For people with neurological Lyme disease that have dementia, multiple sclerosis, or Alzheimer’s disease
by Greg Lee
One afternoon, I heard one of my daughters cry out with a huge scream after a wasp stung her arm. After she was taken care of, I got out my wasp fighting gear: electric bug zapper, thick gloves, hat, and a bottle of hair spray. You may be asking, “Why hair spray?” It sticks like glue to the wasp’s wings so they can’t fly and I don’t like pesticides. Once they hurt my girl, then it got personal and they had to go!
So it was me against over a dozen wasps. After zapping and spraying them into submission, I saw one of the wasps crawl into a slot between two deck boards. And then another wasp followed. I cautiously peered into the slot and saw the nest. I got out the garden hose and sprayed that nest until no wasp remained. Then I quickly pried it out and threw it down the sewer. Once the nest was gone, the rest got the message and didn’t return.
How is being stung by angry wasps defending their nest similar to nematodes that infect the brain?
Just like a wasp nest that swarms you, nematodes can infect and damage the brain
Recent research by Dr. Alan MacDonald has found worms called nematodes in autopsy brain tissue samples from patients with neurological Lyme disease who were also diagnosed with Multiple Sclerosis, dementia, brain tumors, and Alzheimer’s Disease. Lyme disease bacteria were actually detected within some of the nematodes. Similar to how wasps can hide in their nest, Lyme bacteria can hide from antibiotic treatment when they are inside of larger parasitic worms. Unfortunately, nematodes have also been detected in ticks.
In deer ticks and lone star ticks, nematodes have been detected
In multiple tick studies, nematodes have been detected in lone star ticks found in Maryland and Virginia, and in deer ticks from Connecticut. Ticks are capable of transmitting nematodes when they feed on a host. Other vectors that can transmit nematodes are mosquitoes and black flies. Once they infect a host, adult nematodes mate and then release thousands of very small larva called “microfilariae” into the blood. Microfilariae circulate throughout the host and can end up in the nervous system. These microfilariae evolve into larvae which can eat through the brain and can cause a wide range of symptoms.
Nematodes produce many symptoms when they infect the brain and spinal fluid
Larval nematodes in the nervous system can damage tissues and produce masses called granulomas. They can also cause fibrosis, blockages in cerebral blood vessels, or inflammation resulting in meningitis, encephalitis or localized inflammation, weakness, blurred vision, stomach flu, and even death. In a Taiwan study, patients infected with nematodes reported meningitis, brain inflammation, fever, vomiting, headache, and neuropathy. Two patients died from their infection. In some patients, nematodes were recovered from their cerebral-spinal fluid (CSF). Elevated levels of inflammatory markers vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and matrix metalloproteinase 9 (MMP-9) were also detected in patient’s CSF fluid. Research shows that nematodes can also manipulate the immune system response.
Nematodes produce compounds to deflect how the immune system attacks parasites
One research study on a nematode called B. Malayi, identified proteins that it releases to manipulate the immune response in favor of a parasitic infection. Another study on a filarial nematode infection illustrated how these parasites inhibit the inflammatory response by the immune system. In most cases, anti-parasitic medications are used to treat nematode infections in the nervous system.
Anti-parasitic medications help to kill nematode infections in the brain and spinal fluid
Anti-parasitic medications called antihelminthics are used to treat nematodes in the nervous system including: Mebendazole, Pyrantel pamoate, Thiabendazole, Diethylcarbamazine (DEC), Ivermectin, Moxidectin, and Alinia. Ivermectin and moxidectin are the most widely administrated antihelminthic medications for nematode infections and unfortunately, their widespread and frequent use has led to high level of resistance to these drugs. Ivermectin only kills the microfilariae, not the adult nematode. DEC can worsen onchocercal nematode eye infections. In patients with a nematode infection called loiasis, DEC can cause serious adverse reactions, including encephalopathy and death, depending upon the density of the parasites. DEC is only available in the US from the CDC upon submitting positive lab results. A mechanism within nematodes called a “drug effux pump” is believed to enable these parasites to develop drug resistance. Killing nematodes can lead to significant Herxheimer reactions.
