For people struggling with a recurring mycoplasma fatigue and joint pain
by Greg Lee
I once asked my mom for her secret recipe for barbeque steak. I would savor each bite as it filled my mouth with delicious flavor. I started salivating when I read her well-worn 3×5 card with the list of ingredients: steak, garlic (lots!), sugar, soy sauce, spring onions, rice wine, pepper, sesame seeds, and sesame oil. I felt like I discovered her hidden secret for flavor when I read: “poke holes in the meat with a fork and marinade overnight in the refrigerator.”
How can knowing about marinades help you to fight a persistent mycoplasma infection?
Mycoplasma infections can be found throughout into the body
Mycoplasmas are very small bacteria that can spread throughout the body and have been found especially in the lungs and heart1, central nervous system2, and the blood3. Mycoplasma infections have been linked to illnesses including: multiple sclerosis4, cancer5, chronic fatigue syndrome and fibromyalgia6, arthritis and hepatitus7. Patients report a wide range of symptoms including: respiratory tract infections, fever, chest pain, neurological problems, meningitis, encephalitis, and hemolytic anemia. These symptoms may persist despite antibiotic treatment because mycoplasma can develop drug resistance.
Antibiotic resistant mycoplasma infections are being found across the world
In multiple studies, macrolide or tetracycline antibiotic resistant mycoplasma have been found in North America8, Asia9,10, and Europe11. These germs can also form biofilms12, which can increase drug resistance up to five-thousand fold13. In addition to developing drug resistance, these germs can also hide inside cells14 which makes killing them much more challenging.
What else besides antibiotics can help you fight a persistent biofilm and intracellular mycoplasma infection?
Essential oils may help you fight a persistent mycoplasma infection
Fortunately, there are five essential oils that have anti-mycoplasma properties. These oils have been effective against multiple mycoplasma species. When these oils are formulated into a microparticle called a liposome, they may have a greater ability to penetrate deeper into biofilms and inside cells and kill mycoplasma in their hiding places. Fortunately, these essential oils have been used safely for decades for food preservation and in therapeutic treatments topically and internally.
Anti-Mycoplasma Essential Oil #1: Bergamot orange, Citrus Bergamia
The properties of this essential oil are cooling, refreshing, and astringent. It is recognized by the US Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS)15. However, bergamot essential oils that contain furanocoumarins are phototoxic potentially carcinogenic, and can lead to blistering if exposed to UV light or sunlight after being applied to the skin topically. Fortunately, there are furanocoumarin-free oils, labelled as bergamot essential oil (FCF) which are non-toxic16.
In one experiment, bergamot essential oil and its major components (limonene, linalyl acetate and linalool were tested against forty-two strains of Mycoplasma hominis, two strains of Mycoplasma fermentans, and one strain of Mycoplasma pneumoniae. All strains were inhibited at 0.5% (M. hominis and M. pneumonia) to 1% (M. fermentans) minimum inhibitory concentration (MIC) levels by bergamot essential oil. Linalyl acetate was highly effective against M. hominis and M. pneumonia with MIC levels of 0.015% and M. fermentan at MIC levels of 0.12%. Linalool had MIC values of 0.015% against M. pneumoniae, 0.06% MIC levels against M. fermentans, and 1% MIC levels against M. hominis. Limonene had MIC levels of 0.03% against M. pneumoniae, 1% against M. fermentans, and >4% against M. hominis17.
In other experiments, liposomal bergamot essential oil demonstrated anti-cancer properties18, the essential oil modulates intracellular calcium levels19, vaporized bergamot and orange essential oils remove methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus sp. (VRE) and their biofilms20, lavender and bergamot essential oil mixture helps to reduce anxiety and depression21, and bergamot essential oil has anti-inflammatory and anti-oxidant effects22. Another essential oil derived from tea tree also has anti-mycoplasma properties.
