Apr 2 17

Can These Five Remedies Take the Daily Pain Out of Lyme Disease and Co-Infections?

by Greg

For people with Lyme disease and co-infections that have severe pain due to elevated levels of Substance P in the nervous system

by Greg Lee

When I was a boy, my friends and I would bike to the local novelty store. I would buy the baseball cards and gum. One of my friends would always buy the pranks: plastic bugs, fake vomit, and the garlic flavored candy. One day, he tricked me with a chewing gum pack that had a hidden wire spring. As I took the stick of gum, it snapped on my finger. Yow!

How is chronic pain due to elevated Substance P in people with Lyme and co-infections just like getting your finger caught in a chewing gum prank?

Similar to getting your finger snapped in a chewing gum prank, people with pain syndromes have elevated levels of Substance P
Substance P is a neuropeptide which acts as a neurotransmitter and neuromodulator[1]. It can be found throughout the body. This peptide can activate mast cells to release inflammatory compounds. It is highly correlated with levels of pain in people diagnosed with Fibromyalgia[2], chronic migraines[3], osteoarthritis, rheumatoid arthritis[4], Complex Regional Pain Syndrome (CRPS)[5], Chronic Pelvic Pain Syndrome (CPPS)[6], chronic neck pain[7], inflammatory bowel disease (IBD), irritable bowel syndrome (IBS)[8], chronic degenerative disc disease[9], and carpal tunnel syndrome[10]. Substance P has also been indicated in patients with depression, anxiety[11], brain parasites[12], neuroinflammation[13], inflammation, hepatitis, hepatotoxicity, cholestasis, pruritus, myocarditis, bronchiolitis, abortus, bacteria and viral infections[14]. Unfortunately, Substance P may aggravate neurological problems in people with Lyme disease.

Substance P may aggravate neurological problems in people with Lyme disease
In one animal study, Substance P contributed increases in blood-brain barrier permeability, neurological damage, increased CNS infection, and elevated numbers of microglia/macrophages in mice with a Lyme disease central nervous system (CNS) infection[15]. In another lab study, Substance P aggravated the release of inflammatory compounds COX-2 and PGE(2) in mouse brain cells[16]. Another study suggests that Substance P contributes to CNS inflammation in neurological Lyme disease patients[17]. Substance P is often elevated in electrical frequency scans of Lyme patients that report chronic pain. Medications can help with reducing some Substance P symptoms.

A new type of medication called Neurokinin 1 (NK1) antagonists can help with Substance P symptoms
NK1 antagonists have helped relieve depression, anxiety, and vomiting in patients with elevated levels of Substance P[18]. By modulating serotonin and norepinephrine, they help relieve emotional symptoms. Unfortunately, most studies indicate that NK1 antagonists are not effective at relieving pain caused by elevated levels of Substance P[19]. Many patients use opioid pain relief medications which can have side effects including: constipation, nausea, and addiction.

What else can help relieve chronic pain caused by elevated levels of Substance P in people with Lyme disease?

Here are five remedies for reducing pain caused by elevated Substance P
In human, animal, and lab studies, there are five natural remedies which have pain relieving and anti-inflammatory effects in Substance P pain experiments. By processing remedies into microparticles called liposomes, has enabled remedies to be delivered more effectively into the brain[20] to counteract Substance P’s effects of increased neurological inflammation. Liposomal analgesic medications are more effective at relieving pain than their non-liposomal equivalent[21]. Liposomal remedies have also been effective at reducing the production of inflammatory cytokines in a mouse study[22]. Fortunately, liposomal encapsulation and delivery of essential oils and herbs may enhance their penetration and effectiveness against Substance P pain and neurological inflammation in Lyme patients.

