For people with interstitial cystitis, digestion tract inflammation, or fatigue caused by a stealthy adenovirus infection
by Greg Lee
Have you ever seen a set of nested wooden dolls? As you open the biggest doll and you see a smaller one inside, and another, and another. Eventually, you finally discover the tiniest doll inside.
How are nested dolls similar to an adenovirus infection in a person with Lyme disease?
Similar to a set of nested dolls, viruses can hide within larger germs like Lyme bacteria and parasites1
Adenoviruses are a group of viruses that commonly infect the respiratory system, digestion tract, or other organs. A person infected with this virus can present with: fever, diarrhea, rashes, cystitis (bladder infections), pink eye2, or encephalitis3. People with a weakened immune system, respiratory illness, or cardiac disease are at a higher risk from getting symptoms from an adenovirus infection. Transmission can occur by having close contact with infected people, by touching items that have adenoviruses on them and then touching your mouth, nose, or eyes. Given the similar presentation to other bacterial infections, adenovirus can be easily misdiagnosed.
Misdiagnosis of adenovirus patients was greater than 80%
In one study, 88% of children infected with adenovirus were misdiagnosed with a bacterial infection and mistakenly given antibiotics4. Since viruses can be nested within bacterial infections like Lyme disease, antibiotic treatment may actually increase detectable levels of adenovirus.
When larger parasites or bacteria are killed with medications, viral infections have dramatically increased5
In Lyme disease patients that have received extensive antibiotic or anti-parasitic medications, elevated levels of adenovirus have been detected in blood tests and electrodermal scans. If detected in immune compromised patients, they may receive the antiviral medication ribavirin. Unfortunately, ribavirin is not effective against all types of adenovirus.
Adenoviruses employ multiple strategies to evade the immune system and antiviral drugs
Some species of adenovirus are resistant to ribavirin6. Also, adenovirus has the ability to hide within biofilms found on materials used in drinking water systems7. The estimated level of increased antiviral resistance due to biofilms is unknown. Since biofilms may provide an estimated five-thousand fold8 increase to antibiotics, there is likely to be increased antiviral resistance. Since adenoviruses hijack the nucleus of cells to reproduce, they have the ability to disrupt how cells produce immune-modulatory proteins that help to identify viruses, which allows it to escape detection9.
What else besides antiviral medications can help you fight an antiviral resistant, biofilm hiding, and intracellular manipulating adenovirus infection?
Here are three methods for stopping a stealthy adenovirus infection
Fortunately, there are three remedies and treatments that can help to overcome a growing adenovirus infection: essential oils, liposomal antiviral herbs, and Frequency Specific Microcurrent. These methods help to fight antiviral resistant adenovirus species, cut through biofilms, and penetrate into cells and reservoirs where the viruses are causing symptoms.
Strategy #1: Anti-Adenovirus Essential Oils
Two essential oils have been found to inhibit adenoviruses, thyme and cinnamon. Thyme, had a minimum inhibitory concentration (MIC) against adenovirus-5 of 50 µl/ml in one lab study10. Thyme essential oil has antibiofilm properties against other microbes11,12. In another lab study, cinnamaldehyde, which is found in high concentrations in essential oils made from two types of cinnamon bark cinnamomum verum and cinnamomum cassia, had a MIC of 0.0195–0.315 mg/mL against adenovirus-3 in another study13. Cinnamon essential oil also has antibiofilm properties against many different biofilms14,15,16,17. Herbs also have anti-adenovirus properties.
Strategy #2: Liposomal Anti-Adenovirus Herbs
In one study, hot water extracts two herbs Pisum sativum, aka garden peas, and Bauhinia variegata leaves and bark, aka Orchid tree, Camel’s Foot Tree or Mountain-ebony, demonstrated half maximal effective concentrations (EC50) of
143.1 ± 26.1 μg/ml (adenovirus-3)
87.9 ± 11.1 μg/ml (adenovirus-8)
463.9 ± 30.0 μg/ml (adenovirus-11)
190.1 ± 8.9 μg/ml (adenovirus-3)
118.1 ± 10.0 μg/ml (adenovirus-8)
> 500.0 μg/ml (adenovirus-11)18.
In other studies, these herbal compounds inhibited adenovirus-3: cinnamaldehyde from cinnamon19, shikonin from Lithosperm eyrthrorhizon root20, and astragaloside IV from Astragalus membranaceus21. These compounds from sweet basil were effective against multiple types of adenovirus: ursolic acid had an EC50 = 4.2 mg/L on adenovirus-8, apigenin had an EC50 = 11.1 mg/L on adenovirus-3, and linalool had an EC50 = 16.9 mg/L on adenovirus-1122. Ethanol extract of echinacea purpurea inhibited the inflammatory cytokines produce in response to adenovirus-3 and adenovirus-1123.