Anti-Mycoplasma Essential Oil #2: Tea tree, Melaleuca alternifolia
The properties of this essential oil are warming and fragrant. High doses, approximately a teaspoon to a half a teacup, of tea tree oil have resulted in ataxia, drowsiness, diarrhea, unconsciousness, and allergic reactions. Maximum topical dose is 15% when combined with other essential oils or carrier oils23.
In two studies, tea tree essential oil demonstrated anti-mycoplasma effects at very low concentrations. Against M. pneumoniae, MIC was 0.006% for the wild type and 0.003% against mutant strains24. In the second study, M. pneumoniae showed MIC values of 0.01%, M. fermentans, showed MIC values of 0.06%, and M. hominis was 0.12%25.
In other studies, tea tree has been effective against drug resistant MRSA, streptococcus, and candida26, reducing inflammation and stimulating pro-inflammatory cytokines27, and preventing influenza28. A combination of essential oils also demonstrated anti-mycoplasma properties in an animal study.
Anti-Mycoplasma Essential Oils #3: Peppermint, Mentha piperita combined with #4 Eucalyptus, species
The properties of peppermint essential oil are cooling, releases the exterior, and pungent. It is recognized by the US Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS)29. However, massive doses of peppermint essential oils, 4g/kg, produce neurotoxicity, hepatotoxicity, convulsions, and paralysis in animal studies30.
In one animal study, a commercial combination of peppermint and eucalyptus essential oils (Mentofin) helped to reduce the effects of a Mycoplasma gallisepticum and H9N2 infection in chickens by reducing mucus production and levels of intracellular infection³¹. In laboratory studies, peppermint essential oil combined with beta-lactam antibiotics reduces antibiotic resistance in drug resistant E. coli³², demonstrated moderate antibacterial activity against: Listeria monocytogenes, Clostridium perfringens, Bacillus cereus, Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis, and Staphylococcus epidermidis, Salmonella enterica, and Pseudomonas aeruginosa³³, inhibits candida and it’s biofilms³⁴., and peppermint combined with spearmint essential oil reduces chemotherapy-induced nausea and vomiting³⁵. Peppermint essential oil use is contraindicated in cases of cardiac fibrillation and in patients with a G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency.
Anti-Mycoplasma Essential oil #4 Eucalyptus, spp
The properties of eucalyptus essential oil are cooling, disperses wind, and releases the exterior. This essential oil is contraindicated in patients with inflammatory disease in their gastro-intestinal tract and bile ducts, and in cases with severe liver disease³⁶. Multiple cases of acute toxicity have been reported in adults and children after ingesting 5 ml to 75 ml with signs of central nervous system depression, abnormal respiration, and pinpoint pupils. Other symptoms of acute toxicity may include: stomach pain, vomiting, weak legs, cold sweats, headaches, and even death.
In laboratory and animal tests, eucalyptus essential oil demonstrated anti-bacterial activity against E. coli³⁷, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), multi-resistant Pseudomonas aeruginosa, ESBL-producing Escherichia coli and Klebsiella pneumoniae³⁸, Streptococcus mutans³⁹, Candida albicans⁴⁰, and reduces inflammation⁴¹. In addition to peppermint and eucalyptus, cinnamon oil was also effective at inhibiting mycoplasma.
Anti-Mycoplasma Essential Oil #5 Cinnamon bark
The properties of cinnamon essential oil are hot and sweet. It is recognized by the US Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS)⁴². In a lab study, cinnamon bark essential oil had antimicrobial activity against fifty clinical isolates of Mycoplasma hominis⁴³. In multiple lab studies, cinnamon bark essential oil has also been effective against drug persistent Lyme disease and it’s biofilms⁴⁴, drug-resistant Candida⁴⁵, Brucella abortus⁴⁶, and Aspergillus mold species and it’s toxins⁴⁷. In another lab study, liposomal cinnamon bark essential oil was effective at inhibiting drug resistant staphylococcus (MRSA) and it’s biofilms⁴⁸.