Pain Relieving, Anti-Substance P Remedy #1: Peppermint Essential Oil
Peppermint essential oil was effective at inhibiting Substance P smooth muscle contraction in one animal study[23]. In a human study, peppermint oil combined with ethanol was effective at relieving headache pain[24]. Do not apply peppermint oil undiluted to the feet of children under 12 years old, avoid large doses, it may cause heartburn, perianal burning, blurred vision, nausea and vomiting when taken internally. Peppermint essential oil use is contraindicated in children under 30 months old, and people should avoid the intake of peppermint oil with gallbladder disease, severe liver damage, gallstones, chronic heartburn[25], and cases of cardiac fibrillation and in patients with a G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency[26]. Nutmeg essential oil may also help to reduce Substance P pain.

Pain Relieving, Anti-Substance P Remedy #2: Nutmeg Essential Oil
Nutmeg essential oil was effective at reducing chronic inflammatory pain through inhibition of COX-2 expression and substance P release in one rat study[27]. Maximum daily internal dose for nutmeg oil is 73 mg and 4% topically. In large doses may produce psychotropic effects[28]. Tea tree is another essential oil that may also help to relieve Substance P pain.

Pain Relieving, Anti-Substance P Remedy #3: Tea Tree Essential Oil
In a human skin and rat skin study, tea tree oil and it’s active compounds reduced Substance P induced microvascular changes, histamine, and inflammatory response[29]. In other studies, tea tree oil assists in wound healing and reduces inflammatory compounds[30]. This oil has a low risk of dermal irritation. Maximum safe dermal use is 15%. Caution: high doses, approximately a teaspoon to a half a teacup, of tea tree oil have resulted in ataxia, drowsiness, diarrhea, unconsciousness, and allergic reactions[31]. Angelica sinensis is an herb that may also help to treat pain from elevated Substance P.

Pain Relieving, Anti-Substance P Remedy #4: Angelica Sinensis Herb
In one mouse study, Angelica sinensis reduced levels of Substance P, the number of mast cells, inflammatory cytokines: Interleukin-4 (IL-4), Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and Interferon-gamma (IFN-γ), as well as the expressions of nuclear factor kappa-beta (NF-κB)[32]. This herb has been used for hundreds of years in Chinese medicine for relieving pain, lubricating the intestines, and treating female irregular menstruation and amenorrhea. It has also been used extensively for treating anemia and other blood disorders by tonifying, replenishing, and invigorating blood. A literature review of this herb illustrates the wide range of pharmacological activities, including anti-inflammatory activity, antifibrotic action, antispasmodic activity, antioxidant activities, and neuroprotective action, as well as cardio- and cerebrovascular effects[33].

Angelica is also used to treat coldness, numbness, painful joints, soreness and weakness of the low back and knees. Topically, it is used with other herbs to treat sores and abscesses, reduce swelling, expel pus, relieve pain, and heal slow-healing sores. It unblocks the bowels and is used to treat constipation and dry stools. It has also been used to treat arrhythmia, stroke, migraine, nephritis, upper gastrointestinal bleeding, liver disease, bed wetting, uterine prolapse, insomnia, blocked blood vessels in the hands and feet, herpes zoster, alopecia, psoriasis, dermatological disorders, deafness, anal fissure, chronic hypertropic rhinitis, and chronic pharyngitis[34].

Herb – drug interaction: It is suggested that concurrent use of Angelica with wafarin may potentiate the effects of wafarin, anti-platelet, and anticoagulant drugs. This herb reduces scopolamine and cycloheximide induced amnesia in rats. Angelica also treats acetaminophen-induced liver damage[35]. Another herb called Dragon’s blood may also help to relieve pain from elevated Substance P.

Pain Relieving, Anti-Substance P Remedy #5: Dragon’s Blood Herb
This herb has been used for thousands of years for treating various pains for due to its potent anti-inflammatory and analgesic effects. In one study on rat neurons, this herb demonstrated anti-inflammatory and analgesic effects by blocking the synthesis and release of substance P through inhibition of COX-2 protein induction and intracellular calcium ion concentration[36]. In another animal study, Dragon’s Blood active compounds had a synergistic effect on relieving pain in spinal nerve cells[37]. A combination of herb and essential remedies may help with reducing chronic pain caused by elevated levels of Substance P in people with Lyme disease.

