For people with Lyme disease, co-infections, and biofilms who have recurring bladder discomfort, frequent urination, and anxiety about going to the bathroom
by Greg Lee
I grew up with lots of guinea pigs. Once, a tiny baby piglet crawled under a big heavy sofa. I tried coaxing him out by calling his name, dangling a long piece of grass in front of him, and bringing one of the other piglets nearby. No matter what I did, he stayed under the sofa. What finally got him out was taking a plastic bag with lettuce inside and making a crinkling sound. All the other guinea pigs squeaked loudly thinking they were about to get fed. He ran out lightning quick to see what the fuss was about.
How is a guinea pig hiding under a sofa like a person with recurring discomfort and inflammation in their bladder?
Similar to a hiding guinea pig, inflammation and discomfort can be very difficult to pull out of the bladder
People with recurring urinary tract infections (UTIs) can have symptoms of fatigue, chronic pubic pain, loss of appetite, malaise, pain during urination, copious amounts of urine, urinary incontinence, painful intercourse, urinary urgency, burning sensations in the lower pelvic area with stabbing-like pain, blood in the urine, depression, anxiety, and constipation1. Underlying reasons for recurring bladder discomfort and pain remain elusive. Urine cultures have detected E. Coli2 in some UTI patients. Chlamydia pneumoniae and Lyme disease are also suspected infections which can cause painful bladder symptoms people with interstitial cystitis3. Some patients have struggled for years with persistent bladder discomfort.
Carla’s changed her diet drastically to limit bladder discomfort
Carla avoided foods that triggered symptoms at all costs. When ever she went out to eat, she would avoid eating tomatoes, spicy foods, citrus, sweetened and processed foods. She never drank coffee, sodas, or alcohol. Her friends made fun of her for asking the waiter about the ingredients in her meal. They eventually stopped inviting her out to social events. She would spend hours and hours searching online for the latest research and treatments for reducing bladder discomfort. She read about the inflammatory compounds that get elevated in human and animal studies on bladder pain and interstitial cystitis.
In one study, bladder pain patients had elevated TGF-beta, decorin (a proteoglycan of chondroitin/dermatan sulfate), fibronectin and hyaluronic acid4. In animal interstitial cystitis experiments, IL-1α, IL-1β, and TNF-α were elevated5. Medications have been effective in a limited number of cases.
Only two medications are approved for treating chronic bladder pain
The first is oral pentosan polysulfate. The other treatment is to place dimethyl sulfoxide into the bladder through a catheter. These treatments have been effective in approximately 30 – 60% of patients. It can have unfavorable side effects, including nausea, diarrhea, gastric distress, and hair loss. Other treatments may include procedures, such as hydrodistention, and oral pharmaceutical drugs, such as antihistamines, tricyclic antidepressants, and immune modulators6. There are multiple factors behind why treatment has a low success rate.
Underlying bladder infections can be hidden which makes detection difficult
One theory for the difficulty in detecting underlying infections in recurring bladder pain is biofillms7. Biofilms are basically a slime that infections can hide under which reduces the likelihood of detection. Biofilms can harbor multiple infections8 which may lead to increased inflammation and pain in the bladder wall. Another reason is drug resistance. E. Coli that are antibiotic resistant9 have been found in urine culture tests. Biofilms can also increase drug resistance as high as one-thousand fold10. Chronic bladder pain patients have also tested positive for Lyme disease.
Lyme disease is found in patients with chronic bladder symptoms
Many patients with chronic bladder pain have also tested positive for Lyme disease and tick co-infections like Bartonella at a medical practice specializing in interstitial cystitis. Also, rare and unusual bacterial and fungal infections have been found by PCR testing in patients after flushing the bladder with an anti-biofilm medication called Ethylenediaminetetraacetic acid (EDTA) via catheter. Broad spectrum antimicrobial remedies delivered via catheter have also been much more effective at relieving bladder discomfort when combined with EDTA11. In another study, catheter delivered hydrocortisone and heparin, along with oral bladder sedatives and systemic steroids provided significant relief12.
In addition to catheter delivered medications, what else can help you to relieve painful bladder discomfort?
Here are five strategies for relieving chronic bladder pain
There are five strategies that have helped patients to reduce or eliminate persistent bladder discomfort.
