similar way of impacting the eye
Andie’s eye felt hot, swollen, painful and itchy for many weeks. Warm compresses helped to temporarily relieve her symptoms. Her primary care doctor diagnosed her with conjunctivitis and gave her antibiotics, which did not help at all. Ice felt good, however the symptoms would return quickly. People can have chronic eye pain, swelling, and pressure that is related to a Bartonella henselae and quintana infection¹. Andie’s other symptoms indicated a possible Bartonella infection.

Bartonella can also produce symptoms of brain fog, burning in the extremities, and increased anxiety²
Given Andie’s other symptoms of brain fog, anxiety, and numbness, pain, and heat in her extremities, she was suspected of having a Bartonella co-infection. After 4 weeks of up and down painful eye symptoms, she decided to visit a Lyme literate acupuncturist. Fortunately, she was able to receive multiple treatments aimed at relieving her eye pain and inflammation.

There are multiple treatments that can treat a Bartonella eye infection
At the beginning of her appointment, Andie’s eye discomfort was at a level of 6 out of 10. One of the challenges is how to safely kill off an infection without damaging the eye. Fortunately, Frequency Specific Microcurrent uses minute amounts of electricity to kill infections, detoxify, and is a very safe.

Tx #1: Frequency Specific Microcurrent
Frequency Specific Microcurrent uses two pairs of frequencies which can be used to target infections like Bartonella anywhere in the body³. Andie received multiple pairs of frequencies in a single treatment. The first set of frequencies were used to kill Bartonella, neutralize bacterial toxins, and general toxins. The second set of frequencies were used to direct the microcurrent to the eye, rectus muscles, oblique muscles, eye socket, and eyelid. Electrical leads were placed on the back of her neck and over her eyes.

Result > After fifty minutes, her discomfort level decreased from 6 to 4 of 10

Next, acupuncture was used to aid in detoxification, reducing inflammation, and strengthening the immune system.

Tx #2: Acupuncture
Acupuncture points on the spleen and lung pathways were used to relieve inflammation, aid in detoxification, and support the immune system in fighting infection. As Andie’s acupuncture pulses improved, she was treated with laser delivered homeopathics.

Tx #3: Laser Delivered Homeopathics
A homeopathic remedy for treating Bartonella in a clear glass vial was used in combination with a 650 nm laser to treat Andie’s eye next. The laser was shone through the homeopathic solution in the vial to encode the frequencies of the remedy into the laser⁴. With her eyes closed, the laser was beamed around Andie’s eye brow, bridge of her nose, and upper cheek. Special care was taken to avoid shining the laser directly into her eye.

Result > After twenty minutes, her discomfort level decreased from 4 to 3 of 10

Given the success of thread moxabustion in treating localized Bartonella symptoms in other patients⁵, Andie was treated next with moxabustion around her eye.

Tx #4: Thread moxabustion
A common plant called artemisia argyii, also known as mugwort or moxa or by the Chinese name: Ai Ye, was used in Andie’s next treatment. A rare form of this plant uses only the underside hairs of the leaves, which is called ultra pure moxa. Four ounces of ultra pure moxa can cost several hundred US dollars. The ultra pure moxa was rolled into tiny threads and placed on Andie’s upper cheek, bridge of the nose, and on the eyebrow. Each thread was lit with an incense stick. As each thread grew hot, it was removed. After treating the area around her eye, Andie was astonished.

Result > After fifteen minutes, her discomfort level decreased from 3 to 0 of 10!

Fortunately, multiple treatments can reduce the pain and discomfort of stubborn Bartonella symptoms.

Using multiple anti-Bartonella treatments can quickly reduce the pain and inflammation associated with this infection
Just like shooting an arrow into the bull’s-eye of the target, using multiple anti-Bartonella treatments of Frequency Specific Microcurrent, acupuncture, laser delivered homeopathics, and ultra-pure moxabustion can target specific areas and relieve the pain, inflammation, and hot discomfort of a Bartonella infection. Since these treatments require specialized training to be used safely, please consult a Lyme literate Chinese medicine practitioner to see if these are a good fit for eliminating your Bartonella symptoms.

– Greg

P.S. Do you have experiences where treatment or remedies helped you eliminate or reduce Bartonella symptoms of eye pain, inflammation, or burning? Tell us about it.

>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday November 4th at 6pm to learn more about treatments and remedies for Bartonella infections, natural methods for reducing neurological problems, inflammation, and pain caused by Lyme disease. https://goodbyelyme.com/events/get_rid_lyme

1. Kalogeropoulos C, Koumpoulis I, Mentis A, Pappa C, Zafeiropoulos P, Aspiotis M. Bartonella and intraocular inflammation: a series of cases and review of literature. Clin Ophthalmol. 2011; 5: 817–829. Published online 2011 June 16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130920/
2. Corson, A. The Diagnosis and Treatment of Tick-Borne Diseases. Lyme Disease in the Family Conference. Salisbury, MD July 9th, 2011. https://www.lymepa.org/LDAESMD_July_2011_Conference_Info___Registration.pdf
3. Frequency Specific Microcurrent Advanced Summary Protocols. https://www.frequencyspecific.com/faq.php#protocol
4. Klinghardt, D. A Deep Look Beyond Lyme. 2012 Physician’s Round Table. January 28th, 2012. Tampa, FL.
5. Lee, Greg. Beyond Wack-A-Mole Lyme Treatment: What Has Helped People to Heal Lyme MCIDs Concurrent with or Post Drug Therapy. Integrative Lyme Solutions: The Evidence Basis Conference, Dallas, Texas, June 22, 2013.

Image courtesy of Bcc cindy and Casito of Wikimedia Commons

For people with bloating, indigestion, or gut toxicity from Lyme and co-infections
by Greg Lee

Have you ever had a small flood in your basement? My washing machine leaked a lot of water from a burst hose. After reading about how people getting sick from moldy buildings, my worst fears were giving me nightmares after I found several square feet of mold growing out of sight under some shelves.

How is a hidden mold colony similar to recurring digestion problems?

Just like a spreading mold problem, inflammation in the gut can develop in people with Lyme disease
Similar to mold that grows slowly out of sight, digestion discomfort can evolve slowly over time until it creates significant symptoms. Bertie experienced bloating, gas, and indigestion when he ate carbohydrates, greasy or sweet foods. After most meals, his belly was swollen, tender to the touch, and felt excessively full. After feeling worse after eating, he decided to give up those foods that increased his Lyme disease symptoms. Not only food but also medications for Lyme disease made his symptoms worse.

His symptoms would worsen on his antibiotic protocol
Bertie’s gut problems were aggravated whenever he rotated antibiotics. The toxic die off from drug treatment dramatically increased the tenderness and swelling in his gut. Biotoxins from Lyme disease and other tick infections have also been shown to increase the production of inflammatory compounds called cytokines¹. Some days the swelling would spread down his legs. He felt that his immune system was over-producing inflammation in response to his infection. Unfortunately, over the counter medications did little to relieve his symptoms.

Over the counter medications weren’t much help either
Antacids like Zantac and Prevacid didn’t help him to feel better. Gas-X and Bean-o helped a little with the gas. Dietary changes helped reduce symptoms however they would flare up with trigger foods or randomly for unknown reasons.

What else can help to relieve gut problems from a Lyme infections?

Here are five strategies that can help with reducing gut inflammation and discomfort
A combination of supplements, herbs, and treatments can help to reduce infection, toxicity and inflammation in the gut from a Lyme infection.

Strategy #1: Increase HCL to fight off microbes in the gut
As people age, they produce less hydrochloric acid (HCL)². Supplementing with HCL helped Bartie to better digest his trigger foods and reduce bloating, gas and inflammation. With HCL, he noticed a significant decrease in his symptoms that normally flared up with these foods. Aloe vera gel also helped to relieve inflammation and soothe his gut. Herbs also helped him to reduce the tenderness and swelling.

Strategy #2: Take herbs for reducing gut inflammation and detoxification
The herbs cnidium fruit and sophora have been used for hundreds of years to help people with gut problems due to multiple chronic infections.

Cnidium fruit, Chinese name: She Chuang Zi³
The properties of this herb are acrid, bitter, and warm. This herb treats weeping, itchy skin lesions in the lower part of the body, eczema, fungal skin infections, trichomoniasis, genital itching, vaginal discharge, hemorrhoids, scabies, and ringworm. Cnidium also treats low back pain, impotence and infertility.

This herb is contraindicated in patients with deficiency and excess heat in the lower part of the body. Cnidium inhibits Trichomonas vaginalis and some dematophytes. At the time of publication, no cautions or contraindications with medications have been discovered.

Sophora root, Chinese name: Ku Shen Gen⁴
The properties of this herb are bitter and cold. This herb clears heat and reduces inflammation and discharge in the lower part of the body. Sophora is also used to treat diarrhea, dysentery, foul smelling leukorrhea, genital itching, bleeding hemorrhoids, jaundice, and bleeding disorders. This herb is also used to treat dematological disorders, including itching, seepage, abscesses, urticaria, genital sores, leprosy, dysuria, and burning and pain with urination.

In clinical and animal studies, Sophora has been helpful in reducing arrhythmia characterized by excessive adrenaline, 62% of patients with arrhythmia successfully treated in another study, the alkaloids of this herb dilate blood vessels and increase blood perfusion to the cardiac muscles, lowered blood pressure and protected the heart from ischemia in one rabbit study, injections of d-oxymatrine increased white blood cells in mice, insomnia patients treated with 20 ml of a syrup of this herb reported greatly improved sleep, and relieved asthma in as short as one hour by stimulating the beta receptors of the sympathetic nervous system which relaxed the bronchioli. Sophora inhibits Bacillus dysentery, E. coli, Bacillus proteus, B-hemolytic streptococcus, and Staphylococcus aureus, and trichomonas. This herb is contraindicated in patients with coldness in the stomach. At the time of publication, no cautions or contraindications with medications have been discovered. In addition to herbs, gentle hand-on manipulation of the abdomen reduced inflammation.

Strategy #3: Move the inflammation out of the cells through visceral manipulation
Developed by osteopathic physicians, visceral manipulation uses gentle hands on pressure in the abdomen and over organs to relieve swelling, tenderness, and pain. When Bartie received visceral manipulation on his abdomen, he felt a tremendous increase of heat where he was being touched. After several minutes, the heat subsided and the tenderness to the touch was greatly reduced. His stomach felt less inflamed and less bloated. Not only does manipulation help, so does microcurrent treatment.

Strategy #4: Use Frequency Specific Microcurrent to reduce toxicity and inflammation in the gut and intestines
Bartie received Frequency Specific Microcurrent treatment to help his stomach and intestines, along with frequencies for neutralizing toxins, killing spirochetes, and reducing inflammation⁵. The swelling in his abdomen reduced fairly rapidly during his Frequency Specific Microcurrent sessions. Adding probiotics also helped reduce inflammation and improved elimination.

Strategy #5: Increase the amount of healthy probiotics through retention enemas
Bartie’s least favorite and yet a highly effective form of treatment was to give himself retention enemas at home. Inspired by the success of increasing healthy probiotics and reducing inflammation in the colon using fecal transplants⁶, Bartie was instructed to take an over-the-counter saline enema and dump out half the contents. He would add into the enema bottle over fifteen strains of over-the-counter probiotics and waited till they dissolved before self-administering his enemas. He held the enema in his rectum as long as he could. Since antibiotic therapy tends to wipe out probiotics like acidophilus or lactobacillus, he also included probiotic strains of S. boulardi and pediococcus which survive much better during antimicrobial drug treatment. He would sometimes add freeze dried garlic and tinctures of anti-parasite meds like clove and teasel root. His stool moved much more easily after each enema and he reported significantly less abdominal discomfort and inflammation. Multiple approaches help clean out inflammation, toxicity, and infection that can produce gut symptoms.

Using multiple approaches, patients report a significant reduction of gut discomfort
Similar to cleaning up a basement mold colony, the proper combination of treatments and herbs can help you to relieve gut inflammation and discomfort. Since some of these treatments come with cautions on their use, work with a Lyme literate complementary practitioner to develop a safe and effective strategy for healing gut problems.
– Greg

P.S. Do you have experiences where treatment or remedies helped you reduce gut discomfort and inflammation? Tell us about it.