These five remedies may help to reduce chronic pain caused by too much Substance P
People with neurological Lyme disease that also have chronic pain may have elevated levels of Substance P. Similar to not getting your finger snapped in a chewing gum prank, a combination of herbal and essential oil remedies may help to reduce the levels of Substance P, inflammatory cytokines, and chronic pain. These remedies may also help with protecting the brain and nervous system against the damaging and inflammatory effects of Substance P. Processing these herbs and essential oils into microparticle remedies, called liposomes, may enhance their ability to penetrate the blood brain barrier, lower levels of Substance P in the central nervous system, and relieve chronic brain and body pain. Since liposomal remedies requires special knowledge and equipment, work with a Lyme / liposomal literate natural remedy practitioner to develop a customized, safe, and effective treatment plan for your condition.

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday April 3rd at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing Lyme disease chronic pain, co-infections, and inflammation symptoms.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to reduce Lyme disease and co-infection chronic pain from elevated levels of Substance P? Tell us about it.


1 “Substance P.” Wikipedia, February 28, 2017. https://en.wikipedia.org/w/index.php
2 Lyon, Pamela, Milton Cohen, and John Quintner. “An Evolutionary Stress-Response Hypothesis for Chronic Widespread Pain (Fibromyalgia Syndrome).” Pain Medicine (Malden, Mass.) 12, no. 8 (August 2011): 1167–78. doi:10.1111/j.1526-4637.2011.01168.x. https://www.ncbi.nlm.nih.gov/pubmed/21692974
3 Jang, M.-U., J.-W. Park, H.-S. Kho, S.-C. Chung, and J.-W. Chung. “Plasma and Saliva Levels of Nerve Growth Factor and Neuropeptides in Chronic Migraine Patients.” Oral Diseases 17, no. 2 (March 2011): 187–93. doi:10.1111/j.1601-0825.2010.01717.x.
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4 Lisowska, Barbara, Aleksander Lisowski, and Katarzyna Siewruk. “Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.” PloS One 10, no. 10 (2015): e0139206. doi:10.1371/journal.pone.0139206.
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5 Wei, Tzuping, Tian-Zhi Guo, Wen-Wu Li, Saiyun Hou, Wade S. Kingery, and John David Clark. “Keratinocyte Expression of Inflammatory Mediators Plays a Crucial Role in Substance P-Induced Acute and Chronic Pain.” Journal of Neuroinflammation 9 (July 23,
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6 Ma, Yong, Zu-Long Wang, Zi-Xue Sun, Bo Men, and Bao-Qing Shen. “[Common TCM syndrome pattern of chronic pelvic pain syndrome relates to plasma substance p and beta endorphin].” Zhonghua Nan Ke Xue = National Journal of Andrology 20, no. 4 (April 2014): 363–66. https://www.ncbi.nlm.nih.gov/pubmed/24873166
7 Karlsson, L., B. Gerdle, B. Ghafouri, E. Bäckryd, P. Olausson, N. Ghafouri, and B. Larsson. “Intramuscular Pain Modulatory Substances before and after Exercise in Women with Chronic Neck Pain.” European Journal of Pain (London, England) 19, no. 8 (September 2015): 1075–85. doi:10.1002/ejp.630.
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8 Jarcho, Johanna M., Natasha A. Feier, Alberto Bert, Jennifer A. Labus, Maunoo Lee, Jean Stains, Bahar Ebrat, et al. “Diminished Neurokinin-1 Receptor Availability in Patients with Two Forms of Chronic Visceral Pain.” Pain 154, no. 7 (July 2013): 987–96.
doi:10.1016/j.pain.2013.02.026. https://www.ncbi.nlm.nih.gov/pubmed/23582152
9 Schroeder, Malte, Lennart Viezens, Christian Schaefer, Barbara Friedrichs, Petra Algenstaedt, Wolfgang Rüther, Lothar Wiesner, and Nils Hansen-Algenstaedt. “Chemokine Profile of Disc Degeneration with Acute or Chronic Pain.” Journal of Neurosurgery. Spine 18, no. 5 (May 2013): 496–503. doi:10.3171/2013.1.SPINE12483.
https://www.ncbi.nlm.nih.gov/pubmed/23473344