● Reduce toxicity and inflammation which aggravate the bladder lining
● Cut through biofilms and kill pathogens
● Heal damage to the bladder
● Improve diet to reduce / eliminate trigger foods
● Get treatments for reducing pain and discomfort
Reducing Bladder Pain Strategy #1: Reduce toxicity and inflammation
Infections in the bladder can trigger the production of inflammation which can lead to pain and discomfort. Neutralizing these inflammatory compounds can help to reduce the irritation in the bladder. There are several herbs and an essential oil that reduce the inflammatory compounds which can aggravate bladder discomfort. A highly effective delivery method is to micronized the herbs into small particles called liposomes. Liposomes are remedies that are wrapped in a layer of fat called a lipid in order to increase their penetration into the bladder. In addition to liposomes, cinnamon essential oil is diluted with a carrier oil at a very low concentration and applied topically to reduce inflammation.
Salvia root, Chinese name: Dan Shen, has been used for over 1900 years. Traditionally, salvia has been used to replenish the blood, move blood stagnation, and reduce inflammation. Modern research in China reports that this herb improves microcirculation of the blood, protects the liver against fibrosis and cirrhosis, and aids in the healing of bone fractures13. It has been found to inhibit IL-1α, TNF-α14, TGF-β115, and IL-1β in animal studies16.
Raw ginger, Chinese name: Sheng Jiang, is used in a wide variety of herbal formulas for treating toxicity, burns, nausea, coldness in the stomach17, lung phlegm18, pain19, alopecia20, rhematoid arthritis, and inflammation21. This herb inhibits IL-1α and TNF-α in a human study22. Gingerol, one of the main compounds in raw ginger, inhibits TGF-β in a lab study23.
Cassia leaf essential oil and the compound cinnamaldehyde inhibits TNF-α and IL-1β in a lab study24. In addition to herbs and supplements, Frequency Specific Microcurrent can help to neutralize toxins and inflammation.
Frequency Specific Microcurrent uses low level electrical currents to reduce pain (20), neutralize toxins (12), reduce biofilms (28) and lower inflammation (284, 82) which are paired with a second current for targeting the urinary system (48), ureter (60), urinary bladder (37) and the bladder sphincter (178)25. Carla noticed significant relief immediately after her microcurrent sessions. In addition to removing toxins and inflammation, cutting through biofilms to get to infections is next.
Reducing Bladder Pain Strategy #2: Disrupt biofilms and kill hidden bladder infections
Biofilms are like a resealable plastic bag. Germs can go in, out, and back into hiding again. If you dissolve the plastic, you can get to the pathogens. Essential oils have compounds called phenols which are solvents that cut through biofilms. Essential oils can be combined in a 1:1 ratio with a carrier oil. This mixture can be used topically to deliver oils into the biofilms and germs in the bladder and urinary tract. Fortunately, liposomal essential oils can penetrate deeper into biofilms, disrupt biofilm formation, and kill the underlying pathogens. Carla said that her liposomal essential oil remedy tasted like a combination of furniture polish and Christmas.
Cinnamon bark oil and its components, cinnamaldehyde and eugenol, inhibit E. Coli biofilm formation in a lab study26. Cinnamon oil is a broad spectrum anti-microbial which has been effective at inhibiting biofilms and the following pathogens from Acinetobacter baumannii27, Candida parapsilosis28, and Staphylococcus epidermidis29. Due to it’s strong nature, low dose cinnamon oils are safest for preventing tissues irritation.
Clary sage, juniper, lemon and marjoram essential oils inhibited biofilm formation around mixed cultures of E. Coli, and other pathogens30.
Tea tree and melissa essential oils inhibited E. Coli and Staph aureus biofilm formation in a lab study31. In multiple human, lab and animal studies, tea tree is effective at inhibiting pathogens and their biofilms including Candida32, Staphylococcus aureus33, Listeria monocytogenes34, and oral biofilms35.
Rose, geranium, lavender, and rosemary essential oils were effective at inhibiting E. coli communication signals for biofilm production called Quorum Sensing36.
Eugenol from clove essential oil and terpinen from tea tree essential oil were highly effective at inhibiting Proteus mirabilis biofilms in a catheter study37. Clove oil disrupts how Pseudomonas aeruginosa and Aeromonas hydrophila communicate to form biofilms in one lab study38. Clove also inhibited biofilm formation and these pathogens in lab studies on Streptococcus pneumoniae39, Enterococcus faecalis40, and Candida albicans41. Due to it’s strong nature, low dose clove oils are safest for preventing bladder irritation.