Caution: cinnamon oil has produced allergic dermatitis in some cases when placed on the skin. This oil may interfere with blood clotting. In one case, a boy drank 60 ml of cinnamon oil upon a dare and experienced symptoms of burning sensation in the mouth, chest and stomach, dizziness, double vision, nausea, vomiting and later collapsed. Microparticle essential oils may help enhance the fight against persistent mycoplasma symptoms.
Patients with mycoplasma report a significant reduction of chronic symptoms
After taking internal doses of microparticle “liposomal” essential oil mixtures containing one or more of the oils above, several patients have reported significant reduction in muscular and joint pain, headaches, insomnia, inflammation, fatigue, and mental fog, and confusion. In some cases, symptoms were aggravated due to a toxic die off Herxheimer reaction. Using essential oils in a careful, targeted strategy may help to reduce persistent mycoplasma symptoms.
The right essential oils can help you to fight off a persistent mycoplasma infection
Just like the right marinade, the proper anti-mycoplasma essential oils in a microparticle liposome may penetrate deeper into cells, under biofilms, and into the brain where mycoplasmas can cause troubling symptoms. These oils may help to significantly reduce the persistent pain, fatigue, and mental fog caused by these germs. Since these oils come with cautions and contraindications on their use, work with a Lyme literate essential oil practitioner to develop a safe and effective essential oil strategy for your condition.
>> Next step: Click here to watch my presentation, “Five Game-Changing Lyme Remedies” on the Best of Chronic Lyme Summit (free for first-time viewers).
P.S. Do you have experiences where treatment or remedies helped you eliminate or reduce inflammation and fatigue from a mycoplasma infection? Tell us about it.
1. Li CM, Gu L, Yin SJ, Yang R, Xie Y, Guo XZ, Fu YX, Cheng D. Age-specific Mycoplasma pneumoniae pneumonia-associated myocardial damage in children. J Int Med Res. 2013 Oct;41(5):1716-23. doi: 10.1177/0300060513497559. https://www.ncbi.nlm.nih.gov/pubmed/24026772
2. Schmucker RD, Ehret A, Marshall GS. Cerebellitis and Acute Obstructive Hydrocephalus Associated with Mycoplasma pneumoniae Infection. Pediatr Infect Dis J. 2013 Oct 22. https://www.ncbi.nlm.nih.gov/pubmed/24153008
3. Maggi RG, Compton SM, Trull CL, Mascarelli PE, Mozayeni BR, Breitschwerdt EB. Infection with hemotropic Mycoplasma species in patients with or without extensive arthropod or animal contact. J Clin Microbiol. 2013 Oct;51(10):3237-41. doi: 10.1128/JCM.01125-13. https://www.ncbi.nlm.nih.gov/pubmed/23863574
4. Libbey JE, Cusick MF, Fujinami RS. Role of Pathogens in Multiple Sclerosis. Int Rev Immunol. 2013 Nov 22. https://www.ncbi.nlm.nih.gov/pubmed/24266364
5. Erturhan SM, Bayrak O, Pehlivan S, Ozgul H, Seckiner I, Sever T, Karakök M. Can mycoplasma contribute to formation of prostate cancer? Int Urol Nephrol. 2013 Feb;45(1):33-8. doi: 10.1007/s11255-012-0299-5. https://www.ncbi.nlm.nih.gov/pubmed/23001641
6. Endresen GK. Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes. Rheumatol Int. 2003 Sep;23(5):211-5. https://www.ncbi.nlm.nih.gov/pubmed/12879275
7. Berghoff W. Chronic Lyme Disease and Co-infections: Differential Diagnosis. Open Neurol J. 2012;6:158-78. doi: 10.2174/1874205X01206010158. https://www.ncbi.nlm.nih.gov/pubmed/23400696
8. Eshaghi A, Memari N, Tang P, Olsha R, Farrell DJ, Low DE, Gubbay JB, Patel SN. Macrolide-resistant Mycoplasma pneumoniae in humans, Ontario, Canada, 2010-2011. Emerg Infect Dis. 2013;19(9). doi: 10.3201/eid1909.121466. https://www.ncbi.nlm.nih.gov/pubmed/23968896