10 Öztürk, Niyazi, Nuray Erin, and Serdar Tüzüner. “Changes in Tissue Substance P Levels in Patients with Carpal Tunnel Syndrome.” Neurosurgery 67, no. 6 (December 2010): 1655-1660; discussion 1660-1661. doi:10.1227/NEU.0b013e3181fa7032.
https://www.ncbi.nlm.nih.gov/pubmed/21107196
11 Schwarz, Markus J., and Manfred Ackenheil. “The Role of Substance P in Depression: Therapeutic Implications.” Dialogues in Clinical Neuroscience 4, no. 1 (March 2002): 21–29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181667/
12 Robinson, Prema, Armandina Garza, Joel Weinstock, Jose A. Serpa, Jerry Clay Goodman, Kristian T. Eckols, Bahrom Firozgary, and David J. Tweardy. “Substance P Causes Seizures in Neurocysticercosis.” PLoS Pathogens 8, no. 2 (February 2012):
e1002489. doi:10.1371/journal.ppat.1002489.
https://www.ncbi.nlm.nih.gov/pubmed/22346746
13 Johnson, M. Brittany, Ada D. Young, and Ian Marriott. “The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders.” Frontiers in Cellular Neuroscience 10 (2016): 296. doi:10.3389/fncel.2016.00296.
https://www.ncbi.nlm.nih.gov/pubmed/28101005
14 Muñoz, Miguel, and Rafael Coveñas. “Involvement of Substance P and the NK-1 Receptor in Human Pathology.” Amino Acids 46, no. 7 (July 2014): 1727–50. doi:10.1007/s00726-014-1736-9. https://www.ncbi.nlm.nih.gov/pubmed/24705689
15 Johnson, M. Brittany, Ada D. Young, and Ian Marriott. “The Therapeutic Potential of Targeting Substance P/NK-1R Interactions in Inflammatory CNS Disorders.” Frontiers in Cellular Neuroscience 10 (2016): 296. doi:10.3389/fncel.2016.00296.
http://journal.frontiersin.org/…/fncel.2016.00296/full
16 Rasley, Amy, Ian Marriott, Craig R. Halberstadt, Kenneth L. Bost, and Juan Anguita. “Substance P Augments Borrelia Burgdorferi-Induced Prostaglandin E2 Production by Murine Microglia.” Journal of Immunology (Baltimore, Md.: 1950) 172, no. 9 (May 1,
2004): 5707–13. https://www.ncbi.nlm.nih.gov/pubmed/15100316
17 Martinez, Alejandra N., Geeta Ramesh, Mary B. Jacobs, and Mario T. Philipp. “Antagonist of the Neurokinin-1 Receptor Curbs Neuroinflammation in Ex Vivo and in Vitro Models of Lyme Neuroborreliosis.” Journal of Neuroinflammation 12 (December 30,
2015): 243. doi:10.1186/s12974-015-0453-y.
https://www.ncbi.nlm.nih.gov/pubmed/26714480
18 Schwarz, Markus J., and Manfred Ackenheil. “The Role of Substance P in Depression: Therapeutic Implications.” Dialogues in Clinical Neuroscience 4, no. 1 (March 2002): 21–29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181667/
19 Diemunsch, P., G. P. Joshi, and J.-F. Brichant. “Neurokinin-1 Receptor Antagonists in the Prevention of Postoperative Nausea and Vomiting.” BJA: British Journal of Anaesthesia 103, no. 1 (July 1, 2009): 7–13. doi:10.1093/bja/aep125.
https://academic.oup.com/bja/article/103/1/7/459585/Neurokinin-1-receptor-antagonistsin-the
20 De Luca, Maria Antonietta, Francesco Lai, Francesco Corrias, Pierluigi Caboni, Zisis Bimpisidis, Elias Maccioni, Anna Maria Fadda, and Gaetano Di Chiara. “Lactoferrin- and Antitransferrin-Modified Liposomes for Brain Targeting of the NK3 Receptor Agonist
Senktide: Preparation and in Vivo Evaluation.” International Journal of Pharmaceutics 479, no. 1 (February 1, 2015): 129–37. doi:10.1016/j.ijpharm.2014.12.057.
https://www.ncbi.nlm.nih.gov/pubmed/25560308
21 Franz-Montan, Michelle, André L. R. Silva, Karina Cogo, Cristiane de C. Bergamaschi, Maria C. Volpato, José Ranali, Eneida de Paula, and Francisco C. Groppo. “Liposome-Encapsulated Ropivacaine for Topical Anesthesia of Human Oral Mucosa.” Anesthesia and Analgesia 104, no. 6 (June 2007): 1528–1531, table of contents. doi:10.1213/01.ane.0000262040.19721.26.
https://www.ncbi.nlm.nih.gov/pubmed/17513653
22 Thamphiwatana, Soracha, Weiwei Gao, Marygorret Obonyo, and Liangfang Zhang. “In Vivo Treatment of Helicobacter Pylori Infection with Liposomal Linolenic Acid Reduces Colonization and Ameliorates Inflammation.” Proceedings of the National Academy of Sciences of the United States of America 111, no. 49 (December 9, 2014):