Reducing Bladder Pain Strategy #3: Heal damage to the bladder
Multiple pathogens in the bladder can trigger the release of the inflammatory compounds. These compounds can irritate and damage the lining of the bladder. Herbs and their constituent compounds have been helpful for preventing or reducing bladder irritation. These herbs are processed into a liposomal form to increase their penetration in the the bladder.
Berberine is a compound found in coptis rhizome, Chinese name: Huang Lian and phellodendron, Chinese name: Huang Bai. In a rat study, berberine completely prevented cyclophosphamide induced bladder edema and hemorrhage. It also dramatically increased nitric oxide (NO) metabolites in urine and plasma42. Nitric oxide is an antimicrobial compound produced by the immune system to kill infections.
Astragalus extract, Chinese name: Huang Qi protected mice from urinary bladder carcinoma and lowered interleukin-2 (IL-2) and interferon-gamma (IFN-γ)43.
Maitake mushroom, Chinese name: Zhu Ling reduced recurrence of bladder cancer in a rat and human study. Fifteen out of twenty two patients had no recurrence of bladder cancer44.
Magnolia bark, Chinese name: Hou Po inhibited bladder cancer cells and inflammatory compounds in a lab study45.
Reducing Bladder Pain Strategy #4: Improve diet to reduce bladder symptoms
Reduce or avoid foods that increase bladder discomfort: items containing caffeine, citrus juices, tomato products, items containing vinegar, hot peppers, alcohol46, citrus fruits, tomatoes, vitamin C, artificial sweeteners, coffee, tea, carbonated and alcoholic beverages, and spicy foods. Increase supplements that improve symptoms: calcium glycerophosphate and sodium bicarbonate47.
A combination of parsley and garlic, L-arginine, probiotics, and cranberry tablets reduced bladder pain and discomfort in patients diagnosed with drug resistant E. Coli in their urine test48.
Reducing Bladder Pain Strategy #5: Get treatments to reduce inflammation and discomfort
Visceral manipulation is an osteopathic manual manipulation technique which can help release inflammation and reduce pain in tissues and organs49. When Carla received visceral treatment, she could feel heat and tenderness being released quickly out of her bladder area. Her discomfort would reduce from an 8 to a 3 out of 10.
Acupuncture uses points that help to release heat and discomfort out of the bladder50. A combination of topical essential oils, liposomal herbs and remedies, and treatments can help to significantly reduce the bladder inflammation, discomfort, and symptoms of infection.
Remedies, treatments, and a healthy diet can help to reduce symptoms of bladder discomfort caused by infections hidden under biofilms
Just like finding the right lure to coax a baby guinea pig out of its hiding place, a combination of liposomal herbs, essential oils, supplements, Frequency Specific Microcurrent, acupuncture, visceral manipulation and dietary modifications helped Carla to pull the pain and discomfort out of her bladder. Since some of these remedies and treatments require specialized training, work with a Lyme literate Chinese medicine practitioner to develop a proper, safe, and effective strategy for your condition.
>> Next step: Click here to take our Stealthy Co-infection Quiz to see which tick infections may be causing your symptoms.
P.S. Do you have experiences where treatments or remedies improved your bladder pain, urgency, and anxiety? Tell us about it.
1. Mansour, Anthony, Essa Hariri, Samar Shelh, Ralph Irani, and Mohamad Mroueh. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.” Case Reports in Medicine 2014 (2014). doi:10.1155/2014/698758. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283390/