9. Matsuda K, Narita M, Sera N, Maeda E, Yoshitomi H, Ohya H, Araki Y, Kakuma T, Fukuoh A, Matsumoto K. Gene and cytokine profile analysis of macrolide-resistant Mycoplasma pneumoniae infection in Fukuoka, Japan. BMC Infect Dis. 2013 Dec 16;13(1):591. https://www.ncbi.nlm.nih.gov/pubmed/24330612
10. Ye G, Jiang Z, Wang M, Huang J, Jin G, Lu S. The Resistance Analysis of Ureaplasma urealyticum and Mycoplasma hominis in Female Reproductive Tract Specimens. Cell Biochem Biophys. 2013 Jun 9. https://www.ncbi.nlm.nih.gov/pubmed/23749559
11. Dumke R, Lück C, Jacobs E. Low rate of macrolide resistance in Mycoplasma pneumoniae strains in Germany between 2009 and 2012. Antimicrob Agents Chemother. 2013 Jul;57(7):3460. doi: 10.1128/AAC.00706-13. https://www.ncbi.nlm.nih.gov/pubmed/23650170
12. Simmons WL, Daubenspeck JM, Osborne JD, Balish MF, Waites KB, Dybvig K. Type 1 and type 2 strains of Mycoplasma pneumoniae form different biofilms. Microbiology. 2013 Apr;159(Pt 4):737-47. doi: 10.1099/mic.0.064782-0. https://www.ncbi.nlm.nih.gov/pubmed/23412845
13. Del Pozo JL, Rouse MS, Patel R. Bioelectric effect and bacterial biofilms. A systematic review. Int J Artif Organs. 2008 Sep;31(9):786-95. https://www.ncbi.nlm.nih.gov/pubmed/18924090
14. Hopfe M, Deenen R, Degrandi D, Köhrer K, Henrich B. Host cell responses to persistent mycoplasmas–different stages in infection of HeLa cells with Mycoplasma hominis. PLoS One. 2013;8(1):e54219. doi: 10.1371/journal.pone.0054219. https://www.ncbi.nlm.nih.gov/pubmed/23326599
15. US Food and Drug Adminstration CFR Code of Federal Regulations Title 21, Vol. 3. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.20
16. Tisserand, R. and Young. R. Essential Oil Safety: A Guide for Healthcare Professionals. Second Ed. London, Churchill Livingstone, pp. 211-213. https://www.amazon.com/Essential-Oil-Safety-Health-Professionals/dp/0443062412
17. Furneri PM, Mondello L, Mandalari G, Paolino D, Dugo P, Garozzo A, Bisignano G. In vitro antimycoplasmal activity of Citrus bergamia essential oil and its major components. Eur J Med Chem. 2012 Jun;52:66-9. doi: 10.1016/j.ejmech.2012.03.005. https://www.ncbi.nlm.nih.gov/pubmed/22465092
18. Celia C, Trapasso E, Locatelli M, Navarra M, Ventura CA, Wolfram J, Carafa M, Morittu VM, Britti D, Di Marzio L, Paolino D. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids Surf B Biointerfaces. 2013 Dec 1;112:548-53. doi: 10.1016/j.colsurfb.2013.09.017. https://www.ncbi.nlm.nih.gov/pubmed/24099646
19. You JH, Kang P, Min SS, Seol GH. Bergamot essential oil differentially modulates intracellular Ca2+ levels in vascular endothelial and smooth muscle cells: a new finding seen with fura-2. J Cardiovasc Pharmacol. 2013 Apr;61(4):324-8. doi: 10.1097/FJC.0b013e3182834681. https://www.ncbi.nlm.nih.gov/pubmed/23288200
20. Laird K, Armitage D, Phillips C. Reduction of surface contamination and biofilms of Enterococcus sp. and Staphylococcus aureus using a citrus-based vapour. J Hosp Infect. 2012 Jan;80(1):61-6. doi: 10.1016/j.jhin.2011.04.008. https://www.ncbi.nlm.nih.gov/pubmed/22153952
21. Hongratanaworakit T. Aroma-therapeutic effects of massage blended essential oils on humans. Nat Prod Commun. 2011 Aug;6(8):1199-204. https://www.ncbi.nlm.nih.gov/pubmed/21922934
22. Trombetta D, Cimino F, Cristani M, Mandalari G, Saija A, Ginestra G, Speciale A, Chirafisi J, Bisignano G, Waldron K, Narbad A, Faulds CB. J Agric Food Chem. 2010 Jul 28;58(14):8430-6. doi: 10.1021/jf1008605. https://www.ncbi.nlm.nih.gov/pubmed/20578719