Processing these herbs into a liposomal mixture increases their ability to penetrate into macrophage cells24, biofilms, joints, and the nervous system25 where adenovirus can hide. Cinnamon is contraindicated in pregnancy, and in cases of excess heat (flushed face, red eyes, dry mouth and tongue) and bleeding26. Lithosperm eyrthrorhizon root is cautioned in people with diarrhea or coldness in the stomach27. Astragalus is contraindicated in cases of excess anger due to liver stagnation, excess heat, coldness in the lower abdomen, lesions caused by excess heat in the blood. This herb is also cautioned in pregnancy28. Sweet basil is contraindicated in pregnancy29. Echinacea is contraindicated in people allergic to ragweed, chrysanthemum, marigolds, or daisies30. In addition to liposomal herbs, Frequency Specific Microcurrent can help eliminate an adenovirus infection.
Strategy #3 Antiviral Frequency Specific Microcurrent
Frequency Specific Microcurrent uses millionth of an amp electrical currents to reduce viral infections and inflammation. Frequencies for reducing viruses, inflammation, and promoting healing are combined with frequencies to target viruses hiding inside organs like the bladder in interstitial cystitis patients, the lungs and heart, and the nervous system in patients with memory and concentration issues. Frequencies can also be used to target intracellular viral infections31. Using multiple remedies and treatment can help to fight off a spreading adenovirus infection.
A combined approach helps to stop a stealthy adenovirus infection
Just like opening up a set of nested dolls to find the tiniest one hidden inside, blood testing or an electro-dermal scan can help to detect an underlying adenovirus infection. Patients that have little improvement on antibiotics for Lyme disease have reported significant relief with anti-adenovirus essential oils, herbs, and frequencies. Persistent symptoms of fatigue and pain and inflammation in the bladder, lungs, digestion system, and nervous system have been markedly reduced with these methods. Since some of these methods have contraindications or cautions or may produce Herxheimer reactions, work with a Lyme literate herbalist and essential oil practitioner to develop a safe and effective strategy for your condition.
>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday March 10th at 6pm to learn more about treatments, essential oils, herbs, and homeopathic remedies for adenovirus, brucellosis, bartonella, Babesia, Lyme disease, mold, parasites, abnormal fatigue, inflammation, and pain. https://goodbyelyme.com/events/get_rid_lyme
- Klinghardt, D. A Deep Look Beyond Lyme. 2012 Physician’s Round Table. January 28th, 2012. Tampa, FL.
- Adenovirus. https://www.cdc.gov/adenovirus/
- Viral encephalitis. https://umm.edu/health/medical/reports/articles/viral-encephalitis
- Treatment of Adenovirus Infections. https://www.stanford.edu/group/virus/adeno/2004takahashi/webpage/Treatment%20of%20Adenoviurs%20Infections.htm
- Klinghardt, D. A Deep Look Beyond Lyme.
- Morfin F., Dupuis-Girod S, Mundweiler S, Falcon D, Carrington D, Sedlacek P, Bierings M, Cetkovsky P, Kroes AC, van Tol MJ, Thouvenot D. In vitro susceptibility of adenovirus to antiviral drugs is species-dependent. Antivir Ther. 2005;10(2):225-9. https://www.ncbi.nlm.nih.gov/pubmed/15865216
- Helmi K., Menard-Szczebara F, Lénès D, Jacob P, Jossent J, Barbot C, Delabre K, Arnal C. Adenovirus, MS2 and PhiX174 interactions with drinking water biofilms developed on PVC, cement and cast iron. Water Sci Technol. 2010;61(12):3198-207. doi: 10.2166/wst.2010.821. https://www.ncbi.nlm.nih.gov/pubmed/20555217
- Del Pozo JL, Rouse MS, Patel R. Bioelectric effect and bacterial biofilms. A systematic review. Int J Artif Organs. 2008 Sep;31(9):786-95. https://www.ncbi.nlm.nih.gov/pubmed/18924090
- Windheim M., Hilgendorf A, Burgert HG. Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways. Curr Top Microbiol Immunol. 2004;273:29-85. https://www.ncbi.nlm.nih.gov/pubmed/14674598
- Horieh Saderi, and Maryam Abbasi, “Evaluation of anti-adenovirus activity of some plants from Lamiaceae family grown in Iran in cell culture,” African Journal of Biotechnology, vol. 10, no. 76, pp. 17546–17550, 2011. https://www.ajol.info/index.php/ajb/article/view/97908