2. Mansour, A., et. Al. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.”
3. Cohan, W. The Better Bladder Book: A Holistic Approach to Healing Interstitial Cystitis & Chronic Pelvic Pain. Alameda: Hunter House, Inc. https://www.amazon.com/The-Better-Bladder-Book-Interstitial-ebook/dp/B004R9PZNW
4. Lucon, Marcos, João Roberto Martins, Katia Ramos Moreira Leite, Roberto Soler, Helena B. Nader, Miguel Srougi, and Homero Bruschini. “Evaluation of the Metabolism of Glycosaminoglycans in Patients with Interstitial Cystis.” International Braz J Urol: Official Journal of the Brazilian Society of Urology 40, no. 1 (February 2014): 72–79. https://www.ncbi.nlm.nih.gov/pubmed/24642152
5. Tambaro, Simone, Maria Antonietta Casu, Andrea Mastinu, and Paolo Lazzari. “Evaluation of Selective Cannabinoid CB(1) and CB(2) Receptor Agonists in a Mouse Model of Lipopolysaccharide-Induced Interstitial Cystitis.” European Journal of Pharmacology 729 (April 15, 2014): 67–74. doi:10.1016/j.ejphar.2014.02.013. https://www.ncbi.nlm.nih.gov/pubmed/24561047
6. Fiehn, Oliver, and Jayoung Kim. “Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis.” International Neurourology Journal 18, no. 3 (September 2014): 106–14. doi:10.5213/inj.2014.18.3.106. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180160/
7. Graziottin, A., P. P. Zanello, and G. D’Errico. “[Recurrent cystitis and vaginitis: role of biofilms and persister cells. From pathophysiology to new therapeutic strategies].” Minerva Ginecologica 66, no. 5 (October 2014): 497–512. https://www.ncbi.nlm.nih.gov/pubmed/25245998
8. Burmølle, Mette, Trine Rolighed Thomsen, Mustafa Fazli, Irene Dige, Lise Christensen, Preben Homøe, Michael Tvede, et al. “Biofilms in Chronic Infections – a Matter of Opportunity – Monospecies Biofilms in Multispecies Infections.” FEMS Immunology and Medical Microbiology 59, no. 3 (August 2010): 324–36. doi:10.1111/j.1574-695X.2010.00714.x. https://www.ncbi.nlm.nih.gov/pubmed/20602635
9. Mansour, A., et. Al. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.”
10. Sriramulu, Dinesh. “Evolution and Impact of Bacterial Drug Resistance in the Context of Cystic Fibrosis Disease and Nosocomial Settings.” Microbiology Insights 6 (April 14, 2013): 29–36. doi:10.4137/MBI.S10792. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987750/
11. Private conversation with R. Kriz. March 15, 2015.
12. Taneja, Rajesh, and Kailash K. Jawade. “A Rational Combination of Intravesical and
Systemic Agents for the Treatment of Interstitial Cystitis.” Scandinavian Journal of Urology and Nephrology 41, no. 6 (2007): 511–15. doi:10.1080/00365590701435918. https://www.ncbi.nlm.nih.gov/pubmed/17853025
13. Dharmananda, S. Salvia and the History of Microcirculation Research in China. https://www.itmonline.org/arts/salvia.htm
14. Zhang, Ying, Yuanyuan Zhang, Yun Xie, Yonggang Gao, Juanjuan Ma, Jie Yuan, Juan Li, et al. “Multitargeted Inhibition of Hepatic Fibrosis in Chronic Iron-Overloaded Mice by Salvia Miltiorrhiza.” Journal of Ethnopharmacology 148, no. 2 (July 9, 2013): 671–81. doi:10.1016/j.jep.2013.05.028. https://www.ncbi.nlm.nih.gov/pubmed/23707206
15. Lee, Hak Sung, Woo-Chan Son, Jae-Eun Ryu, Bon Am Koo, and Yeong Shik Kim. “Standardized Salvia Miltiorrhiza Extract Suppresses Hepatic Stellate Cell Activation and Attenuates Steatohepatitis Induced by a Methionine-Choline Deficient Diet in Mice.” Molecules (Basel, Switzerland) 19, no. 6 (2014): 8189–8211. doi:10.3390/molecules19068189. https://www.ncbi.nlm.nih.gov/pubmed/24941342