A symbiotic bacteria within nematodes is the source of Herxheimer toxins
Wolbachia is a symbiotic bacteria which enables normal development and fertility of nematodes. Wolbachia belong to the order Rickettsiales and is closely related to Anaplasma, Ehrlichia and Rickettsia. Fortunately, this bacteria does not infect people. When nematodes are killed off by anti-parasitic drugs, Wolbachia cannot survive without their host and are killed, which releases their endotoxins. Wolbachia toxins stimulate the production of pro-inflammatory compounds including tumor necrosis factor alpha (TNF)-alpha, Interleukin-1 (IL-1), and Interleukin-12 (IL-12). In an animal study, Wolbachia surface protein upregulated (IL)-1beta, IL-6, and tumor necrosis factor. These endotoxins and inflammatory compounds can produce painful symptoms associated with a Herxheimer reaction. A combination of anti-parasitic and antibiotic medications is more effective at reducing adult and microfilariae forms of nematodes.
A combination of medications which kill both the adult and microfilariae forms is more effective
Recent drug strategies combine Ivermectin for microfilariae and doxycycline to kill Wolbachia which eventually kills the adult nematodes in the nervous system. This combination drug treatment is recommended for six weeks. Another animal study combined DEC with liposomal doxycycline and liposomal rifampin resulting in significant increase in microfilariae die off and a marginal increase in the die off of adult nematodes. Other studies demonstrate the inhibitory effect of anti-Rickettsia antibiotics like tetracycline, rifampin, and azithromyacin on adult nematodes.
What else can help people to expel brain-eating nematodes from their central nervous system who have persistent neurological Lyme disease, multiple sclerosis, dementia, brain tumors, or Alzheimer’s disease?
Here are four strategies for expelling brain-eating nematodes from the central nervous system
A combination of remedies for attacking both the adult and microfilariae forms is the most effective at reducing the overall numbers of parasites. Formulating remedies into microparticles called liposomes enhances the efficacy of anti-parasitic herbs and essential oils for killing the different life stages of nematodes and possibly their symbiotic bacteria.
Clearing Brain-Eating Nematodes Strategy #1: Essential Oils
Essential oils have been found to inhibit different species of nematodes.
Thyme essential oil was effective at inhibiting Meloydogine javanica and larvae from the Anisakis nematode. Thyme essential oil was also effective against gram negative bacteria: Pseudomonas aeruginosa, Salmonella spp., and E. Coli. Thyme combined with oregano oil reduced mRNA levels of pro-inflammatory cytokines IL-1beta, IL-6, GM-CSF, and TNFalpha.
Palmarosa essential oil was effective against Caenorhabditis elegans and Haemonchus contortus in separate studies. This oil was also effective at inhibiting E. Coli and Aspergillus fumigatus. Palmarosa oil also reduced pro-inflammatory compounds TNF-α, IL-1β, and IL-8 and increased anti-inflammatory IL-10 in lab studies.
Clove bud essential oil was highly effective at reducing Meloidogyne incognita egg hatch 50% and killing second stage juveniles (J2) as much as 100% in a lab study. Eugenol, the primary compound in clove bud oil, in one rat study reduced expression of VEGF, MMP-2, and MMP-9, which are elevated in nematode infections. Processing these oils into a liposomal micronized form increases their penetration into the nervous system. Adding nanoparticles of silver to liposomal oils may further enhance their anti-microbial properties.
Clearing Brain-Eating Nematodes Strategy #2: Nanoparticle Silver
In multiple lab studies, nanoparticles of silver were effective at reducing motility and killing microfilariae of Brugia malayi, demonstrated antifilarial activity against microfilaria of S. Cervi, disrupted metabolism of Caenorhabditis elegans, and killed most of Meloidogyne incognita. Encapsulating nanoparticles of silver along with essential oils into a liposomal remedy may increase their anti-parasitic and anti-symbiotic bacterial properties. When nanoparticle silver is combined with tea tree essential oil into a liposome, their antimicrobial efficiency is enhanced against Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Silver nanoparticles may reduce inflammation from nematodes by inhibiting IL-1beta and VEGF induced permeability as reported in a pig study and reducing MMP-2 and MMP-9 in another rat study. Herbs have also been effective for treating nematode infections for thousands of years.
Clearing Brain-Eating Nematodes Strategy #3: Herbs
In addition to essential oils and silver, herbs have been used for centuries for fighting nematode infections.
Andrographis, Chinese name Chuan Xin Lian, has been effective at inhibiting Haemonchus contortus, microfilaricidal activity against Dirofilaria immitis filarids, antifilarial activity against adult worms of subperiodic Brugia malayi, killing in vitro the microfilaria of Dipetalonema reconditum in dogs, and anthelmintic activity against Ascaris lumbricoides. This herb is also used in Chinese medicine against leptospirosis, another spirochete infection. Andrographis was also effective at reducing inflammatory compounds IL-1α, IL-1β, and IL-6 in a lab study. A compound in Andrographis called andrographolide inhibits expression of inflammatory compounds MMP-2, IL-1beta and VEGF in lab studies.