>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday September 9th at 6pm to learn more about treatments and remedies for digestion difficulties, troublesome infections, natural methods for reducing neurological problems, inflammation, and pain caused by Lyme disease, co-infections, and yeast. https://goodbyelyme.com/events/get_rid_lyme

1. Shoemaker, R. The Biotoxin Pathway. https://www.survivingmold.com/diagnosis/the-biotoxin-pathway
2. Payne, M. The Use of Bio-Photonic Modulation in Complex Conditions., Physician’s Round Table (PRT) in Tampa, Florida, January 26, 2012. https://lymebook.com/vogan-blog/?p=39
3. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., pp. 1055 – 1056. https://www.amazon.com/Chinese-Medical-Herbology-Pharmacology-John/dp/0974063509
4. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., pp. 150 – 152. https://www.amazon.com/Chinese-Medical-Herbology-Pharmacology-John/dp/0974063509
5. Frequency Specific Microcurrent Advanced Summary Protocols. https://www.frequencyspecific.com/faq.php#protocol
6. Kruis W. Specific probiotics or ‘fecal transplantation’. Dig Dis. 2012;30 Suppl 3:81-4. doi: 10.1159/000342611. Epub 2013 Jan 3. https://www.ncbi.nlm.nih.gov/pubmed/23295696

Image courtesy Chuck Marean and Coyau of wiki commons

For people that have chronic joint pain, headaches, and inflammation that are not improving with Lyme disease treatment
by Greg Lee

On foraging trips with the local mushroom society, my mom would cringe as inexperienced newcomers would pick poisonous mushrooms that looked similar to edible ones. Fortunately on every trip, there were several mushroom experts that could teach the group how to distinguish between poisonous look-a-likes and their edible cousins. The embarrassed newcomers were extremely grateful learn the difference and avoid a trip to the emergency room for mushroom poisoning.

How is mistaking a poisonous mushroom for an edible look-a-like similar to a misdiagnosed Lyme disease infection?

Just like picking a poisonous mushroom that looks edible, there are infections that can produce symptoms very similar to a Lyme disease infection
Claire suffered with chronic migraines, back pain, joint inflammation, disturbed sleep, and high blood pressure. Her tests for all sorts of autoimmune disorders, infections, heart disease came up negative. She was prescribed high blood pressure and anti-inflammatory medicines for her symptoms. She was suspected of having Lyme disease due to living in an endemic area and her chronic recurring symptoms. Her Lyme Western Blot tests all came back negative.

Various medications, supplements and treatments gave her some relief for her migraines and joint symptoms
Chiropractic adjustments, acupuncture, and anti-inflammatory supplements brought some relief, however symptoms would quickly return a few days later. After many months, her doctor gave her the diagnosis of fibromyalgia and a prescription for Cymbalta. This medication helped a little with the pain. For several years, Claire just lived with the side effects of the medication: nausea, fatigue, and sweats. Fortunately, she decided to get a new type of scan that checks for electrical frequencies of different infections.

Electro-dermal scanning technology can help to find the hidden causes of persistent symptoms
Claire received an electro-dermal scan that checked different systems of her body for illness, infections, and possible remedies. The scan identified an elevated frequency corresponding to a Streptococcus B hemolytic infection hiding in her sinus and in her intestines. According to the CDC website¹, “[One of] the most common problems caused by Group B strep in adults are: Bone and joint infections.” Neurological strep infections have been associated with Parkinson’s disease². Could Strep B be contributing to Claire’s joint problems also?

Here are four strategies for clearing a Streptococcus B infection that helped Claire feel better quickly
Given that the strep B infection could be systemic, Claire’s treatment and medicines were focused on clearing out her infection from her sinuses, intestines, and joints. Strep can move through the blood, so anti-strep treatments for clearing infection from her entire body were also used. Given her concerns about drug resistant infections, she decided to try a natural approach first before taking more antibiotics. A combination of treatment and anti-strep natural medicines brought relief quickly.

Strategy #1: Use sublingual essential oils to target sinus infections
Claire received a mixture of essential oils that have inhibited strep B and strep species in lab studies: cinnamon, lemongrass³, clove⁴, eucalyptus, and tea tree⁵. Every night, she held a few drops under her tongue to allow the oils to diffuse into her sinus cavities. Within a few days her headaches subsided. Claire also drank herbs processed into a liposomal mixture to target infections in her body.

Strategy #2: Take liposomal herbs to focus on system infections
Liposomal herbs are processed into a very small particle size and have a lecithin (lipid) covering which increases absorption. Claire took a customized liposomal mixture of herbs that inhibit or have anti-strep properties in different experiments: forsythia fruit⁶, artemisia argyii⁷, angelica root⁸, asparagus root⁹, buplerum¹⁰, scutellaria¹¹, coptidis¹², sophora¹³, tree peony¹⁴, honeysuckle flower¹⁵, and curcuma zedoraria¹⁶. Liposomal herbal formulas have been highly effective at relieving joint symptoms compared to herbs in alcohol tinctures, decoctions, or powdered herbs for patients infected with Lyme disease¹⁷. Frequency Specific Microcurrent treatments also help to target localized and systemic strep infections.

Strategy #3: Apply Frequency Specific Microcurrent to kill strep locally and systemically
Frequency Specific Microcurrent treatments uses a pair of low level electrical currents, labelled A and B, in the millionths of an amp range. The “A” current pair was used for killing strep B or eliminating strep toxins. The “B” current pair was used to target the entire body, sinuses, small intestine, large intestine, low back, and lower extremity joints¹⁸. Claire felt much more relaxed and energized after receiving microcurrent frequencies for killing and detoxing strep systemically and locally. Changing her diet also helped.

Strategy #4: Eat foods that help kill strep
There are foods that have inhibit strep in lab experiments. Claire added asparagus¹⁹, scallion²⁰, and drank chrysanthemum flower²¹ tea to her diet to fight strep. She felt a difference in her symptoms soon after getting treatments, taking her medicines, and changing her diet.

Claire felt a big difference in a few days
Three days after her first treatment, she felt a huge decrease in her joint pain.  She was excited to feel how treatment, the essential oils and herbs were working. The diet seemed to help also. A few weeks into her treatment, she increased her dose of essential oils and then felt worse from killing off too many germs too quickly. After backing her dose down of herbs and oils, she found that she was less symptomatic and more functional. A combination of four strategies can help you fight a systemic strep infection.

These four strategies can help to fight off a systemic strep infection
Just like being able to identify edible mushrooms versus poisonous ones, electro-dermal testing helps to identify which infections may be the biggest troublemakers. Antimicrobial strategies can then be selected to target the most troublesome infections. In Claire’s example, sub-lingual and oral essential oils, herbs, Frequency Specific Microcurrent, and dietary changes helped her to reduce the symptoms caused by a systemic strep infection. Since some of these herbs and essential oils have cautions on their use, work with an herbalist knowledgeable in antimicrobial medicines to develop a proper, safe, and effective strategy for your condition.

– Greg

P.S. Do you have experiences where electrodermal scanning helped you identify underlying infections? Which herbs, essential oils, or treatments helped you to reduce recurring migraines, inflammation, or joint pains? Tell us about it.

>> Next step: Come to our evening lecture:  Getting Rid of Lyme Disease in Frederick, Maryland on Monday August 5th at 6pm to learn more about electrodermal scanning for hidden troublesome infections, natural methods for reducing neurological problems, inflammation, and pain caused by Lyme disease, co-infections, and yeast.  https://goodbyelyme.com/events/get_rid_lyme

1.        Group B Strep Infection in Adults. https://www.cdc.gov/groupbstrep/about/adults.html
2.        Gordon, Gary. LYME Could Be Called L. I. M. E. S. (Lowered Immune Metabolic Encephalo-arthropathy Syndrome). Integrative Lyme Solutions: The Evidence Basis Conference. Dallas, Texas. June 21, 2013.
3.        Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PA, Wiltfang J, Fickenscher H, Sherry E. The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Craniomaxillofac Surg. 2009 Oct;37(7):392-7. doi: 10.1016/j.jcms.2009.03.017. https://www.ncbi.nlm.nih.gov/pubmed/19473851
4.        Fabio A, Cermelli C, Fabio G, Nicoletti P, Quaglio P. Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. Phytother Res. 2007 Apr;21(4):374-7. https://www.ncbi.nlm.nih.gov/pubmed/17326042
5.        Takarada K, Kimizuka R, Takahashi N, Honma K, Okuda K, Kato T. A comparison of the antibacterial efficacies of essential oils against oral pathogens. Oral Microbiol Immunol. 2004 Feb;19(1):61-4. https://www.ncbi.nlm.nih.gov/pubmed/14678476
6.        Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 175.
7.        Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 601.
8.        Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 921.
9.        Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 947.
10.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 85.
11.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 139.
12.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 143.
13.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 152.
14.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 161.
15.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 172.
16.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 667.
17.      Lee, Greg. Beyond Wack-A-Mole Lyme Treatment: What Has Helped People to Heal Lyme MCIDs Concurrent with or Post Drug Therapy. Integrative Lyme Solutions: The Evidence Basis Conference, Dallas, Texas, June 22, 2013.
18.      Frequency Specific Microcurrent Advanced Summary Protocols. https://www.frequencyspecific.com/faq.php#protocol
19.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 947.
20.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 59.
21.      Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 76.

Image courtesy of Paffka from Wikimedia Commons

For people that have difficulty sleeping due to Lyme disease and co-infections
by Greg Lee

When I was growing up, we had an old tea kettle that we used for making hot water. When the water boiled, the whistle on the spout would make a really shrill noise you could hear throughout the house. Each time it whistled, our collection of over a dozen guinea pigs would squeak loudly with the teapot. The noise was so loud, it was impossible to hear oneself think.

How is a loud whistling tea pot similar to insomnia from Lyme disease?

Similar to a boiling teapot, people with Lyme disease can have too much mental noise or agitation which prevents them from sleeping
Just like a whistling tea kettle, Janey’s mind at night would bounce from one loud thought to the next about dealing with her Lyme disease and co-infections. Sometimes aches, pains, or buzzing in her legs would get in the way of finding a comfortable sleeping position. At some late hour, she would eventually doze off and get a few hours of restless sleep. The next morning, she’d wake up and feel like she had never slept. She tried lots of medication and supplements to get her mind and body to doze off.

Supplements and medications can help with insomnia from Lyme disease
Janey found that stopping all caffeine and taking melatonin helped a little. She found that Ambien and Lunesta also helped, however she wanted a more restful quality than drugged sleep. Whenever, she got a good night of sleep, she felt a huge difference in her energy levels, mental clarity, and emotional outlook the next day. However, her insomnia got worse whenever she switched to a new antibiotic. She began to dread getting a new prescription and the sleeplessness that followed. Her blood tests showed elevated inflammatory markers.

Increased inflammation can be measured in people with insomnia
In Intensive Care Unit (ICU) studies of patients, sleep deprivation increased immune system dysfunction, impaired wound healing, and changes in behavior¹. In one mouse study, sleep deprived mice had elevated levels inflammatory cytokines:  Interleukin-6 (IL-6), Tumor Necrosis Factor (TNF-α), and Interferon-gamma (IFN-γ)². In one human sleep study, patients with insomnia showed increased metabolism in multiple areas of the brain and elevated levels of cortisol and IL-6³. In another study on sleep deprived caregivers, elevated levels of a protein fragment called D-Dimer, which indicates increased hypercoagulation⁴. Unfortunately, Janey’s blood tests showed elevated levels of IL-6, TNF-α, and TGF-β. There appears to be a clinical correlation between elevated toxins that can increase both hypercoagulation and insomnia.