23. Tisserand, R. and Young. R. Essential Oil Safety. pp. 440-445.
24. Harkenthal M, Layh-Schmitt G, Reichling J. Effect of Australian tea tree oil on the viability of the wall-less bacterium Mycoplasma pneumoniae. Pharmazie. 2000 May;55(5):380-4. https://www.ncbi.nlm.nih.gov/pubmed/11828621
25. Furneri PM, Paolino D, Saija A, Marino A, Bisignano G. In vitro antimycoplasmal activity of Melaleuca alternifolia essential oil. J Antimicrob Chemother. 2006 Sep;58(3):706-7. Epub 2006 Jun 20. https://jac.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=16787951
26. Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PA, Wiltfang J, Fickenscher H, Sherry E. The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Craniomaxillofac Surg. 2009 Oct;37(7):392-7. doi: 10.1016/j.jcms.2009.03.017. https://www.ncbi.nlm.nih.gov/pubmed/19473851
27. Taga I, Lan CQ, Altosaar I. Plant essential oils and mastitis disease: their potential inhibitory effects on pro-inflammatory cytokine production in response to bacteria related inflammation. Nat Prod Commun. 2012 May;7(5):675-82. https://www.ncbi.nlm.nih.gov/pubmed/22799106
28. Li X, Duan S, Chu C, Xu J, Zeng G, Lam AK, Zhou J, Yin Y, Fang D, Reynolds MJ, Gu H, Jiang L. Melaleuca alternifolia concentrate inhibits in vitro entry of influenza virus into host cells. Molecules. 2013 Aug 9;18(8):9550-66. doi: 10.3390/molecules18089550. https://www.ncbi.nlm.nih.gov/pubmed/23966077
29. US Food and Drug Adminstration CFR Code of Federal Regulations Title 21, Vol. 3.
30. Tisserand, R. and Young. R. Essential Oil Safety, 2nd Ed. pp. 387-390.
31. Barbour, E., El-Hakim, R., Kaadi, M., Shaib, H., Gerges, D., Nehme, P. Evaluation of the Histopathology of the Respiratory System in Essential Oil-Treated Broilers Following a Challenge With Mycoplasma gallisepticum and/or H9N2 Influenza Virus. https://www.jarvm.com/articles/
32. Yap PS, Lim SH, Hu CP, Yiap BC. Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria. Phytomedicine. 2013 Jun 15;20(8-9):710-3. doi: 10.1016/j.phymed.2013.02.013. https://www.ncbi.nlm.nih.gov/
33. Silva N, Alves S, Gonçalves A, Amaral JS, Poeta P. Antimicrobial activity of essential oils from mediterranean aromatic plants against several foodborne and spoilage bacteria. Food Sci Technol Int. 2013 Dec;19(6):503-10. doi: 10.1177/1082013212442198. https://www.ncbi.nlm.nih.gov/
34. Saharkhiz MJ, Motamedi M, Zomorodian K, Pakshir K, Miri R, Hemyari K. Chemical Composition, Antifungal and Antibiofilm Activities of the Essential Oil of Mentha piperita L. ISRN Pharm. 2012;2012:718645. doi: 10.5402/2012/718645. https://www.ncbi.nlm.nih.gov/
35. Tayarani-Najaran Z, Talasaz-Firoozi E, Nasiri R, Jalali N, Hassanzadeh M. Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting. Ecancermedicalscience. 2013;7:290. doi: 10.3332/ecancer.2013.290. https://www.ncbi.nlm.nih.gov/