Ajowan, ajwain, or Trachyspermum ammi has been effective against multiple species of nematodes in multiple studies. Methanolic extract of fruits of Trachyspermum ammi were effective against adult bovine filarial Setaria digitata worms and demonstrated macrofilaricidal activity and female worm sterility in vivo against B. Malayi.
Lantana camara is an ornamental shrub which is very hardy and is used medicinally through much of the world. This herb contains triterpenoids pomolic acid, lantanolic acid, lantoic acid, camarin, lantacin, camarinin, and ursolic acid which exhibited 100% mortality in 24 – 48 hours against the nematode Meloidogyne incognita. In other studies, a lantana extract killed adult Brugia malayi nematodes and sterilized many of the surviving female worms, and demonstrated strong microfilaricidal and sterilization efficacy with mild macrofilaricidal action against Acanthocheilonema viteae. Not only herbs, but also tiny electrical frequencies can help to stop nematodes that have infected the brain and spinal fluid.
Clearing Brain-Eating Nematodes Strategy #4: Frequency Specific Microcurrent
Frequency Specific Microcurrent uses millionth of an amp electrical currents to reduce parasitic and bacterial infections, toxins and inflammation. Frequencies for inhibiting parasitic worms, symbiotic bacteria, neutralizing toxins and inflammation, reducing tumors, and promoting healing are paired with frequencies to target infected areas of the nervous system: the brain, forebrain, meninges, basal ganglia, spinal cord, spinal fluid, cranial nerves, and eyes. These paired frequencies have also been helpful in reducing symptoms in patients diagnosed with multiple sclerosis, autism, brain inflammation, mold toxicity, and neurological Lyme disease. These four strategies may help people with neurological Lyme to stop an underlying parasitic nematode brain infection.
A combination of anti-parasitic remedies and treatments can help to overcome a chronic neurological Lyme and nematode infection
People diagnosed with multiple sclerosis, Alzheimer’s disease, dementia, or brain tumors may have hidden parasitic nematodes along with Lyme disease in their nervous system. Just like finding and eliminating the wasp nest, expelling parasitic nematodes that harbor Lyme bacteria may help to improve neurological symptoms and memory recall. Using liposomal anti-parasitic and anti-symbiotic bacteria remedies and treatments may be effective in eliminating larger parasites and the Lyme bacteria they contain.
Anti-toxin treatments and remedies may also help with reducing inflammatory compounds which may lower toxic Herxheimer pain and discomfort. Making these remedies into micronized liposomes enhances their delivery into the nervous system and may increase their anti-nematode effectiveness. Since some of these treatments and remedies require specialized training, work with a Lyme literate natural remedy practitioner to develop a proper, safe, and effective strategy for your condition.
>> Next step: Click here to watch my presentation, “Five Game-Changing Lyme Remedies” on the Best of Chronic Lyme Summit (free for first-time viewers).
 “Borrelia Dwells in Parasitic Nematodes in Glioma & Neurodegenerative Disease.” Dr. Paul Duray Research Fellowship Endowment Inc, May 14, 2016. https://durayresearch.wordpress.com/borrelia-dwells-in-parasitic-nematodes-in-neurodegenerative-disease/.
 Zhang, Xing, Douglas E. Norris, and Jason L. Rasgon. “Distribution and Molecular Characterization of Wolbachia Endosymbionts and Filarial Nematodes in Maryland Populations of the Lone Star Tick (Amblyomma Americanum).” FEMS Microbiology Ecology 77, no. 1 (July 2011): 50–56. doi:10.1111/j.1574-6941.2011.01089.x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118304/
 Henning, Tyler C., John M. Orr, Joshua D. Smith, Jorge R. Arias, Jason L. Rasgon, and Douglas E. Norris. “Discovery of Filarial Nematode DNA in Amblyomma Americanum in Northern Virginia.” Ticks and Tick-Borne Diseases 7, no. 2 (March 2016): 315–18. doi:10.1016/j.ttbdis.2015.11.007. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876860/
 Namrata, Pabbati, Jamie M. Miller, Madari Shilpa, Patlolla Raghavender Reddy, Cheryl Bandoski, Michael J. Rossi, and Eva Sapi. “Filarial Nematode Infection in Ixodes Scapularis Ticks Collected from Southern Connecticut.” Veterinary Sciences 1, no. 1 (May 12, 2014): 5–15. doi:10.3390/vetsci1010005. https://www.mdpi.com/2306-7381/1/1/5
 Balashov, Iu S. “[The interrelationships of ixodid ticks (Ixodidae) with the causative agents of transmissible vertebrate infections].” Parazitologiia 29, no. 5 (October 1995): 337–52. https://www.ncbi.nlm.nih.gov/pubmed/8524614
 “Filariasis.” Wikipedia, the Free Encyclopedia, June 2, 2016. https://en.wikipedia.org/w/index.php?title=Filariasis&oldid=723361310.