16. Xiping, Zhang, Pan Yan, Huang Xinmei, Feng Guanghua, Ma Meili, Ni Jie, and Zhang Fangjie. “Effects of Dexamethasone and Salvia Miltiorrhizae on the Small Intestine and Immune Organs of Rats with Severe Acute Pancreatitis.” Inflammation 33, no. 4 (August 2010): 259–66. doi:10.1007/s10753-010-9180-9. https://www.ncbi.nlm.nih.gov/pubmed/20127399
17. Dharmananda, S. Countering the Side Effects of Modern Medical Therapies With Chinese Herbs. https://www.itmonline.org/arts/sidefx.htm
18. Dharmananda, S. A Study Guide to Phlegm-Resolving Herbs. https://www.itmonline.org/arts/phlegm.htm
19. Dharmananda, S. Safety Issues Affecting Chinese Herbs: The Case of Ma-huang. https://www.itmonline.org/arts/mahuang.htm
20. Dharmananda, S. Treatment of Alopecia With Chinese Herbs. https://www.itmonline.org/arts/alopecia.htm
21. Dharmananda, An Analysis of Chinese Herb Prescriptions for Rheumatoid Arthritis. https://www.itmonline.org/arts/arthritis.htm
22. Percival, Susan S., John P. Vanden Heuvel, Carmelo J. Nieves, Cindy Montero, Andrew J. Migliaccio, and Joanna Meadors. “Bioavailability of Herbs and Spices in Humans as Determined by Ex Vivo Inflammatory Suppression and DNA Strand Breaks.” Journal of the American College of Nutrition 31, no. 4 (August 2012): 288–94. https://www.ncbi.nlm.nih.gov/pubmed/23378457
23. Kamato, Danielle, Hossein Babaahmadi Rezaei, Robel Getachew, Lyna Thach, Daniel Guidone, Narin Osman, Basil Roufogalis, et al. “(S)--Gingerol Inhibits TGF-Β-Stimulated Biglycan Synthesis but Not Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells.” The Journal of Pharmacy and Pharmacology 65, no. 7 (July 2013): 1026–36. doi:10.1111/jphp.12060. https://www.ncbi.nlm.nih.gov/pubmed/23738730
24. Pannee, Chinjarernpan, Itthipanichpong Chandhanee, and Limpanasithikul Wacharee. “Antiinflammatory Effects of Essential Oil from the Leaves of Cinnamomum Cassia and Cinnamaldehyde on Lipopolysaccharide-Stimulated J774A.1 Cells.” Journal of Advanced Pharmaceutical Technology & Research 5, no. 4 (October 2014): 164–70. doi:10.4103/2231-4040.143034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215479/
25. McMakin C. Frequency Specific Microcurrent in Pain Management. Edinburgh: Churchill Livingstone/Elsevier; 2011.
26. Szabó, Mira Agnes, Gábor Zoltán Varga, Judit Hohmann, Zsuzsanna Schelz, Erno
Szegedi, Leonard Amaral, and József Molnár. “Inhibition of Quorum-Sensing Signals by Essential Oils.” Phytotherapy Research: PTR 24, no. 5 (May 2010): 782–86. doi:10.1002/ptr.3010. https://www.ncbi.nlm.nih.gov/pubmed/25500277
27. Sienkiewicz, Monika, Anna Głowacka, Edward Kowalczyk, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, and Monika Łysakowska. “The Biological Activities of Cinnamon, Geranium and Lavender Essential Oils.” Molecules (Basel, Switzerland) 19, no. 12 (2014): 20929–40. doi:10.3390/molecules191220929. https://www.ncbi.nlm.nih.gov/pubmed/25514231
28. Pires, Regina Helena, Lilian Bueno Montanari, Carlos Henrique G. Martins, José Eduardo Zaia, Ana Marisa Fusco Almeida, Marcelo T. Matsumoto, and Maria José S. Mendes-Giannini. “Anticandidal Efficacy of Cinnamon Oil against Planktonic and Biofilm Cultures of Candida Parapsilosis and Candida Orthopsilosis.” Mycopathologia 172, no. 6 (December 2011): 453–64. doi:10.1007/s11046-011-9448-0. https://www.ncbi.nlm.nih.gov/pubmed/21761153