Increased toxins can also aggravate insomnia
According to the Biotoxin Pathway, elevated biotoxins from Lyme disease and Babesia can produce symptoms that can increase insomnia: body discomfort, mental unease, and emotional agitation⁵. This pathway also describes how drug resistant staph germs that reside in nasal passages, called Multiple Antibiotic Resistant Coagulase Negative Staph (MARCoNS), produce toxins that get into the brain and can disrupt sleep⁶. These toxins can desynchronize or disrupt the electrical flow between the right and left hemispheres of the brain which also increases discomfort and insomnia⁷.

What strategies can help to clear toxins, reduce inflammation, and deepen sleep?

Combining multiple treatments can enhance and deepen sleep
When Lyme disease patients get improved sleep, they report increased vitality, mental clarity, and a more hopeful outlook. Here are several treatments and natural medicines which have helped many patients to eliminate infections and their toxins that disturb sleep and rest more deeply.

Strategy #1: Use sublingual essential oils for cutting through nasal biofilms and MARCoNS.
Janey was diagnosed with MARCoNS by her Lyme literate doctor. Her nasal medications helped to improve her frequent post-nasal drip, sinus congestion, and restless sleep. Her sleep dramatically improved soon after taking a customized combination of essential oils under her tongue before bed each night. She also adds these oils to a coconut oil mouth wash, called oil pulling, that she does every morning. Several of her essential oils have been shown to inhibit Staphylococcus and/or their biofilms in lab experiments, including: bay⁸, frankincense⁹, orange¹⁰, and peppermint¹¹. Thyme and oregano essential oil reduced IL-1β, IL-6, GM-CSF, and TNF-α in one mouse study¹². An herb like frankincense can also help with promoting sleep.

Strategy #2: Burn frankincense resin to help clear staph out of the sinuses
In ancient Mesopotamia, frankincense has been used to clean wounds of infections¹³. In animal experiments, a compound called incensole acetate in frankincense has demonstrated anti-depressant properties¹⁴, and inhibits TNF-α, IL-1β and TGF-β expression¹⁵. In lab experiments, frankincense essential oil inhibits formation of Staph and Candida biofilms¹⁶. Janey placed pieces of frankincense resin on hot charcoal to release the active compounds and inhaled a little of the smoke. Inhaling the smoke enables the compounds to travel into her sinuses to reach nasal Staph and biofilms. As a result of inhaling frankincense smoke, she reported greater mental peace and more restful sleep. Electro acupuncture can also help to reduce the electrical imbalances that disturb sleep.

Strategy #3: Use electro-acupuncture to improve the quality of sleep
In one study on breast cancer patients with hot flushes, electro acupuncture improved their quality of sleep¹⁷. Janey reported staying asleep longer in the days after receiving electro acupuncture for thirty minutes. Needles were placed on the right and left sides of the head in the back of her neck in acupuncture points along her Gall Bladder pathway (GB-30 and GB-17) using a dispersion wave setting on a KWD-808I electro acupuncture device with the intention of helping her right and left hemispheres of her brain to re-synchronize. In addition to electro acupuncture, low level microcurrent can help reduce inflammation and toxicity that can prevent deep sleep.

Strategy #4: Reduce Central Nervous System inflammation and toxicity with Frequency Specific Microcurrent
Frequency Specific Microcurrent (FSM) uses a pair of very low electrical currents to work on a specific area and to promote healing¹⁸. In order to improve her quality of sleep, Janey was given multiple FSM treatments to reduce toxicity, inflammation, and protozoa infection in different areas of the brain: hippocampus, hypothalamus, brain stem, and thalamus. Not only does microcurrent help patients to sleep better, so does pulsed light therapy.

Strategy #5: Assist the brain to enter into a deeper sleep state using pulsed light therapy
In a traumatic brain injury study, an 810 nm laser pulsed at 10Hz helped with brain recovery and reducing depression better than other pulse rates¹⁷. Using an 810 nm pulsed LED light at 10 Hz in her nose, Janey immediately felt her brain relax. After a few minutes, she felt increased mental clarity and energy. Using the intranasal LED at night just before bed, helped her to experience a deeper state of rest. The intention of using a 10 Hz pulse rate is to help the brain to enter into an alpha wave sleep state which is 8 – 12 Hz. Multiple methods can deepen sleep by inducing an alpha state and eliminating the infections, excess toxins, inflammation that can drive insomnia.

Multiple methods and treatments can help reduce insomnia due to toxins and inflammation
Just like turning off the heat under a whistling teapot, using a combination of herbs, essential oils, electro acupuncture, Frequency Specific Microcurrent, and pulsed light therapy can help to reduce the mental noise and physical agitation that keep patients awake at night. These methods work together to reduce infections, toxins, and inflammation that can disturb sleep. Since some of these herbs and treatments are contraindicated with certain conditions, work with a Lyme literate acupuncturist and herbalist to develop a proper, safe, and effective strategy for your situation.

P.S. Do you have experiences where herbs or treatment helped you to reduce Lyme disease insomnia? Tell us about it.

>> Next step: Click here to learn more about natural treatments for Lyme, C. diff and co-infections in our private HEAL for REAL Facebook Group!

1. Patel M, Chipman J, Carlin BW, Shade D. Sleep in the intensive care unit setting. Crit Care Nurs Q. 2008 Oct-Dec;31(4):309-18; quiz 319-20. doi: 10.1097/01.CNQ.0000336816.89300.41. https://www.ncbi.nlm.nih.gov/pubmed/18815477
2. Kim JY, Lee YD, Kim BJ, Kim SP, Kim DH, Jo KJ, Lee SK, Lee KH, Baik HW. Melatonin improves inflammatory cytokine profiles in lung inflammation associated with sleep deprivation. Mol Med Rep. 2012 May;5(5):1281-4. doi: 10.3892/mmr.2012.814. https://www.ncbi.nlm.nih.gov/pubmed/22377793
3. Riemann D, Kloepfer C, Berger M. Functional and structural brain alterations in insomnia: implications for pathophysiology. Eur J Neurosci. 2009 May;29(9):1754-60. doi: 10.1111/j.1460-9568.2009.06721.x. https://www.ncbi.nlm.nih.gov/pubmed/19473230
4. Wilde JT, Kitchen S, Kinsey S, Greaves M, Preston FE. Plasma D-dimer levels and their relationship to serum fibrinogen/fibrin degradation products in hypercoagulable states. Br J Haematol. 1989 Jan;71(1):65-70. https://www.ncbi.nlm.nih.gov/pubmed/2917130
5. Shoemaker, R. The Biotoxin Pathway. https://www.survivingmold.com/diagnosis/the-biotoxin-pathway
6. Klinghardt, D. A Deep Look Beyond Lyme. 2012 Physician’s Round Table. January 28th, 2012. Tampa, FL.
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8. Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol. 1999 Jun;86(6):985-90. https://www.ncbi.nlm.nih.gov/pubmed/10438227
9. Schillaci D, Arizza V, Dayton T, Camarda L, Di Stefano V. In vitro anti-biofilm activity of Boswellia spp. oleogum resin essential oils. Lett Appl Microbiol. 2008 Nov;47(5):433-8. doi: 10.1111/j.1472-765X.2008.02469.x. https://www.ncbi.nlm.nih.gov/pubmed/19146534
10. Muthaiyan A, Biswas D, Crandall PG, Wilkinson BJ, Ricke SC. Application of orange essential oil as an antistaphylococcal agent in a dressing model. BMC Complement Altern Med. 2012 Aug 16;12:125. doi: 10.1186/1472-6882-12-125. https://www.ncbi.nlm.nih.gov/pubmed/22894560
11. Anghel I, Grumezescu AM. Hybrid nanostructured coating for increased resistance of prosthetic devices to staphylococcal colonization. Nanoscale Res Lett. 2013 Jan 2;8(1):6. doi: 10.1186/1556-276X-8-6. https://www.ncbi.nlm.nih.gov/pubmed/23281840
12. Bukovská A, Cikos S, Juhás S, Il’ková G, Rehák P, Koppel J. Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice. Mediators Inflamm. 2007;2007:23296. doi: 10.1155/2007/23296. https://www.ncbi.nlm.nih.gov/pubmed/18288268
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14. Moussaieff A, Gross M, Nesher E, Tikhonov T, Yadid G, Pinhasov A. Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals. J Psychopharmacol. 2012 Dec;26(12):1584-93. doi: 10.1177/0269881112458729. Epub 2012 Sep 26. https://www.ncbi.nlm.nih.gov/pubmed/23015543
15. Moussaieff A, Yu J, Zhu H, Gattoni-Celli S, Shohami E, Kindy MS. Protective effects of incensole acetate on cerebral ischemic injury. Brain Res. 2012 Mar 14;1443:89-97. doi: 10.1016/j.brainres.2012.01.001. Epub 2012 Jan 9. https://www.ncbi.nlm.nih.gov/pubmed/22284622
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For people that have inflammation, brain fog, or a lack of vitality due to Lyme disease and co-infections
by Greg Lee

Several years ago, one of my NASA colleagues had a memory lapse that almost ended in disaster. After moving into a new house, he hooked up a hose to fill up his waterbed. He soon got distracted with unpacking boxes and talking with other people. Over an hour later, he went back into his bedroom and his water bed had swelled up like a balloon to three times its normal size.

How is an overfilled waterbed similar to inflammation caused by Lyme disease and other chronic infections?

Similar to a ballooning waterbed, Lyme disease patients can have excessive inflammation
The immune system produces compounds called pro-inflammatory cytokines that can increase swelling in response to an infection. In the initial stages of an infection, this is a healthy response to an invading germ. In patients with chronic Lyme disease and/or co-infections, the immune system can over produce pro-inflammatory cytokines which can lead to persistent symptoms of swelling, pain, or mental fog.

Lyme disease and co-infections can trigger elevated levels of inflammatory cytokines
Excess interferon gamma (INF-γ), a pro-inflammatory cytokine, has been found in early Lyme disease patients with an erythema migrans (EM) rash. In patients with systemic symptoms, interleukin-1 beta (IL-1β) and tumor necrosis factor – alpha (TNF-α) were more frequent¹. In mice infected with Babesia WA-1 showed elevated levels of TNF-α and INF-γ². In animal studies on Bartonella henselae, these cytokines were elevated: INF-γ and interleukin – 4 (IL-4)³, TNF-α⁴, IL-1β, and interleukin – 6 (IL-6)⁵ in chronic and high levels of infections. Not only tick infections can increase inflammatory cytokines, so can secondary infections.

Secondary infections like staph and yeast can also elevate inflammatory compounds
Lyme disease patients that undergo lengthy antibiotic therapy are at a higher risk of developing secondary infections from yeast like Candida species, staph, and Clostridium difficile, In animal studies, Candida albicans has been shown to increase interleukin-1 alpha (IL-1α), IL-1β, interleukin-8 (IL-8), granulocyte-macrophage colony-stimulating factor (GM-CSF), TNF-α⁶, and inducible cyclooxygenase (cox2)⁷. Staphlococcus aureus in rodent studies induces TNF-α, IL-1β, INF- γ⁸, and IL-1α⁹. Clostridium difficile in animal studies has been shown to elevate IL-6, IFN-γ, IL-1β, interleukin-10 (IL-10), and interleukin-12 (IL-12)¹⁰. When cytokines are chronically elevated, they can produce stubborn symptoms of pain, swelling, and arthritis.

Elevated cytokines can lead to unhealthy side effects like joint pain and swelling
According to Dr. Ritchie Shoemaker’s Biotoxin Pathway, toxins from Lyme disease, babesia, mold and toxic algae can lead to elevated cytokine levels which can produce symptoms of inflammation. Inflammatory symptoms can include: flu-like symptoms, headaches, muscle aches, fatigue, unstable temperature, concentration difficulties, and increased clot and arterial blockage¹¹. Lyme patients with chronic inflammation report additional symptoms of arthritis, bloating, distention, digestion difficulties, a lack of vitality, memory recall problems, a racing heart, and insomnia.

How can knowing about “dampness” from Chinese medicine help patients to reduce their persistent symptoms of inflammation?