 “Filariasis.” Wikipedia, the Free Encyclopedia, June 2, 2016. https://en.wikipedia.org/w/index.php?title=Filariasis&oldid=723361310.
 Bhalla, Devender, Michel Dumas, and Pierre-Marie Preux. “Neurological Manifestations of Filarial Infections.” Handbook of Clinical Neurology 114 (2013): 235–42. doi:10.1016/B978-0-444-53490-3.00018-2. https://www.ncbi.nlm.nih.gov/pubmed/23829914
 Wan, Kong-Sang, and Wen-Chein Weng. “Eosinophilic Meningitis in a Child Raising Snails as Pets.” Acta Tropica 90, no. 1 (March 2004): 51–53. https://www.ncbi.nlm.nih.gov/pubmed/14739022
 Tsai, Hung-Chin, Yao-Shen Chen, and Chuan-Min Yen. “Human Parasitic Meningitis Caused by Angiostrongylus Cantonensis Infection in Taiwan.” Hawai’i Journal of Medicine & Public Health 72, no. 6 Suppl 2 (June 2013): 26–27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689489/
 Zamanian, Mostafa, Lisa M. Fraser, Prince N. Agbedanu, Hiruni Harischandra, Andrew R. Moorhead, Tim A. Day, Lyric C. Bartholomay, and Michael J. Kimber. “Release of Small RNA-Containing Exosome-like Vesicles from the Human Filarial Parasite Brugia Malayi.” PLoS Neglected Tropical Diseases 9, no. 9 (2015): e0004069. doi:10.1371/journal.pntd.0004069. https://www.ncbi.nlm.nih.gov/pubmed/26401956
 Boyd, Alexis, Sasisekhar Bennuru, Yuanyuan Wang, Vivornpun Sanprasert, Melissa Law, Damien Chaussabel, Thomas B. Nutman, and Roshanak Tolouei Semnani. “Quiescent Innate Response to Infective Filariae by Human Langerhans Cells Suggests a Strategy of Immune Evasion.” Infection and Immunity 81, no. 5 (May 2013): 1420–29. doi:10.1128/IAI.01301-12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648007/
 “Antiparasitic.” Wikipedia, the Free Encyclopedia, January 13, 2016. https://en.wikipedia.org/w/index.php?title=Antiparasitic&oldid=699638003
 Awadzi, Kwablah, Nicholas O. Opoku, Simon K. Attah, Janis Lazdins-Helds, and Annette C. Kuesel. “A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca Volvulus Infection.” PLoS Neglected Tropical Diseases 8, no. 6 (June 2014): e2953. doi:10.1371/journal.pntd.0002953. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072596/
 Bojar, Hubert, and Józef P. Knap. “[Nitazoxanide (‘Alinia’)–a promising antiparasitic drug].” Wiadomości Parazytologiczne 56, no. 1 (2010): 11–18. https://www.ncbi.nlm.nih.gov/pubmed/20450003
 Ménez, Cécile, Mélanie Alberich, Dalia Kansoh, Alexandra Blanchard, and Anne Lespine. “Acquired Tolerance to Ivermectin and Moxidectin after Drug Selection Pressure in the Nematode Caenorhabditis Elegans.” Antimicrobial Agents and Chemotherapy, May 31, 2016. doi:10.1128/AAC.00713-16. https://www.ncbi.nlm.nih.gov/pubmed/27246778
 Prevention, CDC-Centers for Disease Control and. “CDC – Lymphatic Filariasis – Treatment.” Accessed June 22, 2016. https://www.cdc.gov/parasites/lymphaticfilariasis/treatment.html.
 Prevention, CDC-Centers for Disease Control and. “CDC – Lymphatic Filariasis – Treatment.” Accessed June 22, 2016. https://www.cdc.gov/parasites/lymphaticfilariasis/treatment.html.