- Soni KA., Oladunjoye A, Nannapaneni R, Schilling MW, Silva JL, Mikel B, Bailey RH. Inhibition and inactivation of Salmonella typhimurium biofilms from polystyrene and stainless steel surfaces by essential oils and phenolic constituent carvacrol. J Food Prot. 2013 Feb;76(2):205-12. doi: 10.4315/0362-028X.JFP-12-196. https://www.ncbi.nlm.nih.gov/pubmed/23433366
- Desai MA., Soni KA, Nannapaneni R, Schilling MW, Silva JL. Reduction of Listeria monocytogenes biofilms on stainless steel and polystyrene surfaces by essential oils. J Food Prot. 2012 Jul;75(7):1332-7. doi: 10.4315/0362-028X.JFP-11-517. https://www.ncbi.nlm.nih.gov/pubmed/22980020
- Liu, L. Wei, F.X. Qu, Z.Y. Wang, S.Q. Chen, G. Gao, H. Zhang, H.Y. Shang, L. Yuan, X.H. Wang, Y.C. The antiadenovirus activities of cinnamaldehyde in vitro. Labmedicine, vol. 40, 2009, p.669-674 https://labmed.ascpjournals.org/content/40/11/669.abstract
- Al-Radha AS, Younes C, Diab BS, Jenkinson HF. Essential oils and zirconia dental implant materials. Int J Oral Maxillofac Implants. 2013 Nov-Dec;28(6):1497-505. doi: 10.11607/jomi.3142. https://www.ncbi.nlm.nih.gov/pubmed/24278917
- Pires RH., Montanari LB, Martins CH, Zaia JE, Almeida AM, Matsumoto MT, Mendes-Giannini MJ. Anticandidal efficacy of cinnamon oil against planktonic and biofilm cultures of Candida parapsilosis and Candida orthopsilosis. Mycopathologia. 2011 Dec;172(6):453-64. doi: 10.1007/s11046-011-9448-0. Epub 2011 Jul 15. https://www.ncbi.nlm.nih.gov/pubmed/21761153
- Nuryastuti T., van der Mei HC, Busscher HJ, Iravati S, Aman AT, Krom BP. Effect of cinnamon oil on icaA expression and biofilm formation by Staphylococcus epidermidis. Appl Environ Microbiol. 2009 Nov;75(21):6850-5. doi: 10.1128/AEM.00875-09. Epub 2009 Sep 11. https://www.ncbi.nlm.nih.gov/pubmed/19749058
- Oussalah M., Caillet S, Salmiéri S, Saucier L, Lacroix M. Antimicrobial effects of alginate-based films containing essential oils on Listeria monocytogenes and Salmonella typhimurium present in bologna and ham. J Food Prot. 2007 Apr;70(4):901-8. https://www.ncbi.nlm.nih.gov/pubmed/17477259
- Chiang LC., Cheng HY, Liu MC, Chiang W, Lin CC. Antiviral activity of eight commonly used medicinal plants in Taiwan. Am J Chin Med. 2003;31(6):897-905. https://www.ncbi.nlm.nih.gov/pubmed/14992542
- The antiadenovirus activities of cinnamaldehyde in vitro. p. 669.
- Gao H., Liu L, Qu ZY, Wei FX, Wang SQ, Chen G, Qin L, Jiang FY, Wang YC, Shang L, Gao CY. Anti-adenovirus activities of shikonin, a component of Chinese herbal medicine in vitro. Biol Pharm Bull. 2011;34(2):197-202. https://www.ncbi.nlm.nih.gov/pubmed/21415527
- Shang L., Qu Z, Sun L, Wang Y, Liu F, Wang S, Gao H, Jiang F. Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitro. J Pharm Pharmacol. 2011 May;63(5):688-94. doi: 10.1111/j.2042-7158.2011.01258.x. https://www.ncbi.nlm.nih.gov/pubmed/21492171
- Chiang LC., Ng LT, Cheng PW, Chiang W, Lin CC. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol. 2005 Oct;32(10):811-6. https://www.ncbi.nlm.nih.gov/pubmed/16173941
- Sharma M, Anderson SA, Schoop R, Hudson JB. Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract. Antiviral Res. 2009 Aug;83(2):165-70. doi: 10.1016/j.antiviral.2009.04.009. Epub 2009 May 3. https://www.ncbi.nlm.nih.gov/pubmed/19409931
- Pumerantz A, Muppidi K, Agnihotri S, Guerra C, Venketaraman V, Wang J, Betageri G. Preparation of liposomal vancomycin and intracellular killing of meticillin-resistant Staphylococcus aureus (MRSA). Int J Antimicrob Agents. 2011 Feb;37(2):140-4. doi: 10.1016/j.ijantimicag.2010.10.011. Epub 2010 Dec 3. https://www.ncbi.nlm.nih.gov/pubmed/21130608
- Alhariri M, Azghani A, Omri A. Liposomal antibiotics for the treatment of infectious diseases. Expert Opin Drug Deliv. 2013 Nov;10(11):1515-32. doi: 10.1517/17425247.2013.822860. Epub 2013 Jul 26. https://www.ncbi.nlm.nih.gov/pubmed/23886421
- Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 448.
- Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 165.
- Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 850.
- Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 511.
- Ecinacea. https://nccam.nih.gov/health/echinacea/ataglance.htm
- Frequency Specific Microcurrent Advanced Summary Protocols. https://www.frequencyspecific.com/faq.php#protocol
Image courtesy of Fanghong of Wikimedia Commons.