17600–605. doi:10.1073/pnas.1418230111.
https://www.ncbi.nlm.nih.gov/pubmed/25422427
23 Hills, J. M., and P. I. Aaronson. “The Mechanism of Action of Peppermint Oil on Gastrointestinal Smooth Muscle. An Analysis Using Patch Clamp Electrophysiology and Isolated Tissue Pharmacology in Rabbit and Guinea Pig.” Gastroenterology 101, no. 1 (July 1991): 55–65. https://www.ncbi.nlm.nih.gov/pubmed/1646142
24 Göbel, H., G. Schmidt, M. Dworschak, H. Stolze, and D. Heuss. “Essential Plant Oils and Headache Mechanisms.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 2, no. 2 (October 1995): 93–102. doi:10.1016/S0944-7113(11)80053-X.
http://www.sciencedirect.com/…/pii/S094471131180053X
25 “Peppermint Safety Info | National Association for Holistic Aromatherapy.” Accessed April 1, 2017. http://naha.org/naha-blog/peppermint-safety-info/.
26 Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. 2 edition. Edinburgh: Churchill Livingstone, 2013. https://www.amazon.com/Essential-Oil-Safety…/dp/0443062412
27 Zhang, Wei Kevin, Shan-Shan Tao, Ting-Ting Li, Yu-Sang Li, Xiao-Jun Li, He-Bin Tang, Ren-Huai Cong, Fang-Li Ma, and Chu-Jun Wan. “Nutmeg Oil Alleviates Chronic Inflammatory Pain through Inhibition of COX-2 Expression and Substance P Release in Vivo.” Food & Nutrition Research 60 (April 26, 2016). doi:10.3402/fnr.v60.30849.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848392/
28 Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. 2 edition. Edinburgh: Churchill Livingstone, 2013.
29 Khalil, Zeinab, Annette L. Pearce, Narmatha Satkunanathan, Emma Storer, John J. Finlay-Jones, and Prue H. Hart. “Regulation of Wheal and Flare by Tea Tree Oil: Complementary Human and Rodent Studies.” The Journal of Investigative Dermatology 123, no. 4 (October 2004): 683–90. doi:10.1111/j.0022-202X.2004.23407.x.
https://www.ncbi.nlm.nih.gov/pubmed/15373773
30 Khalil, Zeinab, Annette L. Pearce, Narmatha Satkunanathan, Emma Storer, John J. Finlay-Jones, and Prue H. Hart. “Regulation of Wheal and Flare by Tea Tree Oil: Complementary Human and Rodent Studies.” The Journal of Investigative Dermatology 123, no. 4 (October 2004): 683–90. doi:10.1111/j.0022-202X.2004.23407.x.
http://www.jidonline.org/…/S0022-202X(15)30988-X/abstract
31 Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. 2 edition. Edinburgh: Churchill Livingstone, 2013.
32 Lee, Jaehong, You Yeon Choi, Mi Hye Kim, Jae Min Han, Ji Eun Lee, Eun Hye Kim, Jongki Hong, Jinju Kim, and Woong Mo Yang. “Topical Application of Angelica Sinensis Improves Pruritus and Skin Inflammation in Mice with Atopic Dermatitis-Like Symptoms.” Journal of Medicinal Food 19, no. 1 (January 2016): 98–105. doi:10.1089/jmf.2015.3489.
https://www.ncbi.nlm.nih.gov/pubmed/26305727
33 Wei, Wen-Long, Rui Zeng, Cai-Mei Gu, Yan Qu, and Lin-Fang Huang. “Angelica Sinensis in China-A Review of Botanical Profile, Ethnopharmacology, Phytochemistry and Chemical Analysis.” Journal of Ethnopharmacology 190 (August 22, 2016): 116–41. doi:10.1016/j.jep.2016.05.023. https://www.ncbi.nlm.nih.gov/pubmed/27211015
34 Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and
Pharmacology. City of Industry CA: Art of Medicine Press, Inc., pp. 918 – 924.
35 Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and
Pharmacology. City of Industry CA: Art of Medicine Press, Inc., pp. 918 – 924.
36 Li, Yu-Sang, Jun-Xian Wang, Mei-Mei Jia, Min Liu, Xiao-Jun Li, and He-Bin Tang. “Dragon’s Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats.” Journal of Pharmacological Sciences 118, no. 1 (2012): 43–54.
https://www.ncbi.nlm.nih.gov/pubmed/22198006
37 Guo, Min, Su Chen, and Xiangming Liu. “Material Basis for Inhibition of Dragon’s Blood on Evoked Discharges of Wide Dynamic Range Neurons in Spinal Dorsal Horn of Rats.” Science in China. Series C, Life Sciences 51, no. 11 (November 2008): 1025–38. doi:10.1007/s11427-008-0133-6. https://www.ncbi.nlm.nih.gov/pubmed/18989646