 Whittaker, J. H., S. A. Carlson, D. E. Jones, and M. T. Brewer. “Molecular Mechanisms for Anthelmintic Resistance in Strongyle Nematode Parasites of Veterinary Importance.” Journal of Veterinary Pharmacology and Therapeutics, June 15, 2016. doi:10.1111/jvp.12330. https://www.ncbi.nlm.nih.gov/pubmed/27302747
 Taylor, Mark J., Claudio Bandi, and Achim Hoerauf. “Wolbachia Bacterial Endosymbionts of Filarial Nematodes.” Advances in Parasitology 60 (2005): 245–84. doi:10.1016/S0065-308X(05)60004-8. https://www.ncbi.nlm.nih.gov/pubmed/16230105
 “Wolbachia.” Wikipedia, the Free Encyclopedia, June 7, 2016. https://en.wikipedia.org/w/index.php?title=Wolbachia&oldid=724092586
 T/sillassie, Henok, and Mengistu Legesse. “The Role of Wolbachia Bacteria in the Pathogenesis of Onchocerciasis and Prospects for Control of the Disease.” Ethiopian Medical Journal 45, no. 2 (April 2007): 213–19. https://www.ncbi.nlm.nih.gov/pubmed/17642180
 Porksakorn, Chantima, Surang Nuchprayoon, Kiwon Park, and Alan L. Scott. “Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to Brugia Malayi Wolbachia Surface Protein.” Mediators of Inflammation 2007 (2007): 84318. doi:10.1155/2007/84318. https://www.ncbi.nlm.nih.gov/pubmed/17641731
 Debrah, Alexander Yaw, Sabine Specht, Ute Klarmann-Schulz, Linda Batsa, Sabine Mand, Yeboah Marfo-Debrekyei, Rolf Fimmers, et al. “Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca Volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 61, no. 4 (August 15, 2015): 517–26. doi:10.1093/cid/civ363. https://www.ncbi.nlm.nih.gov/pubmed/25948064
 Dangi, Anil, Varun Dwivedi, Satish Vedi, Mohammad Owais, and Shailja Misra-Bhattacharya. “Improvement in the Antifilarial Efficacy of Doxycycline and Rifampicin by Combination Therapy and Drug Delivery Approach.” Journal of Drug Targeting 18, no. 5 (June 2010): 343–50. doi:10.3109/10611860903450007. https://www.ncbi.nlm.nih.gov/pubmed/19954408
 Mahajan, Rachna, K. Goswami, S. Hande, P. Bhoj. “Evolution of Anti-Filarial Therapeutics: An Overview.” Accessed June 15, 2016. https://jmaa.co.uk/articles/4JMAA-16-22.2015MAHAJAN-.pdf.
 Ali, Mohammad, Mohammad Afzal, Shailja Misra Bhattacharya, Farhan Jalees Ahmad, and Amit Kumar Dinda. “Nanopharmaceuticals to Target Antifilarials: A Comprehensive Review.” Expert Opinion on Drug Delivery 10, no. 5 (May 2013): 665–78. doi:10.1517/17425247.2013.771630. https://www.ncbi.nlm.nih.gov/pubmed/23427945
 Santana, Omar, Maria Fe Andrés, Jesús Sanz, Naima Errahmani, Lamiri Abdeslam, and Azucena González-Coloma. “Valorization of Essential Oils from Moroccan Aromatic Plants.” Natural Product Communications 9, no. 8 (August 2014): 1109–14. https://www.ncbi.nlm.nih.gov/pubmed/25233584
 Giarratana, F., D. Muscolino, C. Beninati, A. Giuffrida, and A. Panebianco. “Activity of Thymus Vulgaris Essential Oil against Anisakis Larvae.” Experimental Parasitology 142 (July 2014): 7–10. doi:10.1016/j.exppara.2014.03.028. https://www.ncbi.nlm.nih.gov/pubmed/24721259
 Kavanaugh, Nicole L., and Katharina Ribbeck. “Selected Antimicrobial Essential Oils Eradicate Pseudomonas Spp. and Staphylococcus Aureus Biofilms.” Applied and Environmental Microbiology 78, no. 11 (June 1, 2012): 4057–61. doi:10.1128/AEM.07499-11. https://aem.asm.org/content/78/11/4057.full
 Nzeako, B C, Zahra S N Al-Kharousi, and Zahra Al-Mahrooqui. “Antimicrobial Activities of Clove and Thyme Extracts.” Sultan Qaboos University Medical Journal 6, no. 1 (June 2006): 33–39. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074903/
 Inouye, Shigeharu, Toshio Takizawa, and Hideyo Yamaguchi. “Antibacterial Activity of Essential Oils and Their Major Constituents against Respiratory Tract Pathogens by Gaseous Contact.” Journal of Antimicrobial Chemotherapy 47, no. 5 (May 1, 2001): 565–73. doi:10.1093/jac/47.5.565. https://jac.oxfordjournals.org/content/47/5/565.full