In Chinese medicine, dampness is a keyword for inflammation
Dampness in Chinese medicine can indicate swelling, inflammation, and the effects of an infection. Dampness can interfere with healthy functioning of the tissues, organs, emotions, and also the clarity of the mind. When describing symptoms of the body, mind, or emotions, this is referred to as internal dampness. Damp weather, like humidity or rain, and environments with lots of moisture, like swamps, are classified as external damp conditions. When a person is exposed to external damp conditions, their symptoms of inflammation can increase. Similarly, “damp” foods can also increase swelling and joint discomfort. Reducing consumption of damp foods can also decrease symptoms of inflammation.

Method #1: Stop eating “damp” foods that produce inflammation
Reducing your consumption of sweet or high fat foods like dairy, wheat, and sugar, helps to reduce internal dampness. By increasing the intake of bitter or tart foods and spices that are classified as “drain dampness” foods, you can help reduce inflammation. Daily consumption of tart cherry juice reduced TNF-α¹² and IL-1β¹³. In one rat study, tart cherry powder reduced IL-6, cholesterol, and belly fat¹⁴. In another rat study, wild blueberry reduced the transcriptional nuclear factor-KappaB (NF-kB), C-reactive protein (CRP), IL-6 and TNF-α¹⁵. Not only foods help to reduce inflammation, but also herbs.

Method #2: Increase herbs that reduce symptoms of inflammation
Just like foods, there are herbs that help to reduce inflammatory cytokines. Turmeric, Chinese name: jiang huang, activates circulation and eliminates blood stagnation. It is used to relieve pain and reduce swelling. Turmeric is to be used with caution in weak patients that do not have signs of stagnation and is contraindicated during pregnancy¹⁶. Turmeric has been shown to decrease IL-1, IL-8, and TNF¹⁷. Curcumin, a compound found in turmeric, has inhibitory effects on cyclooxygenases 1, 2 (COX-1, COX-2), lipoxygenase (LOX), TNF-α, IFN-γ, inducible nitric oxide synthase (iNOS), and NF-kB¹⁸.

Polygala tenuifolia, Chinese name: yuan zhi, expels phlegm (dampness) that causes mental and emotional disorientation, seizures, hearing loss, and lung congestion. This herb reduces abscesses, dissipates swellings, pacifies the heart and calms the spirit. Polygala is used with caution in patients with heat symptoms or dryness. It is also cautioned in patients with gastritis, stomach ulcers, and during pregnancy¹⁹. Polygala has an inhibitory effect on IL-1, TNF, and IFN-γ²⁰. Highly concentrated essential oils that are extracted from herbs can also help to reduce cytokines.

Method #3: Use essential oils that decrease inflammatory cytokines
Tea tree essential oil reduces TNF-α, IL-1β, IL-10 and PGE2²¹ in one lab experiment. Tea tree essential oil also has anti-microbial properties against fungal²², staph and E. coli²³ biofilms. Bergamot orange essential oil blocks INF-γ in one lab study²⁴. Apigenin, a flavonoid in German chamomile essential oil, inhibits IL-1a, TNF-α induced IL-6 and IL-8 production²⁵. These essential oils have been used safely internally and topically for years in patients diagnosed with chronic Lyme disease. Not only food and botanical medicines can reduce cytokines, so can cupping with acupuncture.

Method #4: Get cupping and acupuncture to reduce inflammation
Another method for reducing cytokines in Lyme disease patients, wet cupping uses needles and suction cups to draw lymph fluid, blood, and toxins²⁶ from the body. In one study, cupping and acupuncture reduced IL-6 levels²⁷.

Patients report significant relief in their symptoms of inflammation, pain, depression, lack of vitality, and mental fog immediately after cupping. Cupping is cautioned in patients with weakness or anemia, and contraindicated in patients with bleeding disorders. A combined approach can help reduce inflammation from Lyme disease.

Multiple methods and treatments can help reduce inflammation due to abnormal cytokine production
Before his water bed could burst, my colleague quickly shut off the faucet and let the excess water drain out the window. Decreasing inflammation can be enhanced through dietary modifications and herbs that “drain dampness”, and essential oils and treatments that reduce excess pro-inflammatory cytokines. Since some of these herbs and treatments are contraindicated with certain conditions, work with a Lyme literate acupuncturist and herbalist to develop a proper, safe, and effective strategy for your situation.

P.S. Do you have experiences where herbs or treatment helped you to reduce Lyme disease inflammation? Tell us about it.

>> Next step: Come to our evening lecture:  Getting Rid of Lyme Disease in Frederick, Maryland on Monday May 6th at 6pm to learn more about natural methods for swelling, inflammation, and pain caused by Lyme disease, co-infections, and yeast.  https://goodbyelyme.com/events/get_rid_lyme

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11. Shoemaker, R. The Biotoxin Pathway. https://www.survivingmold.com/diagnosis/the-biotoxin-pathway
12. Martin, K.R., Burrell L. (2010) 100% tart cherry juice reduces pro-inflammatory biomarkers in overweight and obese subjects. FASEB Journal. 24 pp. 724.15 https://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/724.15
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For people that are abnormally cold due to their Lyme, Bartonella, or Babesia infections
by Greg Lee

When I was a teenager, I went on a month long Outward Bound training course with several other people. We would hike by day and at night we’d build a fire and cook dinner. One evening, our adventure was interrupted by an ominous gust of wind and then a rainstorm. Our efforts to keep the fire going worked at first. However, the rain kept coming and eventually put the campfire out. As I watched the last wisps of smoke from the fire, I imagined shivering that night to stay warm inside a damp tent.

How is a campfire that is drowned in a rainstorm similar to chronic tick infections that attack your immune system?

Just like rain on a sputtering campfire, multiple tick infections can dampen your immune system
Gerald noticed that he began to feel much colder in winter. It would take 30 minutes in a hot sauna for him to feel warm again. After the sauna, he felt as if he had sweated out of a bunch of toxins. Unfortunately, his chronic fatigue, feeling toxic, and brain fog would soon return along with being deeply cold again. He discovered that his house had a thriving mold colony caused by water damage in the basement. He was also diagnosed by his Lyme Literate Doctor with Lyme disease, Babesia, and Bartonella co-infections.

Toxins from Lyme disease and co-infections zap your ability to heat up and kill infections
The hypothalamus has organs that sample the blood stream and regulate changes in body temperature. When it detects the presence of infections, the hypothalamus induces a fever to heat up and kill off infectious germs. Unfortunately, toxins released by Lyme, mold, and co-infections can get absorbed by the hypothalamus and block its ability to induce germ killing fevers¹. When antibiotics, herbal medicines, and treatments kill off these infections, more toxins can be released and produce a Herxheimer reaction. These toxins can persist in some people lacking specific genes.

Toxins can be hard to eliminate in people who are missing anti-toxin HLA genes
Gerald is missing several Human Leukocyte Antigen (HLA) genes for eliminating toxins. After extended periods of time in his moldy home, many of his symptoms got much worse: irregular heart rate, insomnia, fatigue, and mental confusion. He would also have spikes in symptoms every four weeks which correlated with the lifecycle of his Lyme disease infection.

Cleaning the mold out helped Gerald feel better immediately
After an Environmental Relative Moldiness Index (ERMI) test showed high levels of toxic mold, Gerald and his wife hired a remediation company to clean out their entire house. Most walls and ceilings were stripped down to the stud timbers. The entire heating and cooling system was either cleaned or replaced. Leaks in the foundation were sealed. After venturing back into his newly renovated home, Gerald did not have an immediate flare up of his symptoms. However, he still had a very low body temperature and recurring symptoms of insomnia, brain fog, and fatigue.

What else can help Gerald to boost his immune system in fighting his multiple toxic infections?

Warming herbs help boost the immune response against tick borne infections
Warming herbs, also called Yang strengthening herbs in Chinese medicine, help to raise your body temperature which can help kill off infections. For every 0.2 degrees Celsius that body temperature is increased, approximately 50% of your infections are killed off². There are three herbs that have been effective at heating up people with low body temperatures caused by their Lyme disease and tick borne infections.

Warming herb #1: Fructus Evodia, Euodia, or Bee Bee Tree Fruit, Chinese name: Wu Zhu Yu³
The properties of this warming herb are bitter, acrid, and hot. This herb is used to dispel cold, dry dampness, activate Qi energy circulation, and relieve pain. Dampness in Chinese medicine can be translated to mean infection and their effects. Evodia treats pain characterized by a cold, fixed, and stabbing nature. It has been used to treat epigastric and abdominal pain, hernial pain, dysmenorrhea, nausea, vomiting, diarrhea with undigested food, cold extremities, spasms, and headache at the top of the head. The classical Chinese character for this herb shows two hands lifting up on either side of a head.

Evodia has also been used to treat migraine headaches, acid reflux, “cocks crow” or early morning diarrhea, chronic dysentery, hypertension, mouth and tongue ulcers, eczema, and sores on the scalp. This herb is contraindicated in patients with excess heat and dryness. Short-term use and small doses are recommended due to its low level of toxicity.

In animal studies, Evodia prevents and treats stomach ulcers by reducing gastric acid secretions. In mice studies, this herb has antidiarrheal properties. It has a marked effect in decreasing blood pressure in several animal studies. In a rat study, it had a slight effect but not significant effect on raising body temperature⁴. This herb inhibits Pseudomonas aeruginosa, Staphylococcus aureus, and some dermatophytes. It also inhibits the growth of the helicobacter pylori bacteria⁵.

Recent studies have focused on the anticancer properties of an alkaloid compound called evodiamine found in evodia. This compound has inhibited proliferation, invasion, and metastasis in the following cancer cells: breast, prostate, leukemia, melanoma, cervical, colon, and lung⁶.

Warming herb #2: Galanga or Alpinia, Chinese name: Gao Liang Jiang⁷
The properties of this warming herb are acrid and hot. It is used to dispel coldness from the middle of the body especially the spleen and stomach. This herb has been used to treat epigastric and abdominal pain, nausea, vomiting, food stagnation, intestinal cramps, and diarrhea. Galanga has also been used to treat sharp, stabbing pain in the chest or abdomen, intestinal cramps, acute and chronic diarrhea.

This herb has demonstrated analgesic effects on the gastrointestinal system. It has been effective at preventing and treating peptic ulcers and diarrhea. Water extracts of this herb have been shown to decrease intestinal peristalsis. Galanga has been effective at treating angina. It has an inhibitory effect on Bacillus anthracis, Corynebacterium diptheriae, Diplococcus pneumoniae, Salmonella typhi, Staphylococcus aureus, B-hemolytic streptococcus, and Mycobacterium tuberculosis hominis. This herb also has a weak antimalarial effect in mice and is used topically for treating eczema and ringworm⁸. Due to its warming nature, this herb is contraindicated in patients with excess heat and dryness.

Galanga essential oil has many bioactive compounds including: Limonene, gamma-Terpinene, alpha-Terpinolene, 1-Undecene, Borneol, para-Cymen-8-ol, alpha-Terpineol, and Z-Citral. This essential oil was more effective at killing E. coli, Staphylococcus aureus, Shigella sonnei, Salmonella typhi than gentomycin⁹.

Warming herb #3: Turmeric, Chinese name: Jiang Huang¹⁰
The properties of this spice herb are acrid, bitter, and warm. It is used to activate blood circulation and eliminate blood coagulation. This herb is used to treat stabbing, fixed pain caused by blood stagnation or hypercoagulation. Turmeric is also used to treat hypochondriac pain due to liver stagnation, abdominal pain due to blood stagnation, chest pain, epigastric pain, dysmenorrhea, and hepatitis with hypochrondriac pain.

It is also used to treat “painful obstruction syndrome” especially in the upper limbs. This herb reduces swelling from sores and lesions caused by toxic heat along with blood hypercoagulation. Turmeric is contraindicated during pregnancy.  This herb is also contraindicated in weak patients that do not have blood stagnation.

The main constituent of turmeric is the compound curcumin. Curcumin is being researched for its properties for fighting cancer, killing viruses, reducing inflammation, treating Alzheimer’s disease and Parkinson’s Disease because of its anti-amyloid activities¹¹. In lab experiments, curcumin is highly effective at killing the malarial parasite¹². Another anti-malarial study demonstrated the efficacy of combining curcumin and artemisinin in mice¹³. Adding a black pepper extract called piperine significantly increases the uptake of curcumin¹⁴. Boiling curcumin for ten minutes increased its bioavailability twelve-fold in another study¹⁵.