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Mar 4 17

Five Treatments for Stopping Runaway Mast Cell Inflammation Caused by Lyme, Parasites, and Mold

by Greg

For people with severe allergies and swollen tissues who have been diagnosed with Lyme, mold, or parasitic infections
by Greg Lee
Have you ever washed a car with a giggly little girl? One warm day, my daughter and I got out the big sponges and soaped up the car. She did the lower half and I did the upper. Her giggly side came out when she got to rinse off the car. Small girl + hose + giggles = spray daddy! She chased me around the car laughing and spraying me from top to bottom. I’m sure I got rinsed more than the car.

How is being drenched by a little kid with a hose similar to excess mast cell inflammation caused by an underlying Lyme disease, parasitic, or mold infection?

Similar to being totally soaked by a giggly little girl and a garden hose, many infections can trigger a flood of excess mast cell inflammation
Multiple infections can trigger mast cells to release a large amount of inflammatory compounds. In animal studies, Lyme disease1, parasitic helminths, nematodes, protozoa including Malaria, mold including Aspergillus fumigatus hyphae, bacterial infections including Klebsiella pneumoniae, Mycoplasma pneumoniae; Pseudomonas aeruginosa, group A streptococcal (GAS) skin infection, and E. coli peritoneal and urinary infections, Haemophilus influenzae otitis media; and polymicrobial intra-abdominal sepsis can trigger mast cells to quickly release inflammatory compounds2. In human and animal studies, viral infections including Dengue3, H1N54, Herpes5, and respiratory syncytial virus6 are also capable of triggering the release of mast cell inflammation. Mast cells are an initial line of defense against invading pathogens.