 Bukovská, Alexandra, Stefan Cikos, Stefan Juhás, Gabriela Il’ková, Pavol Rehák, and Juraj Koppel. “Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice.” Mediators of Inflammation 2007 (2007): 23296. doi:10.1155/2007/23296. https://www.ncbi.nlm.nih.gov/pubmed/18288268
 Kumaran, Asha M., Prashanth D’Souza, Amit Agarwal, Rama Mohan Bokkolla, and Murali Balasubramaniam. “Geraniol, the Putative Anthelmintic Principle of Cymbopogon Martinii.” Phytotherapy Research: PTR 17, no. 8 (September 2003): 957. doi:10.1002/ptr.1267. https://www.ncbi.nlm.nih.gov/pubmed/13680833
 Katiki, L. M., A. C. S. Chagas, H. R. Bizzo, J. F. S. Ferreira, and A. F. T. Amarante. “Anthelmintic Activity of Cymbopogon Martinii, Cymbopogon Schoenanthus and Mentha Piperita Essential Oils Evaluated in Four Different in Vitro Tests.” Veterinary Parasitology 183, no. 1–2 (December 29, 2011): 103–8. doi:10.1016/j.vetpar.2011.07.001. https://www.ncbi.nlm.nih.gov/pubmed/21820807
 Duarte, Marta Cristina Teixeira, Ewerton Eduardo Leme, Camila Delarmelina, Andressa Almeida Soares, Glyn Mara Figueira, and Adilson Sartoratto. “Activity of Essential Oils from Brazilian Medicinal Plants on Escherichia Coli.” Journal of Ethnopharmacology 111, no. 2 (May 4, 2007): 197–201. doi:10.1016/j.jep.2006.11.034. https://www.ncbi.nlm.nih.gov/pubmed/17210236
 Khan, Mohd Sajjad Ahmad, and Iqbal Ahmad. “In Vitro Antifungal, Anti-Elastase and Anti-Keratinase Activity of Essential Oils of Cinnamomum-, Syzygium- and Cymbopogon-Species against Aspergillus Fumigatus and Trichophyton Rubrum.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 19, no. 1 (December 15, 2011): 48–55. doi:10.1016/j.phymed.2011.07.005. https://www.ncbi.nlm.nih.gov/pubmed/21893402
 Tsai, Mei-Lin, Chih-Chien Lin, Wei-Chao Lin, and Chao-Hsun Yang. “Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs.” Bioscience, Biotechnology, and Biochemistry 75, no. 10 (2011): 1977–83. https://www.ncbi.nlm.nih.gov/pubmed/21979069
 Murbach Teles Andrade, Bruna Fernanda, Bruno José Conti, Karina Basso Santiago, Ary Fernandes Júnior, and José Maurício Sforcin. “Cymbopogon Martinii Essential Oil and Geraniol at Noncytotoxic Concentrations Exerted Immunomodulatory/anti-Inflammatory Effects in Human Monocytes.” The Journal of Pharmacy and Pharmacology 66, no. 10 (October 2014): 1491–96. doi:10.1111/jphp.12278. https://www.ncbi.nlm.nih.gov/pubmed/24934659
 Meyer, Susan LF, Dilip K Lakshman, Inga A Zasada, Bryan T Vinyard, and David J Chitwood. “Dose–response Effects of Clove Oil fromSyzygium Aromaticum on the Root-Knot nematodeMeloidogyne Incognita.” Pest Management Science 64, no. 3 (March 2008): 223–29. doi:10.1002/ps.1502. https://www.researchgate.net/publication/5768878_Dose-response_effects_of_clove_oil_from_Syzygium_aromaticum_on_the_root-knot_nematode_Meloidogyne_incognita
 Meyer, Susan LF, Dilip K Lakshman, Inga A Zasada, Bryan T Vinyard, and David J Chitwood. “Dose–response Effects of Clove Oil from Syzygium Aromaticum on the Root-Knot Nematode Meloidogyne Incognita.” Pest Management Science 64, no. 3 (March 2008): 223–29. doi:10.1002/ps.1502. https://www.ncbi.nlm.nih.gov/pubmed/18080287
 Manikandan, Palrasu, Ramalingam Senthil Murugan, Ramamurthi Vidya Priyadarsini, Govindarajah Vinothini, and Siddavaram Nagini. “Eugenol Induces Apoptosis and Inhibits Invasion and Angiogenesis in a Rat Model of Gastric Carcinogenesis Induced by MNNG.” Life Sciences 86, no. 25–26 (June 19, 2010): 936–41. doi:10.1016/j.lfs.2010.04.010. https://www.ncbi.nlm.nih.gov/pubmed/20434464
 Shibata, S., A. Ochi, and K. Mori. “Liposomes as Carriers of Cisplatin into the Central Nervous System–Experiments with 9L Gliomas in Rats.” Neurologia Medico-Chirurgica 30, no. 4 (April 1990): 242–45. https://www.ncbi.nlm.nih.gov/pubmed/1696693