29. Nuryastuti, Titik, Henny C. van der Mei, Henk J. Busscher, Susi Iravati, Abu T. Aman, and Bastiaan P. Krom. “Effect of Cinnamon Oil on icaA Expression and Biofilm Formation by Staphylococcus Epidermidis.” Applied and Environmental Microbiology 75, no. 21 (November 2009): 6850–55. doi:10.1128/AEM.00875-09. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772433/
30. Kerekes, E.-B., É Deák, M. Takó, R. Tserennadmid, T. Petkovits, C. Vágvölgyi, and J. Krisch. “Anti-Biofilm Forming and Anti-Quorum Sensing Activity of Selected Essential Oils and Their Main Components on Food-Related Micro-Organisms.” Journal of Applied Microbiology 115, no. 4 (October 2013): 933–42. doi:10.1111/jam.12289. https://www.ncbi.nlm.nih.gov/pubmed/23789847
31. Budzyńska, Aleksandra, Marzena Wieckowska-Szakiel, Beata Sadowska, Danuta Kalemba, and Barbara Rózalska. “Antibiofilm Activity of Selected Plant Essential Oils and Their Major Components.” Polish Journal of Microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists 60, no. 1 (2011): 35–41. https://www.ncbi.nlm.nih.gov/pubmed/21630572
32. De Campos Rasteiro, Vanessa Maria, Anna Carolina Borges Pereira da Costa, Cássia Fernandes Araújo, Patrícia Pimentel de Barros, Rodnei Dennis Rossoni, Ana Lia Anbinder, Antonio Olavo Cardoso Jorge, and Juliana Campos Junqueira. “Essential Oil of Melaleuca Alternifolia for the Treatment of Oral Candidiasis Induced in an Immunosuppressed Mouse Model.” BMC Complementary and Alternative Medicine 14 (2014): 489. doi:10.1186/1472-6882-14-489. https://www.ncbi.nlm.nih.gov/pubmed/25510285
33. Brady, A. J., T. B. Farnan, J. G. Toner, D. F. Gilpin, and M. M. Tunney. “Treatment of a Cochlear Implant Biofilm Infection: A Potential Role for Alternative Antimicrobial Agents.” The Journal of Laryngology and Otology 124, no. 7 (July 2010): 729–38. doi:10.1017/S0022215110000319. https://www.ncbi.nlm.nih.gov/pubmed/20214837
34. Sandasi, M., C. M. Leonard, and A. M. Viljoen. “The in Vitro Antibiofilm Activity of Selected Culinary Herbs and Medicinal Plants against Listeria Monocytogenes.” Letters in Applied Microbiology 50, no. 1 (January 2010): 30–35. doi:10.1111/j.1472-765X.2009.02747.x. https://www.ncbi.nlm.nih.gov/pubmed/19874481
35. Santamaria, Milton, Klodyne Dayana Petermann, Silvia Amélia Scudeler Vedovello, Viviane Degan, Adriana Lucato, and Cristina Maria Franzini. “Antimicrobial Effect of Melaleuca Alternifolia Dental Gel in Orthodontic Patients.” American Journal of Orthodontics and Dentofacial Orthopedics: Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics 145, no. 2 (February 2014): 198–202. doi:10.1016/j.ajodo.2013.10.015. https://www.ncbi.nlm.nih.gov/pubmed/24485734
36. Szabó, Mira Agnes, Gábor Zoltán Varga, Judit Hohmann, Zsuzsanna Schelz, Erno Szegedi, Leonard Amaral, and József Molnár. “Inhibition of Quorum-Sensing Signals by Essential Oils.” Phytotherapy Research: PTR 24, no. 5 (May 2010): 782–86. doi:10.1002/ptr.3010. https://www.ncbi.nlm.nih.gov/pubmed/19827025
37. Malic, Sladjana, Rachael P. C. Jordan, Mark G. J. Waters, David J. Stickler, and David W. Williams. “Biocide Activity against Urinary Catheter Pathogens.” Antimicrobial Agents and Chemotherapy 58, no. 2 (February 2014): 1192–94. doi:10.1128/AAC.01106-13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910826/
38. Husain, Fohad Mabood, Iqbal Ahmad, Mohammad Asif, and Qudsia Tahseen. “Influence of Clove Oil on Certain Quorum-Sensing-Regulated Functions and Biofilm of Pseudomonas Aeruginosa and Aeromonas Hydrophila.” Journal of Biosciences 38, no. 5 (December 2013): 835–44. https://www.ncbi.nlm.nih.gov/pubmed/24296886