What happens when these warming herbs are used by people with multiple infections?

Warming herbs helped Gerald to finally warm up his popsicle toes
Gerald’s average morning temperature hovered around 95 degrees Fahrenheit. After taking daily a mixture of liposomal herbs, his temperature began to slowly rise. For the first several weeks, he felt more fatigue and brain fog due to the die off of his infections. After four weeks of taking a daily mixture of anti-infection and warming herbs, his average morning temperature hovered around 97 degrees. His wife complained less about his cold feet. Then his symptoms shifted.

For the first time in many months, Gerald felt like a new person
He reported having a greater amount of energy and increased clarity in his thinking. Work tasks that required mental mental concentration and focus, became easier and easier for Gerald. He found that he had enough energy to restart exercising again. By increasing his dose of warming herbs, Gerald’s morning temperature was raised to around 98 degrees Fahrenheit. Also, his recurring symptoms were less frequent and less severe. Warming herbs can help the immune system to heat up and fight off multiple infections.

Warming herbs can help the immune system to cook off infections
My outdoor adventure had a happy ending. After the rain passed, we were able to find dry kindling, restart the fire and dry off. Similarly, warming herbs can help restart the immune system’s ability to heat up the body and kill off multiple infections. Since some of these herbs are contraindicated in people with excess heat or dryness, work with a Lyme literate herbalist knowledgeable in warming herbs to develop a proper, safe, and effective strategy for your condition.

Do you have an experience with heating up from the chill of Lyme disease or co-infections? Tell us about it.

>> Next step: Come to our evening lecture:  Getting Rid of Lyme Disease in Frederick, Maryland on Monday February 4th at 6pm to learn more about natural methods for warming up and killing infections, relieving pain, insomnia, fatigue, and brain fog caused by Lyme disease, mold toxins, and co-infections.  https://goodbyelyme.com/events/get_rid_lyme

1. Klinghardt, D. A Deep Look Beyond Lyme. 2012 Physician’s Round Table. January 28th, 2012. Tampa, FL.
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3. Kano Y, Zong QN, Komatsu K. Pharmacological properties of galenical preparation. XIV. Body temperature retaining effect of the Chinese traditional medicine, “goshuyu-to” and component crude drugs. Chem Pharm Bull (Tokyo). 1991 Mar;39(3):690-2. https://www.ncbi.nlm.nih.gov/pubmed/2070449
4. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 452 – 454.
5. Evodia Fruit – Wu Zhu Yu. https://www.acupuncture.com/newsletters/m_july09/wuzhuyu.htm
6. Jiang J, Hu C. Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa. Molecules. 2009 May 18;14(5):1852-9. https://www.ncbi.nlm.nih.gov/pubmed/19471205
7. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 460 – 461.
8. Alpinia galanga. https://en.wikipedia.org/wiki/Alpinia_galanga
9. Prakatthagomol W, Klayraung S, Okonogi S. Bactericidal action of Alpinia galanga essential oil on food-borne bacteria. Drug Discov Ther. 2011 Apr;5(2):84-9. https://www.ncbi.nlm.nih.gov/pubmed/22466145
10. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 623 – 624.
11. S. Dharmananda. Neuroprotective Herbs and Active Constituents, Approaches to Preventing Degenerative Diseases. https://www.itmonline.org/arts/neuro.htm
12. L. Cui, J. Miao, and L. Cui. Cytotoxic Effect of Curcumin on Malaria Parasite Plasmodium falciparum: Inhibition of Histone Acetylation and Generation of Reactive Oxygen Species. Antimicrob Agents Chemother. 2007 February; 51(2): 488–494. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797756/
13. Nandakumar DN, Nagaraj VA, Vathsala PG, Rangarajan P, Padmanaban G. Curcumin-artemisinin combination therapy for malaria. Antimicrob Agents Chemother. 2006 May;50(5):1859-60. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472230/
14. Mimche PN, Taramelli D, Vivas L. The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria. Malar J. 2011 Mar 15;10 Suppl 1:S10. https://www.malariajournal.com/content/10/S1/S10
15. Kurien BT, Scofield RH. Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability. Clin Cancer Res. 2009 Jan 15;15(2):747; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693878/

For people that are fighting a stubborn toxic mold infection
by Greg Lee

My sister had over a dozen guinea pigs when I was growing up. They loudly squeaked every time a person walked by, hoping to get fed. They would consume massive amounts of greens, grasses, and vegetables. My chores somehow included cleaning out their pens. Cleaning often required a scraper and a hose to get the waste out of the hard to reach corners of their habitat.

How is cleaning out guinea pig pens similar to eliminating a toxic mold infection?

Just like encrusted guinea pig pens, toxic mold can accumulate in hard to reach corners of the body
Several species of toxic mold can grow in homes, schools, or offices including: Cladosporium, Penicillium, Alternaria, Aspergillus and Stachybotrys¹. These molds are a type of fungi that reproduce by producing spores. Attached to each spore is a toxin to prevent it from being eaten by another microorganism. Dark, moist environments with cellulose are perfect environments for these molds to grow. Unfortunately, over two hundred and fifty different kinds of molds can grow in the body and cause chronic illness².

Mold can infect your nasal passages
Breathing in mold spores can lead to your respiratory passages being colonized by these fungi. Mold infections have been found in sinus passages³, throat⁴, middle ear⁵, combat wounds⁶, brain⁷, skin⁸, lungs⁹, and meninges¹⁰. Mold also produces toxins which can create debilitating symptoms.

Mold toxins are small enough to get into remote places throughout the body
As mold grows, it produces spores and toxins. Mold toxins can wander everywhere in your body which can produce symptoms of brain fog, aches and pains, allergies, fatigue, and inflammation. These symptoms can migrate from one part of the body to the next. Unfortunately, some people are unable to eliminate these toxins because they lack the right genes.

Mold toxins accumulate faster in people who are lacking specific HLA genes
Human Leukocyte Antigen (HLA) genes help your immune system to identify mold toxins and produce antibodies to eliminate them. Approximately 25% of patients are lacking the specific HLA genes to eliminate mold toxins¹¹. In this subgroup of patients, symptoms can appear quite rapidly due to elevated levels of toxins aggravating symptoms of pain, brain fog, and fatigue. Patients that have immune systems already burdened by other infections are especially vulnerable.

Patients with a compromised immune system are at much greater risk of contracting a mold infection
Patients with a weak or compromised immune system are at a greater risk of becoming very ill or possibly dying from an opportunistic mold infection. Patients diagnosed with an invasive Aspergillus mold infection can receive a variety of antifungal medications including: voriconazole, liposomal amphotericin B, posaconazole, itraconazole, caspofungin, or micafungin. Unfortunately, these antifungal medications can produce undesirable side effects like fever, rigors, chills, myalgias, arthralgias, bronchospasm, nausea, vomiting, headaches, hallucinations, kidney toxicity, and liver toxicity¹². Aspergillus can also produce slimy biofilms to become more drug resistant¹³.

What else besides antifungal medications can help patients overcome a toxic mold infection?

Concentrated spice oils are effective at stopping a mold infection
Kitchen spices contain many natural compounds that are effective at killing mold and inhibiting their toxins. Studies show that when these spices are distilled into essential oils, these compounds are much more effective at inhibiting mold and its toxins compared to the raw spice itself. The volatile nature of essential oils enables them to penetrate into the lungs, nervous system, and other hard to reach areas of the body where mold has taken hold. Here are four essential oils that have anti-mold and anti-toxin properties.

Anti-fungal spice essential oil #1: Sage (S. Officinalis L.), Chinese name: Shu Wei Cao¹⁴
The properties of this spice herb are bitter, acrid, and neutral. This herb is used to clear infection, promote circulation and regulate the menses. It has detoxification properties and reduces swelling. Sage is also used to treat jaundice, red or white diarrhea, vaginal discharge due to infection, irregular menstruation, dysmenorrheal, sores, swollen boils, and injuries from impacts. This herb is also used to improve memory, enhance mnemonic performance and helps elevate mood.

The whole herb contains these compounds: β-sitosterol, β-sitosterol glucoside, ursolic acid, oleanolic acid, 2α-hydroxyursolic acid, tormentic acid, caffeic acid, maslinic acid, ethyl-β-D-galactopyranoside. The essential oil can contain α-thujone, camphor, and up to 2.5% ketone and borneol. Sage essential oil is best used externally because α-thujone can be toxic if taken internally.

In one study, sage essential oil is effective at inhibiting the growth of these mold/fungi: Aspergillus niger, Aspergillus terreus, Candida albicans, and Fusarium species¹⁵. In another study, sage essential oil at 2 mg/ml had a strong antifungal effect against Alternaria alternate and reduced Aspergillus parasiticus growth by 87% and inhibited aflatoxin production by 96%¹⁵. In another study, sage essential oil was highly effective at killing Penicillium verrucosum believed to be due to the compounds α-thujone and camphor¹⁶.

Anti-fungal spice essential oil #2: Thyme, Chinese name: Bai Li Xiang¹⁸
The properties of this spice herb are bitter, pungent, and warming. It is used to: transform mucus, strengthen the spleen, strengthen the lungs, warm the middle, and expel cold mucus. Thyme stimulates the production of white blood cells and strengthens immunity. This oil is very beneficial for the heart, valves, and is an anti spasmodic. It also reduces blood pressure. Thyme is widely used in food and is non-toxic¹⁹. This spice contains the following compounds, thymol, p-Cymene, myrcene, borneol and linalool²⁰.

In one study, thyme essential oil was highly effective at killing intracellular Candida albicans²¹. In another study, the essential oil was effective at killing Aspergillus species. and inhibiting aflatoxin production²², and inhibiting mold spore germination²³. A third study showed thyme essential oil as effective at inhibiting multiple Penicillum species²⁴. Thyme essential oil has been used internally safely and effectively with patients struggling with chronic mold infections.

Anti-fungal spice essential oil #3: Clove, Chinese name: Ding Xiang²⁵
The properties of this spice herb are acrid and warm. It is used to warm the abdomen and relieve pain. Clove is also used to treat hiccups, nausea, morning sickness, vomiting, and diarrhea. This herb is also used to treat impotence, and coldness in the body and extremities. It also promotes digestion by increasing bile and gastric acid secretions. Clove is also used topically to treat toothache. The essential oil has anti-asthmatic properties.

This herb is contraindicated in cases of fever and excess internal heat accompanied with symptoms of dryness. Side effects of this herb include dizziness, palpitations, chest oppression, headache, perspiration, decreased blood pressure, and skin rash. Clove has an inhibitory effect against Vibrio cholerae, Bacillus anthracis, Salmonella typhi, Corynebacterium diptheriae, Bacillus dysenteriae, E. coli, Bacillus subtilis, and Staphlococcus aureus.

Essential oil of clove contains these compounds: eugenol, caryophyllene, acetyleugenol, α- caryophyllene, and chavicol. In one study, clove essential oil inhibits Candida, Aspergillus, and some dematophytes including fluconazole resistant strains²⁶. In another study, the compound eugenol was effective at inhibiting Fusarium moniliforme, Fusarium oxysporum, Aspergillus species, Mucor species, Trichophyton rubrum and Microsporum gypseum²⁷. In a third study, clove essential oil increased the effectiveness of fluconazole and voriconazole against multiple Candida species²⁸. In another study, this essential oil was effective at inhibiting drug resistant Candida biofilms²⁹. Low doses of clove essential oil have been used safely and effectively for years with patients diagnosed with Lyme disease, parasites, and mold toxicity.

Anti-fungal spice essential oil #4: Cinnamon, Chinese name: Rou Gui³⁰
The properties of this spice herb are acrid, sweet, and hot. This herb is used to treat a wide variety of disorders including intolerance to cold, cold extremities, weakness, soreness and coldness of the low back and knees, impotence, lack of libido, excess urine production, and loose stools. It is also used to treat wheezing, asthma, labored breathing, swelling, and profuse phlegm. Cinnamon is also used for dizziness, flushed face, sore throat, and coldness in the lower extremities.