 Singh, Sunil K., Kalyan Goswami, Richa D. Sharma, Maryada V. R. Reddy, and Debabrata Dash. “Novel Microfilaricidal Activity of Nanosilver.” International Journal of Nanomedicine 7 (2012): 1023–30. doi:10.2147/IJN.S28758. https://www.ncbi.nlm.nih.gov/pubmed/22393295
 Saini, Prasanta, Swadhin Kr Saha, Priya Roy, Pranesh Chowdhury, and Santi P. Sinha Babu. “Evidence of Reactive Oxygen Species (ROS) Mediated Apoptosis in Setaria Cervi Induced by Green Silver Nanoparticles from Acacia Auriculiformis at a Very Low Dose.” Experimental Parasitology 160 (January 2016): 39–48. doi:10.1016/j.exppara.2015.11.004. https://www.ncbi.nlm.nih.gov/pubmed/26627139
 Starnes, Daniel L., Stuart S. Lichtenberg, Jason M. Unrine, Catherine P. Starnes, Emily K. Oostveen, Gregory V. Lowry, Paul M. Bertsch, and Olga V. Tsyusko. “Distinct Transcriptomic Responses of Caenorhabditis Elegans to Pristine and Sulfidized Silver Nanoparticles.” Environmental Pollution (Barking, Essex: 1987) 213 (June 2016): 314–21. doi:10.1016/j.envpol.2016.01.020. https://www.ncbi.nlm.nih.gov/pubmed/26925754
 Cromwell, W. A., Joopil Yang, J. L. Starr, and Young-Ki Jo. “Nematicidal Effects of Silver Nanoparticles on Root-Knot Nematode in Bermudagrass.” Journal of Nematology 46, no. 3 (September 2014): 261–66. https://www.ncbi.nlm.nih.gov/pubmed/25275999
 Low, W. L., C. Martin, D. J. Hill, and M. A. Kenward. “Antimicrobial Efficacy of Liposome-Encapsulated Silver Ions and Tea Tree Oil against Pseudomonas Aeruginosa, Staphylococcus Aureus and Candida Albicans.” Letters in Applied Microbiology 57, no. 1 (July 2013): 33–39. doi:10.1111/lam.12082. https://www.ncbi.nlm.nih.gov/pubmed/23581401
 Sheikpranbabu, Sardarpasha, Kalimuthu Kalishwaralal, Deepak Venkataraman, Soo Hyun Eom, Jongsun Park, and Sangiliyandi Gurunathan. “Silver Nanoparticles Inhibit VEGF-and IL-1β-Induced Vascular Permeability via Src Dependent Pathway in Porcine Retinal Endothelial Cells.” Journal of Nanobiotechnology 7 (2009): 8. doi:10.1186/1477-3155-7-8. https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-7-8
 Liu, Binbin. “In Vitro Cytotoxicity of Silver Nanoparticles in Primary Rat Hepatic Stellate Cells.” Molecular Medicine Reports, September 13, 2013. doi:10.3892/mmr.2013.1683. https://www.spandidos-publications.com/mmr/8/5/1365
 Kamaraj, Chinnaperumal, Abdul Abdul Rahuman, Gandhi Elango, Asokan Bagavan, and Abdul Abduz Zahir. “Anthelmintic Activity of Botanical Extracts against Sheep Gastrointestinal Nematodes, Haemonchus Contortus.” Parasitology Research 109, no. 1 (July 2011): 37–45. doi:10.1007/s00436-010-2218-y. https://www.ncbi.nlm.nih.gov/pubmed/21161270
 Merawin, L. T., A. K. Arifah, R. A. Sani, M. N. Somchit, A. Zuraini, S. Ganabadi, and Z. A. Zakaria. “Screening of Microfilaricidal Effects of Plant Extracts against Dirofilaria Immitis.” Research in Veterinary Science 88, no. 1 (February 2010): 142–47. doi:10.1016/j.rvsc.2009.05.017. https://www.ncbi.nlm.nih.gov/pubmed/19500810
 Zaridah, M. Z., S. Z. Idid, A. W. Omar, and S. Khozirah. “In Vitro Antifilarial Effects of Three Plant Species against Adult Worms of Subperiodic Brugia Malayi.” Journal of Ethnopharmacology 78, no. 1 (November 2001): 79–84. https://www.ncbi.nlm.nih.gov/pubmed/11585692
 Dutta, A., and N. C. Sukul. “Filaricidal Properties of a Wild Herb, Andrographis Paniculata.” Journal of Helminthology 56, no. 2 (June 1982): 81–84. https://www.ncbi.nlm.nih.gov/pubmed/7201486
 Raj, R. K. “Screening of Indigenous Plants for Anthelmintic Action against Human Ascaris Lumbricoides: Part–II.” Indian Journal of Physiology and Pharmacology 19, no. 1 (March 1975): UNKNOWN. https://www.ncbi.nlm.nih.gov/pubmed/1158424
 “Lyme Disease: Treatment with Chinese Herbs.” Accessed June 23, 2016. https://www.itmonline.org/arts/lyme.htm.