39. Yadav, Mukesh Kumar, Seok-Won Park, Sung-Won Chae, Jae-Jun Song, and Ho Chul Kim. “Antimicrobial Activities of Eugenia Caryophyllata Extract and Its Major Chemical Constituent Eugenol against Streptococcus Pneumoniae.” APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica 121, no. 12 (December 2013): 1198–1206. doi:10.1111/apm.12067. https://www.ncbi.nlm.nih.gov/pubmed/23594212
40. Gupta, A., J. Duhan, S. Tewari, P. Sangwan, A. Yadav, G. Singh, R. Juneja, and H. Saini. “Comparative Evaluation of Antimicrobial Efficacy of Syzygium Aromaticum, Ocimum Sanctum and Cinnamomum Zeylanicum Plant Extracts against Enterococcus Faecalis: A Preliminary Study.” International Endodontic Journal 46, no. 8 (August 2013): 775–83. doi:10.1111/iej.12058. https://www.ncbi.nlm.nih.gov/pubmed/23506110
41. Khan, Mohd Sajjad Ahmad, and Iqbal Ahmad. “Biofilm Inhibition by Cymbopogon Citratus and Syzygium Aromaticum Essential Oils in the Strains of Candida Albicans.” Journal of Ethnopharmacology 140, no. 2 (March 27, 2012): 416–23. doi:10.1016/j.jep.2012.01.045. https://www.ncbi.nlm.nih.gov/pubmed/22326355
42. Xu, X., and A. Malavé. “Protective Effect of Berberine on Cyclophosphamide-Induced Haemorrhagic Cystitis in Rats.” Pharmacology & Toxicology 88, no. 5 (May 2001): 232–37. https://www.ncbi.nlm.nih.gov/pubmed/11393582
43. Kurashige, S., Y. Akuzawa, and F. Endo. “Effects of Astragali Radix Extract on Carcinogenesis, Cytokine Production, and Cytotoxicity in Mice Treated with a Carcinogen, N-Butyl-N’-Butanolnitrosoamine.” Cancer Investigation 17, no. 1 (1999): 30–35. https://www.ncbi.nlm.nih.gov/pubmed/10999046
44. Yang, D. A. “[Inhibitory effect of Chinese herb medicine zhuling on urinary bladder cancer. An experimental and clinical study].” Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery] 29, no. 6 (June 1991): 393–95, 399. https://www.ncbi.nlm.nih.gov/pubmed/1935440
45. Lee, Se-Jung, Hong-Man Kim, Young-Hwa Cho, Keerang Park, Eun-Jung Kim, Kyung-Hwan Jung, Cheorl-Ho Kim, Wun-Jae Kim, and Sung-Kwon Moon. “Aqueous Extract of Magnolia Officinalis Mediates Proliferative Capacity, p21WAF1 Expression and TNF-Alpha-Induced NF-kappaB Activity in Human Urinary Bladder Cancer 5637 Cells; Involvement of p38 MAP Kinase.” Oncology Reports 18, no. 3 (September 2007): 729–36. https://www.ncbi.nlm.nih.gov/pubmed/17671727
46. Kuo, Hann-Chorng, Yao-Chi Chuang, and Michael B Chancellor. “Neurourology, Diet, and Painful Bladder.” Reviews in Urology 10, no. 1 (2008): 70–72. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2312345/
47. Friedlander, Justin I., Barbara Shorter, and Robert M. Moldwin. “Diet and Its Role in Interstitial Cystitis/bladder Pain Syndrome (IC/BPS) and Comorbid Conditions.” BJU International 109, no. 11 (June 2012): 1584–91. doi:10.1111/j.1464-410X.2011.10860.x. https://www.ncbi.nlm.nih.gov/pubmed/22233286
48. Mansour, A., et. Al. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.”
49. Müller, Axel, Helge Franke, Karl-Ludwig Resch, and Gary Fryer. “Effectiveness of Osteopathic Manipulative Therapy for Managing Symptoms of Irritable Bowel Syndrome: A Systematic Review.” The Journal of the American Osteopathic Association 114, no. 6 (June 2014): 470–79. doi:10.7556/jaoa.2014.098. https://www.ncbi.nlm.nih.gov/pubmed/24917634
50. Alraek, T., and A. Baerheim. “‘An Empty and Happy Feeling in the Bladder.. .’: Health Changes Experienced by Women after Acupuncture for Recurrent Cystitis.” Complementary Therapies in Medicine 9, no. 4 (December 2001): 219–23. doi:10.1054/ctim.2001.0482. https://www.ncbi.nlm.nih.gov/pubmed/12184349