This herb also treats epigastric and abdominal pain, vomiting, diarrhea, gas, bloating, slow digestion, hernia pain, and spasmodic pain in the stomach and intestines. It is also used to treat hypercoagulation, irregular menstruation, amenorrhea, dysmenorrhea, postpartum pain, external injuries, trauma, deep rooted sores, psoriasis, and feelings of oppression in the abdomen.

This herb contains the following compounds: cinnamic aldehyde, cinnamic acid, cinnamyl acetate, phenylpropyl acetate, cinncassiol-A, -B, -C1, -C2, -C3, cinnzelanine, and cinnzeylanol.

Cinnamon is contraindicated during pregnancy and in patients with signs of excess heat, excess dryness, and excess bleeding. Excess amount of cinnamon can result in symptoms of flushed face, red eyes, dry mouth and tongue, bleeding, nausea, vomiting, abdominal pain, excess urination, anuria, burning sensations upon urination, excess serum proteins in the urine, dizziness, blurred vision, and numbness of the tongue.

Intravenous cinnamon reduced blood pressure, decreased heart rate, peripheral vasodilation, and decreased vessel resistance within 3-5 minutes. Subcutaneous injection of cinnamon in dogs increased the white blood cell count by 150 – 200%. This herb has an inhibitory effect on dermatophytes, pathogenic fungi, and many gram positive bacteria. In a rat study, essential oil of cinnamon has an analgesic and sedative effect.

Cinnamon bark essential oil was more effective at inhibiting more Aspergillus and Penicillium species than cinnamon leaf essential oil³¹. Cinnamon bark essential oil inhibits Aspergillus species and aflatoxin, aflatoxin-B1, and aflatoxin-G1 production. These toxins are inhibited because the essential oil binds to the DNA of aflatoxins. Also, this essential oil reacts with reactive oxygen species produced by aflatoxins, which has a protective effect on cells³². In another study, cinnamon bark essential oil was the most effective against oral isolates of Candida albicans³³. Another study demonstrated that cinnamon bark essential oil was more effective against fluconazole susceptible Candida species than against fluconazole resistant Candida species³⁴. Low dilutions of cinnamon essential oil have been taken internally by people diagnosed with mold toxicity safely with out side-effects.

The right combination of essential oils can help you to overcome a toxic mold infection
Just like cleaning out a guinea pig habitat with a pressure washer, a combination of anti-mold/fungal and anti-toxin essential oils can help you penetrate, kill, and detoxify a hidden mold infection. Since some of these essential oils come with cautions on their use, work with a herbalist knowledgeable in essential oils and chronic fungal infections to develop a proper, safe, and effective essential oil strategy for your condition.

>> Next step: Come to our evening lecture:  Getting Rid of Lyme Disease in Frederick, Maryland on Monday November 5th at 6pm to learn more about natural methods for relieving pain, insomnia, fatigue, and brain fog caused by Lyme disease, mold toxins, and parasites.  https://goodbyelyme.com/events/get_rid_lyme

1. Shoemaker, Ritchie. “Molds, Mycotoxins, & More” https://www.survivingmold.com/diagnosis/molds-mycotoxins-more
2. Netkovski J, Shirgoska B. Fungal rhinosinusitis. Prilozi. 2012 Jul;33(1):187-91. https://www.ncbi.nlm.nih.gov/pubmed/22952104
3. Netkovski, p. 187.
4. Shin SY, Ye YM, Eun YG, Kim SW, Cho JS, Park HS. Local IgE-mediated hypersensitivity to Alternaria in pediatric adenoid tissue. Int J Pediatr Otorhinolaryngol. 2012 Oct;76(10):1423-8. doi: 10.1016/j.ijporl.2012.06.015. Epub 2012 Jul 6. https://www.ncbi.nlm.nih.gov/pubmed/22770595
5. Murakami A, Tutumi T, Watanabe K. Middle ear effusion and fungi. Ann Otol Rhinol Laryngol. 2012 Sep;121(9):609-14. https://www.ncbi.nlm.nih.gov/pubmed/23012900
6. Warkentien T, Rodriguez C, Lloyd B, Wells J, Weintrob A, Dunne JR, Ganesan A, Li P, Bradley W, Gaskins LJ, Seillier-Moiseiwitsch F, Murray CK, Millar EV, Keenan B, Paolino K, Fleming M, Hospenthal DR, Wortmann GW, Landrum ML, Kortepeter MG, Tribble DR; for the Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group. Invasive Mold Infections Following Combat-related Injuries. Clin Infect Dis. 2012 Oct 5. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/23042971
7. Huang WM, Fan YM, Li W, Yang WW. Brain abscess caused by Cladophialophora bantiana in China. J Med Microbiol. 2011 Dec;60(Pt 12):1872-4. Epub 2011 Aug 18. https://www.ncbi.nlm.nih.gov/pubmed/21852529
8. Kelly D. Craven,1,† Heriberto Vélëz,1 Yangrae Cho,2 Christopher B. Lawrence,2 and Thomas K. Mitchell. Anastomosis Is Required for Virulence of the Fungal Necrotroph Alternaria brassicicola. Eukaryot Cell. 2008 April; 7(4): 675–683. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292617/
9. Buess M, Cathomas G, Halter J, Junker L, Grendelmeier P, Tamm M, Stolz D. Aspergillus-PCR in bronchoalveolar lavage for detection of invasive pulmonary aspergillosis in immunocompromised patients. BMC Infect Dis. 2012 Oct 2;12(1):237. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/23031334
10. Brown. David. “Meningitis cases increase; very rare fungus identified” Washington Post. 12 Oct. 2012.  https://www.washingtonpost.com/national/health-science/meningitis-cases-increase-very-rare-fungus-identified/2012/10/11/b44a7b1c-13e5-11e2-ba83-a7a396e6b2a7_story.html
11. R. Shoemaker. Surviving Mold. p. x (Foreward).
12. Thomas J. Walsh, EJ. Anaissie, D. Denning, R. Herbrecht, D. Kontoyiannis, K. Marr, V. Morrison, B. Segal, W. Steinbach, D. Stevens, J. van Burik, J. Wingard, T. Patterson. Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America Clin Infect Dis. (2008) 46(3): 327-360 doi:10.1086/525258 https://cid.oxfordjournals.org/content/46/3/327.1.full
13. Fanning S, Mitchell AP (2012) Fungal Biofilms. PLoS Pathog 8(4): e1002585. doi:10.1371/journal.ppat.1002585
14. Joe Hing kwok Chu. shu wei cao. Complementary and Alternative Healing University. https://thedao.com/shu_wei_cao.htm
15. Sage. The Genus Salvia. Edited by Spiridon E . Kintzios. CRC Press 2000. Print ISBN: 978-90-5823-005-8. Vol 11, p. 146.
16. Farag, R.S., Daw, Z.Y. and Abo-Raya, S.H. (1989b). Influence of Some Spice Essential Oils on Aspergillus Parasiticus Growth and Production of Aflatoxins in a Synthetic Medium. Journal of Food Science, 54 (1), 74–76.
17. Sibel Ozcakmak, M. Dervisoglu, and A Yilmaz. Antifungal activity of lemon balm and sage essential oils on the growth of ochratoxigenic Penicillium verrucosum. African Journal of Microbiology Research, 30 March, 2012. https://www.academicjournals.org/AJMR, DOI: 10.5897/AJMR12.569 Vol. 6(12), p. 3082
18. Qi Food Thyme. https://www.qifood.eu/en/aliments/212_thymian
19. Kassner, P. Essential Oil Description. Jan 2011.
20. Thyme. https://en.wikipedia.org/wiki/Thyme
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22. Alizadeh A, Zamani E, Sharaifi R, Javan-Nikkhah M, Nazari S. Antifungal activity of some essential oils against toxigenic Aspergillus species. Commun Agric Appl Biol Sci. 2010;75(4):761-7. https://www.ncbi.nlm.nih.gov/pubmed/21534488
23. Paster, N., Juven, B. J., Shaaya, E., Menasherov, M., Nitzan, R., Weisslowicz, H. and Ravid, U. (1990), Inhibitory effect of oregano and thyme essential oils on moulds and foodborne bacteria. Letters in Applied Microbiology, 11: 33–37. doi: 10.1111/j.1472-765X.1990.tb00130.x https://onlinelibrary.wiley.com/doi/10.1111/j.1472-765X.1990.tb00130.x/abstract
24. Lixandru BE, Drăcea NO, et al. Antimicrobial activity of plant essential oils against bacterial and fungal species involved in food poisoning and/or food decay. Roum Arch Microbiol Immunol. 2010 Oct-Dec;69(4):224-30. https://www.ncbi.nlm.nih.gov/pubmed/21462837
25. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 461 – 462.
26.  Pinto E, Vale-Silva L, Cavaleiro C, Salgueiro L. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. J Med Microbiol. 2009 Nov;58(Pt 11):1454-62. Epub 2009 Jul 9. https://www.ncbi.nlm.nih.gov/pubmed/19589904
27. Inder Singh Rana, A. S. Rana, R. C. Rajak.  Evaluation of antifungal activity in essential oil of the Syzygium aromaticum (L.) by extraction, purification and analysis of its main component eugenol. Brazilian Journal of Microbiology (2011) 42: 1269-1277 ISSN 1517-8382 https://www.scielo.br/scielo.php?pid=S1517-83822011000400004&script=sci_arttext
28. Rózalska B, Sadowska B, Wieckowska-Szakiel M, Budzyńska A. [The synergism of antifungals and essential oils against Candida spp. evaluated by a modified gradient-diffusion method]. Med Dosw Mikrobiol. 2011;63(2):163-9. https://www.ncbi.nlm.nih.gov/pubmed/22184911
29. Khan MS, Ahmad I. Biofilm inhibition by Cymbopogon citratus and Syzygium aromaticum essential oils in the strains of Candida albicans. J Ethnopharmacol. 2012 Mar 27;140(2):416-23. Epub 2012 Feb 2. https://www.ncbi.nlm.nih.gov/pubmed/22326355
30. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 447 – 449.
31. Singh G, Maurya S, DeLampasona MP, Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food Chem Toxicol. 2007 Sep;45(9):1650-61. Epub 2007 Feb 28. https://www.ncbi.nlm.nih.gov/pubmed/17408833
32. Lokman Alpsoy. Inhibitory Effect of Essential Oil on Aflatoxin Activity. African Journal of Biotechnology Vol. 9(17), pp. 2474-2481, 19 April, 2010 www.ajol.info/index.php/ajb/article/view/79702/69978
33. Carvalhinho S, Costa AM, Coelho AC, Martins E, Sampaio A. Susceptibilities of Candida albicans mouth isolates to antifungal agents, essentials oils and mouth rinses. Mycopathologia. 2012 Jul;174(1):69-76. Epub 2012 Jan 14. https://www.ncbi.nlm.nih.gov/pubmed/22246961
34. Pozzatti P, Scheid LA, Spader TB, Atayde ML, Santurio JM, Alves SH. In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp. Can J Microbiol. 2008 Nov;54(11):950-6. https://www.ncbi.nlm.nih.gov/pubmed/18997851

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For people that are struggling with an antibiotic resistant Klebsiella infection
by Greg Lee

When I was a kid, I used to watch Saturday afternoon monster movies on TV. Many of these monsters were often normal reptiles that mutated into huge creatures because of scientific experiments, nuclear fallout, or toxic chemicals. Towering above cities, they would squash buildings, scare citizens, and get attacked by the military. Attacking them with missiles, bombs, and tanks merely aggravated these monsters into destroying more buildings. All efforts appeared to fail to stop these hulking monsters.

How are unstoppable movie monsters similar to a drug resistant Klebsiella infection?