 Salim, Emil, Endang Kumolosasi, and Ibrahim Jantan. “Inhibitory Effect of Selected Medicinal Plants on the Release of pro-Inflammatory Cytokines in Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells.” Journal of Natural Medicines 68, no. 3 (July 2014): 647–53. doi:10.1007/s11418-014-0841-0. https://www.ncbi.nlm.nih.gov/pubmed/24799081
 Tangyuenyong, Siriwan, Nawarat Viriyakhasem, Siriporn Peansukmanee, Prachya Kongtawelert, Siriwan Ongchai, Siriwan Tangyuenyong, Nawarat Viriyakhasem, Siriporn Peansukmanee, Prachya Kongtawelert, and Siriwan Ongchai. “Andrographolide Exerts Chondroprotective Activity in Equine Cartilage Explant and Suppresses Interleukin-1β-Induced MMP-2 Expression in Equine Chondrocyte Culture, Andrographolide Exerts Chondroprotective Activity in Equine Cartilage Explant and Suppresses Interleukin-1β-Induced MMP-2 Expression in Equine Chondrocyte Culture.” International Scholarly Research Notices, International Scholarly Research Notices 2014, 2014 (October 30, 2014): e464136. doi:10.1155/2014/464136, 10.1155/2014/464136. https://www.hindawi.com/journals/isrn/2014/464136/
 Zhao, Feng, En-Qi He, Lu Wang, and Ke Liu. “Anti-Tumor Activities of Andrographolide, a Diterpene from Andrographis Paniculata, by Inducing Apoptosis and Inhibiting VEGF Level.” Journal of Asian Natural Products Research 10, no. 5–6 (June 2008): 467–73. doi:10.1080/10286020801948334. https://www.ncbi.nlm.nih.gov/pubmed/18464090
 Mathew, Nisha, Shailja Misra-Bhattacharya, Vanamail Perumal, and Kalyanasundaram Muthuswamy. “Antifilarial Lead Molecules Isolated from Trachyspermum Ammi.” Molecules (Basel, Switzerland) 13, no. 9 (2008): 2156–68. https://www.ncbi.nlm.nih.gov/pubmed/18830147
 Begum, Sabira, Syeda Qamar Zehra, Bina Shaheen Siddiqui, Shahina Fayyaz, and Musarrat Ramzan. “Pentacyclic Triterpenoids from the Aerial Parts of Lantana Camara and Their Nematicidal Activity.” Chemistry & Biodiversity 5, no. 9 (September 2008): 1856–66. doi:10.1002/cbdv.200890173. https://www.ncbi.nlm.nih.gov/pubmed/18816515
 Misra, Namita, Mithilesh Sharma, Kanwal Raj, Anil Dangi, Sudhir Srivastava, and Shailja Misra-Bhattacharya. “Chemical Constituents and Antifilarial Activity of Lantana Camara against Human Lymphatic Filariid Brugia Malayi and Rodent Filariid Acanthocheilonema Viteae Maintained in Rodent Hosts.” Parasitology Research 100, no. 3 (February 2007): 439–48. doi:10.1007/s00436-006-0312-y. https://www.ncbi.nlm.nih.gov/pubmed/17061115
 DC, Carolyn McMakin MA. Frequency Specific Microcurrent in Pain Management, 1e. 1 Pap/Dvdr edition. Edinburgh ; New York: Churchill Livingstone, 2011.
 Walker, M.D., and J.R. Zunt. “Neuroparasitic Infections: Nematodes.” Seminars in Neurology 25, no. 3 (September 2005): 252–61. doi:10.1055/s-2005-917662. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678030/
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