36. Tisserand, R. and Young. R. Essential Oil Safety, 2nd Ed. pp. 272-275.
37. Bachir RG, Benali M. Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. Asian Pac J Trop Biomed. 2012 Sep;2(9):739-42. doi: 10.1016/S2221-1691(12)60220-2. https://www.ncbi.nlm.nih.gov/
38. Warnke PH, Lott AJ, Sherry E, Wiltfang J, Podschun R. The ongoing battle against multi-resistant strains: in-vitro inhibition of hospital-acquired MRSA, VRE, Pseudomonas, ESBL E. coli and Klebsiella species in the presence of plant-derived antiseptic oils. J Craniomaxillofac Surg. 2013 Jun;41(4):321-6. doi: 10.1016/j.jcms.2012.10.012. https://www.ncbi.nlm.nih.gov/
39. Chaudhari LK, Jawale BA, Sharma S, Sharma H, Kumar CD, Kulkarni PA. Antimicrobial activity of commercially available essential oils against Streptococcus mutans. J Contemp Dent Pract. 2012 Jan 1;13(1):71-4. https://www.ncbi.nlm.nih.gov/
40. Carvalhinho S, Costa AM, Coelho AC, Martins E, Sampaio A. Susceptibilities of Candida albicans mouth isolates to antifungal agents, essentials oils and mouth rinses. Mycopathologia. 2012 Jul;174(1):69-76. doi: 10.1007/s11046-012-9520-4. https://www.ncbi.nlm.nih.gov/
41. Gbenou JD, Ahounou JF, Akakpo HB, Laleye A, Yayi E, Gbaguidi F, Baba-Moussa L, Darboux R, Dansou P, Moudachirou M, Kotchoni SO. Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats. Mol Biol Rep. 2013 Feb;40(2):1127-34. doi: 10.1007/s11033-012-2155-1. https://www.ncbi.nlm.nih.gov/
42. US Food and Drug Adminstration CFR Code of Federal Regulations Title 21, Vol. 3.https://www.accessdata.fda.gov/
43. “In Vitro Antimicrobial Activities of Cinnamon Bark Oil, Anethole, Carvacrol, Eugenol and Guaiazulene against Mycoplasma Hominis Clinical Isolates. – PubMed – NCBI.” Accessed January 7, 2018.https://www.ncbi.nlm.nih.gov/
44. Feng, Jie, Shuo Zhang, Wanliang Shi, Nevena Zubcevik, Judith Miklossy, and Ying
Zhang. “Selective Essential Oils from Spice or Culinary Herbs Have High Activity against
Stationary Phase and Biofilm Borrelia Burgdorferi.” Frontiers in Medicine 4 (2017).
45. Soares, I. H., É S. Loreto, L. Rossato, D. N. Mario, T. P. Venturini, F. Baldissera, J. M. Santurio, and S. H. Alves. “In Vitro Activity of Essential Oils Extracted from Condiments against Fluconazole-Resistant and -Sensitive Candida Glabrata.” Journal De Mycologie Médicale 25, no. 3 (September 2015): 213-17.
46. Al-Mariri A, Saour G, Hamou R. In vitro antibacterial effects of five volatile oil extracts against intramacrophage Brucella abortus 544. Iran J Med Sci. 2012 Jun;37(2):119-25. https://www.ncbi.nlm.nih.gov/
47. Lokman Alpsoy. Inhibitory Effect of Essential Oil on Aflatoxin Activity. African Journal of Biotechnology Vol. 9(17), pp. 2474-2481, 19 April, 2010 www.ajol.info/index.php/ajb/
48. Cui, Haiying, Wei Li, Changzhu Li, Saritporn Vittayapadung, and Lin Lin. “Liposome Containing Cinnamon Oil with Antibacterial Activity against Methicillin-Resistant