Unfortunately unstoppable monsters don’t have to be huge to cause big problems
A small bacteria called Klebsiella pneumoniae is infecting and claiming lives of sick patients at the National Institutes of Health (NIH)¹. Despite the best efforts to isolate patients and eliminate all environmental sources, this germ is still being spread to more patients. The latest strain of Klebsiella pneumoniae has shown tremendous antibiotic resistance. Even experimental antibiotics have failed to stop this infection from taking more lives. Unfortunately, this infection can protect itself by making a slimy shield.

Klebsiella has the ability to produce slimy biofilms to protect itself²
Drug resistance infections can protect themselves against antibiotics by making shields of slime called biofilms³. Some researchers estimate that biofilms can increase drug resistance a thousand fold⁴. Within biofilms, germs can acquire drug resistance by swapping genes with other organisms or sampling antibiotics and developing resistance⁵. In one patient, Klebsiella appeared to develop antibiotic resistance in about a week⁶. In immune compromised patients, overcoming Klebsiella drug resistant infections and biofilms can be the difference between life and death.

What else besides antibiotics can help patients overcome a drug resistant Klebsiella infection?

Concentrated food and herb extracts are effective at fighting drug resistant Klebsiella infections⁷
In one study, aqueous extracts of lemon and clove leaf were 90% effective against Klebsiella⁸. In another study, Salvia officinalis, L. essential oil was 100% effective against Klebsiella⁹. Essential oil of oregano also inhibits Klebsiella¹⁰. Garlic oil is also effective against drug resistant Klebsiella¹¹. Many of these herbs and essential oils have been used safely and effectively in patients with chronic infections. When fighting drug resistant infections, not only do you need effective anti-Klebsiella medicines, you also need to have an effective anti-biofilm strategy.

Combining natural anti-Klebsiella remedies with anti-biofilm medicines will increase the likelihood of overcome drug resistant infections
Infections have been shown to be able to produce or hide within biofilms to protect themselves against antibiotic treatment¹². For over twelve years, we have treated patients diagnosed with Lyme disease biofilms and other tick borne infections. We have also helped several patients to treat drug resistant infections like methicillin-resistant staphylococcus aureus (MRSA), atovaquone resistant Babesia, and multiple drug resistant Candida. Anti-biofilm herbs and supplements have helped these patients to reduce the severity of symptoms and diminished their recurrence. Given that different infections produce biofilms with different compositions¹³, here are some suggested remedies that may help cut through drug resistant Klebsiella biofilms.

Anti-biofilm strategy #1: Use herbs for cutting through biofilms
A high school student wins second place in the 2007 – 2008 Siemens National Science Competition with her discovery that an ancient herb called Terminalia Chebula, Chinese name: He Zi, cuts through biofilms and kills Pseudomonas aeruginosa¹⁴. One research study shows that compounds in the herb Andrographis paniculata have anti-biofilm properties¹⁵. A topical garlic ointment inhibits biofilms in a burn healing study¹⁶. Patients that apply minced raw garlic mixed with olive oil and Vaseline or Unpetroleum to the bottoms of their feet also report significant reductions in symptoms of fatigue and brain fog. Not only herbs help to breakdown biofilms, but also essential oils.

Anti-biofilm strategy #2: Use essential oils for dissolving biofilms
Essential oils contain solvents called phenols which may enable them to cut through biofilms. Given their ability to disseminate rapidly through tissues, essential oils can target biofilms anywhere in the body. Essential oils are also among most potent of anti-infectious agents against viruses, bacteria, parasites and fungi.

Eucalyptus essential oil has been effective against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), E. coli, Pseudomonas aeruginosa, and Candida albicans biofilms¹⁷. Peppermint¹⁸, clove bud¹⁹ and tea tree²⁰ essential oils are also effective against Candida biofilms. Lemongrass essential oil is effective against Staphylococcus aureus biofilms²¹. Eucalyptus, peppermint, clove bud, tea tree, and lemongrass essential oils have been used safely and effectively both topically and internally in Lyme disease patients diagnosed with biofilm colonies. Interrupting how bacteria and other germs communicate also helps to inhibit biofilms from forming.

Anti-biofilm strategy #3: Use herbs and essential oils for disrupting Quorum Sensing communication
Bacteria use chemical signals to collaborate in order to form biofilms through a process called Quorum Sensing (QS). Many foods, herbs, and essential oils have been shown to inhibit Quorum Sensing, and are referred to as QS inhibitors. Rose, geranium, lavender and rosemary essential oils are potent QS inhibitors against E. coli²². Clove bud, followed by cinnamon, lavender and peppermint are effective QS inhibitors against Pseudomonas aeruginosa²³.

The following Chinese herbs have QS inhibiting properties against Pseudomonas aeruginosa: Prunus armeniaca, Prunella vulgaris, Nelumbo nucifera, Panax notoginseng root, Panax notoginseng flower, Punica granatum, Areca catechu, and Imperata cylindrical²⁴. The proper combination of herbs and essential oils can help sick patients to overcome a drug resistant Klebsiella infection.

The right combination of essential oils and herbs can help you to overcome a drug-resistant Klebsiella infection
Towards the end of a scary monster movie, the rampaging monster is usually outwitted or another helpful creature appears to stop the rampage. Through using a combination of anti-Klebsiella and anti-biofilm herbs and essential oils, you have more options for cutting through biofilm shields and stopping a drug-resistant Klebsiella superbug. Since many of these natural remedies come with cautions on their use, work with a herbalist knowledgeable in using anti-microbial essential oils to develop a proper, safe, and effective strategy for your condition.

>> Next step: Come to our evening lecture:  Getting Rid of Lyme Disease in Frederick, Maryland on Monday October 1st at 6pm to learn more about natural methods for stopping co-infections and Lyme disease. https://goodbyelyme.com/events/get_rid_lyme

1.Vastag, Brian and L. Sun. “NIH Superbug Claims 7th Victim.” Washington Post. 14 Sept. 2012. https://www.washingtonpost.com/national/health-science/nih-superbug-claims-7th-victim/2012/09/14/09b3742e-fe9b-11e1-b153-218509a954e1_story.html
2. Wu M-C, Lin T-L, Hsieh P-F, Yang H-C, Wang J-T (2011) Isolation of Genes Involved in Biofilm Formation of a Klebsiella pneumoniae Strain Causing Pyogenic Liver Abscess. PLoS ONE 6(8): e23500. doi:10.1371/journal.pone.0023500 https://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0023500
3. Høiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O. Antibiotic resistance of bacterial biofilms. Int J Antimicrob Agents. 2010 Apr;35(4):322-32. Epub 2010 Feb 10.  https://www.ncbi.nlm.nih.gov/pubmed/20149602
4. Stewart PS, Costerton JW (July 2001). Antibiotic resistance of bacteria in biofilms. Lancet 358 (9276): 135–8. doi:10.1016/S0140-6736(01)05321-1. https://www.ncbi.nlm.nih.gov/pubmed/11463434
5. Lee, Greg. Disrupting Biofilms to Stop Recurring Lyme Disease Symptoms. E-report. 2010 June. https://goodbyelyme.com/products.
6. Vastag, p1.
7. Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PA, Wiltfang J, Fickenscher H, Sherry E. The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Craniomaxillofac Surg. 2009 Oct;37(7):392-7. Epub 2009 May 26. https://www.ncbi.nlm.nih.gov/pubmed/19473851
8. Sharmeen, R., Hossain, M., Rahman, M., Foysal, M., Miah, M.. In-vitro antibacterial activity of herbal aqueous extract against multi-drug resistant Klebsiella sp. isolated from human clinical samples. International Current Pharmaceutical Journal, North America, 1, May. 2012. https://www.banglajol.info/index.php/ICPJ/article/view/10534.
9. Pereira RS, Sumita TC, Furlan MR, Jorge AO, Ueno M. Antibacterial activity of essential oils on microorganisms isolated from urinary tract infection. Rev Saude Publica. 2004 Apr;38(2):326-8. Epub 2004 Apr 26. https://www.ncbi.nlm.nih.gov/pubmed/15122392
10. Chaudhry, N.M., A. Sabahat and T. Perween, 2007. Antibacterial effects of Oregano (Origanum vulgare) Against Gram negative Bacilli.  Pak. J. Bot., 39(2): 609-613. www.pakbs.org/pjbot/PDFs/39(2)/PJB39(2)609.pdf
11. Shyh-ming Tsaoa and M. Yin. In vitro activity of garlic oil and four diallyl sulphides against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. J. Antimicrob. Chemother. (2001) 47 (5): 665-670. doi: 10.1093/jac/47.5.665 https://www.ncbi.nlm.nih.gov/pubmed/11328781
12. Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, Rossi M, Stricker RB. Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi. Infect Drug Resist. 2011;4:97-113. Epub 2011 May 3. https://www.ncbi.nlm.nih.gov/pubmed/21753890
13. Domenech M, García E, Prieto A, Moscoso M. Insight into the composition of the intercellular matrix of Streptococcus pneumoniae biofilms. Environ Microbiol. 2012 Jul 30. doi: 10.1111/j.1462-2920.2012.02853.x. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/22913814
14. Gadvini, Madhavi. Engineering a Novel-Inhibitor of Biofilm Encapsulated Pathogens. Siemens National Science Competition 2007-2008. https://www.synapticdigitalvideo.com/siemens/2006/webcasts/sc2006_vodw_madhavi_gavini.html
15. Jiang X, Yu P, Jiang J, Zhang Z, Wang Z, Yang Z, Tian Z, Wright SC, Larrick JW, Wang Y. Synthesis and evaluation of antibacterial activities of andrographolide analogues. Eur J Med Chem. 2009 Jul;44(7):2936-43. Epub 2008 Dec 25. https://www.ncbi.nlm.nih.gov/pubmed/19152987
16. Nidadavolu P, Amor W, Tran PL, Dertien J, Colmer-Hamood JA, Hamood AN. Garlic ointment inhibits biofilm formation by bacterial pathogens from burn wounds. J Med Microbiol. 2012 May;61(Pt 5):662-71. Epub 2012 Feb 2. https://www.ncbi.nlm.nih.gov/pubmed/22301617
17. Hendry ER, Worthington T, Conway BR, Lambert PA. Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm cultures. J Antimicrob Chemother. 2009 Dec;64(6):1219-25. Epub 2009 Oct 16. https://www.ncbi.nlm.nih.gov/pubmed/19837714
18. Agarwal V, Lal P, Pruthi V. Prevention of Candida albicans biofilm by plant oils. Mycopathologia. 2008 Jan;165(1):13-9. Epub 2007 Oct 30. https://www.ncbi.nlm.nih.gov/pubmed/17968673
19. Khan MS, Ahmad I. Biofilm inhibition by Cymbopogon citratus and Syzygium aromaticum essential oils in the strains of Candida albicans. J Ethnopharmacol. 2012 Mar 27;140(2):416-23. Epub 2012 Feb 2. https://www.ncbi.nlm.nih.gov/pubmed/22326355
20. Ramage G, Milligan S, Lappin DF, Sherry L, Sweeney P, Williams C, Bagg J, Culshaw S. Antifungal, cytotoxic, and immunomodulatory properties of tea tree oil and its derivative components: potential role in management of oral candidosis in cancer patients. Front Microbiol. 2012;3:220. Epub 2012 Jun 18. https://www.ncbi.nlm.nih.gov/pubmed/22719736
21. Adukwu EC, Allen SC, Phillips CA. The anti-biofilm activity of lemongrass (Cymbopogon flexuosus) and grapefruit (Citrus paradisi) essential oils against five strains of Staphylococcus aureus. J Appl Microbiol. 2012 Aug 1. doi: 10.1111/j.1365-2672.2012.05418.x. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/22862808
22. Szabó MA, Varga GZ, Hohmann J, Schelz Z, Szegedi E, Amaral L, Molnár J. Inhibition of quorum-sensing signals by essential oils. Phytother Res. 2010 May;24(5):782-6. https://www.ncbi.nlm.nih.gov/pubmed/19827025
23. Khan MS, Zahin M, Hasan S, Husain FM, Ahmad I. Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil. Lett Appl Microbiol. 2009 Sep;49(3):354-60. Epub 2009 Jul 14. https://www.ncbi.nlm.nih.gov/pubmed/19627477
24. Koh KH, Tham FY. Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity. J Microbiol Immunol Infect. 2011 Apr;44(2):144-8. Epub 2011 Jan 14. https://www.ncbi.nlm.nih.gov/pubmed/21439518

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For people with persistent lung problems or arthritis due to a Chlamydia co-infection
by Greg Lee

Have you ever accidentally brought home dented cans from the grocery store? As a kid, I remember being told to never get them because the dents could mean the food is spoiled inside. I really learned my lesson after opening a dented can of tomato soup that contained yucky foul-smelling brown-red glop.

How is a can of spoiled tomato soup just like a lurking Chlamydia pneumonia co-infection?

Similar to spoiled tomato soup hiding inside a dented can, Chlamydia can lurk inside ticks
Chlamydia pneumonia is a bacteria that can be transmitted through an infected tick¹ or from an infected person through inhaling contaminated droplets. This infection is one of the pathogens that  can cause pneumonia. Once inside a human host, C. pneumonia is taken up by cells in an endosome pouch to destroy the bacteria through phagocytosis. Unfortunately, it begins to replicate within the endosome. C. pneumoniae can infect elderly, disabled, and healthy adults. What are the symptoms of a Chlamydia pneumonia infection?

Chlamydia can create symptoms similar to Lyme disease
Some people with C. pneumonia may not have any symptoms at all. This infection can also create symptoms of asthma and pneumonia in the respiratory system. 60% of Lyme disease patients have tested positive for C. pneumonia at Infectolab in Germany². It can also present symptoms similar to Lyme disease including fatigue, meningitis, encephalitis, arthritis, and myocarditis. C. pneumonia has also been associated with a higher risk of lung cancer³ and atherosclerosis⁴, It has been found in the cerebral spinal fluid of Multiple Sclerosis patients⁵ and in patients with Alzheimer’s⁶. Unfortunately, patients with C. pneumonia can experience recurring symptoms despite prolonged antibiotic treatment⁷.

Chlamydia can be difficult to eliminate completely with antibiotics
Patients diagnosed with C. pneumonia are prescribed antibiotics like azithromycin, clarithromycin, or levofloxacin. Unfortunately, relapsing Chlamydia symptoms may be due to an insufficient dose or too short a duration of antibiotics⁸. Another reason why this infection can persist is because C. pneumonia can acquire drug resistance through gene transfer⁹ and it can hide under biofilms¹⁰.

What else can help you to stop a relapsing Chlamydia infection?

Research on the natural compound betulin shows that it inhibits Chlamydia
Betulin is a natual triterpene compound that has shown to inhibit intracellular Chlamydia in one in vitro study¹¹. This compound protects plants against bacteria and viruses¹² and is found in several medicinal herbs. Patients that have been diagnosed with recurring C. pneumonia symptoms have found that these herbs with betulin help to significantly reduce their chronic symptoms of fatigue, arthritis, inflammation, and asthmatic shortness of breath.

Herb #1: Ligustrum seed, Chinese name: Nu zhen zi¹⁴
The properties of this herb are sweet, bitter, and cool. This herb is used to strengthen the liver, kidneys, and vital essence or jing. Ligustrum seed contains betulin¹⁵ which inhibits C. pneumonia. It has been used to treat dizziness, tinnitus, vertigo, premature gray hair, and soreness and weakness of the low back and knees. This herb is suitable for use over a long period of time and is very safe.

Ligustrum seed is very well suited for symptoms of dryness and excess internal heat. These include menopause, irritability, tidal fever, hot flashes, thirst, night sweats, mood swings, bones that feel like they are being steamed. This herb helps with eye problems like diminished vision, blurred vision, and dry eyes.

In research studies, this herb increases white blood cells especially those called neutrophils. In mice studies, it increases the production of blood. This herb has been used to reduce plasma glucose levels in diabetes studies and has been used to treat diabetes mellitius. It also reduces plasma cholesterol and triglyceride levels in rabbit studies. In other mouse studies, Ligustrum seed reduces inflammation, swelling, and permeability of vessels. This herb lowers elevated liver enzyme levels and prevents liver damage.

Ligustrum seed has an inhibitory effect against Staphylococcus aureus, Bacillus dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, and E. coli. This herb is contraindicated for patients with internal cold symptoms in the stomach which can be characterized by diarrhea. Since this herb lowers plasma glucose levels, it should be used with caution with insulin, sulfonylureas, and other antidiabetic medications like tolbutamide, glipizide, and glyburide, as it may have a synergistic effect resulting in hypoglycemia.

Herb #2: Lotus rhizome node, Chinese name: Ou jie¹⁶
The properties of this herb are sweet, astringent, and neutral. This herb has been used in Chinese food recipes for centuries. This herb contains betulin which is effective at inhibiting C. pneumonia¹⁷. It is used to stop bleeding disorders, restrain blood leakage, and disperse blood stasis (hypercoagulation). The raw herb clears heat and cools the blood. The charred version of this herb is used to treat bleeding disorders along with symptoms of internal coldness.

Lotus rhizome node has been used to treat symptoms of coughing up blood (hemoptysis), vomiting of blood (hematemesis), nose bleeds (epistaxis), blood in the urine (hematuria), and blood in the stools (hematochezia). Clinical research has shown that Lotus rhizome node is effective at treating bleeding hemorrhoids, bleeding from the eyes, and nasal polyps.

Herb #3: Chaga mushroom, Chinese name: Bai Hua Rong
Chaga mushroom purifies the blood and relieves pain. Used medicinally for over five hundred years in Russia, this fungi contains betulin and betulinic acid¹⁸ which inhibit C. pneumonia. It has over two hundred different compounds that have anti-cancer, anti-bacterial, anti-viral, anti-inflammatory, immunostimulating, cytotoxic, anti-platelet aggregation, anti-diabetic, and anti-dementia properties^19,20.

Chaga has also been burned topically on the skin to treat arthritis inflammation²¹ similar to moxabustion in Chinese medicine. In research studies on animals, chaga has been effective in reducing several kinds of cancers: lung²², colon²³, Hodgkin’s lymphoma²⁴, and carcinoma²⁵. It inhibits HIV²⁶ and in other studies, chaga scavenges free radicals and reduces oxidative stress²⁷.

How do you know if these herbs are helping to stop your Chlamydia infection?

Patients report a significant reduction of Chlamydia symptoms
After taking one or more of the herbs listed above with anti-biofilm, toxin clearing and immune modulating herbs, several Lyme patients co-infected with Chlamydia have reported decreased joint pain, increased energy, increased breathing capacity, and greater mental clarity in as little as a few weeks. The right combination of herbs can help reduce stubborn Chlamydia symptoms.

The right herbs may help you to stop a lurking Chlamydia infection
Just like throwing out the dented cans of food from your pantry, the proper combination of herbs may help you to eliminate a lurking Chlamydia infection. Since some of these herbs come with cautions on their use, work with a Lyme literate herbalist to develop a proper, safe, and effective herbal strategy for your condition.

>> Next step: Click here to take our Stealthy Co-infection Quiz to see which tick infections may be causing your symptoms.

P.S. Do you have experiences where treatment or remedies helped you reduce symptoms from a Chlamydia infection? Tell us about it.

1. Facco F, Grazi G, Bonassi S, Magnani M, Di Pietro P. Chlamydial and rickettsial transmission through tick bite in children. Lancet. 1992 Apr 18;339(8799):992-3. https://www.ncbi.nlm.nih.gov/pubmed/1348825
2. Schwarzbach, A. Diagnostic and Therapeutical Strategies in Lyme Disease and Multiple Infections by Chlamydia and Mycoplasma. Physicians Roundtable Conference. Tampa, Fl. Jan 2012.
3. Zhan P, Suo LJ, Qian Q, Shen XK, Qiu LX, Yu LK, Song Y. Chlamydia pneumoniae infection and lung cancer risk: a meta-analysis. Eur J Cancer. 2011 Mar;47(5):742-7. Epub 2010 Dec 29. https://www.ncbi.nlm.nih.gov/pubmed/21194924
4. Mussa FF, Chai H, Wang X, Yao Q, Lumsden AB, Chen C. Chlamydia pneumoniae and vascular disease: an update. J Vasc Surg. 2006 Jun;43(6):1301-7. https://www.ncbi.nlm.nih.gov/pubmed/16765261
5. Stratton CW, Wheldon DB. Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae. Trends Microbiol. 2006 Nov;14(11):474-9. Epub 2006 Sep 25. https://www.ncbi.nlm.nih.gov/pubmed/16996738
6. Frykholm BO. On the question of infectious aetiologies for multiple sclerosis, schizophrenia and the chronic fatigue syndrome and their treatment with antibiotics. Med Hypotheses. 2009 Jun;72(6):736-9. Epub 2009 Mar 6. https://www.ncbi.nlm.nih.gov/pubmed/19269110
7. Kutlin A, Roblin PM, Hammerschlag MR. Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection Model. Antimicrob Agents Chemother. 2002 Feb;46(2):409-12. https://www.ncbi.nlm.nih.gov/pubmed/11796350
8. Kutlin, 409.
9. Sandoz KM, Rockey DD. Antibiotic resistance in Chlamydiae. Future Microbiol. 2010 Sep;5(9): 1427-42. https://www.ncbi.nlm.nih.gov/pubmed/20860486
10. Persson GR, Imfeld T. Periodontitis and cardiovascular disease. Ther Umsch. 2008 Feb;65(2):121-6. https://www.ncbi.nlm.nih.gov/pubmed/18517068
11. Salin O, Alakurtti S, Pohjala L, Siiskonen A, Maass V, Maass M, Yli-Kauhaluoma J, Vuorela P. Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae. Biochem Pharmacol. 2010 Oct 15;80(8):1141-51. Epub 2010 Jul 6. https://www.ncbi.nlm.nih.gov/pubmed/20615390
12. Bajaj YPS (ed) Biotechnology in agriculture and forestry. Medicinal and aromatic plants VI. Springer, Berlin Heidelberg New York, p. 193.
13. Rogers, R. The Fungal Pharmacy: The Complete Guide to Medicinal Mushrooms and Lichens of North America. North Atlantic Books, 2012. p. 233.
14. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., pp. 962 – 963.
15. Huang X, Yin Z, Ye W, Shen W. Chemical constituents from fruits of Ligustrum lucidum. Zhongguo Zhong Yao Za Zhi. 2010 Apr;35(7):861-4. https://www.ncbi.nlm.nih.gov/pubmed/20575386
16. Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., pp. 585 – 586.
17. Chaudhuri PK, Singh D. A new triterpenoid from the rhizomes of Nelumbo nucifera. Nat Prod Res. 2012 Apr 19. https://www.ncbi.nlm.nih.gov/pubmed/22512662
18. Inonotus obliquus. https://en.wikipedia.org/wiki/Inonotus_obliquus
19. Lee IK, Yun BS. Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J Antibiot (Tokyo). 2011 May;64(5):349-59. Epub 2011 Feb 9. https://www.ncbi.nlm.nih.gov/pubmed/21304532
20. Inonotus obliquus. https://en.wikipedia.org/wiki/Inonotus_obliquus
21. Rogers, 241.
22. Zhong XH, Wang LB, Sun DZ. Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549. Chin J Integr Med. 2011 Mar;17(3):218-23. Epub 2011 Feb 27. https://www.ncbi.nlm.nih.gov/pubmed/21359924
23. Lemieszek MK, Langner E, Kaczor J, Kandefer-Szerszeń M, Sanecka B, Mazurkiewicz W, Rzeski W. Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies. Int J Med Mushrooms. 2011;13(2):131-43. https://www.ncbi.nlm.nih.gov/pubmed/22135889
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26. Bori ID, Hung HY, Qian K, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry. Tetrahedron Lett. 2012 Apr 11;53(15):1987-1989. https://www.ncbi.nlm.nih.gov/pubmed/22711941
27. Najafzadeh M, Reynolds PD, Baumgartner A, Jerwood D, Anderson D. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease. Biofactors. 2007;31(3-4):191-200. https://www.ncbi.nlm.nih.gov/pubmed/18997282

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Thanks,

Greg