Mast cells inflammation is a normal immune system response to invading pathogens
Mast cells are white blood cells that have the ability to trigger the release of infection fighting inflammatory compounds upon invading germs. These cells are are found in most tissues of the body. Immature mast cells circulate through the blood and implant in tissues with a vascular blood supply. They are particularly concentrated in the tissues exposed to the outside environment: skin, airways and intestines, which are perfect for detecting an incoming invader. These cells are also effective at keeping many infections in check.

Mast cells may also help to suppress certain infections
In mouse experiments, mast cells mediate the expulsion of parasite worms: Trichinella spiralis and Strongyloides. Moreover, mast cell–deficient mice develop larger number of parasites and larger lesions in a Leishmania major infection7. Mast cells decrease the uptake and growth of pulmonary tularemia in macrophages in another mouse study8. Unfortunately in chronic infection patients, mast cells can be hyper-activated which results in the over-production of inflammatory compounds.

Mast cell activation syndrome (MCAS) is defined as the excess over production of mast cell inflammation
Mast cell activation syndrome has been known to produce a wide range of chronic symptoms in patients with mold exposure9, Lyme disease10, recurrent infections and low antibody levels, specifically in immunoglobulin (Ig) types IgG, IgM and IgA. Symptoms often include new infections, chronic lung disease, and inflammation and infection of the gastrointestinal tract11, Ehlers–Danlos syndrome (EDS) and postural orthostatic tachycardia syndrome (POTS)12. Different systems in the body may present with these MCAS symptoms13 including:

  • Dermatological: flushing, easy bruising, either a reddish or a pale complexion, itchiness
  • Cardiovascular: lightheadedness, dizziness, presyncope, syncope
  • Gastrointestinal: diarrhea, cramping, intestinal discomfort, nausea, vomiting, small intestine bacterial overgrowth (SIBO)
  • Swallowing, throat tightness
  • Psychological & Neurological: brain fog, short term memory dysfunction, difficulty with recalling words, headaches, migraines
  • Respiratory: congestion, coughing, wheezing
  • Vision/Eyes: ocular discomfort, conjunctivitis
  • Constitutional: general fatigue and malaise, food, drug, and chemical intolerances especially fragrances, sense of being cold all the time
  • Musculoskeletal: osteoporosis and osteopenia including young patients
  • Rapid weight gain, obesity, diabetes
  • Anaphylaxis especially if too many inflammatory compounds are dumped suddenly into a patient’s system, difficulty breathing, itchy hives, flushing or pale skin, feeling of warmth, weak and rapid pulse, nausea, vomiting, diarrhea, dizziness and fainting

Symptoms can be caused by or worsened by triggers, which vary widely and are patient-specific. Common triggers include: alcohol, and high-histamine content foods, temperature extremes, airborne smells including perfumes or smoke, exercise or exertion, emotional stress, hormonal changes – particularly during adolescence, pregnancy and women’s menstrual cycles. These symptoms are thought to be caused be genetic issues and are therefore incurable. Since mast cells are widespread throughout the body, symptoms can also occur in virtually all organs and tissues. Moreover, symptoms can flare up from time to time, waxing and waning over years to decades14. Specific inflammatory markers have been found in MCAS patients.

Specific inflammatory compounds have been identified in mast cell activation patients
Many different inflammatory compounds can be produced and released by mast cells. These compounds have been identified as markers in patients with MCAS: Beta-Tryptase15, histamine, heparin, proteases and cytokines such as Tumor Necrosis Factor alpha (TNF-α), arachidonic acid metabolites PGD2 and LTC416, and a number of other cytokines/growth factors and chemokines including Interleukin-5 (IL-5), Interleukin-6 (IL-6), Interleukin-13 (IL-13), Interleukin-16 (IL-16), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), nerve growth factor (NGF), basic fibroblast growth factor (bFGF) and Vascular endothelial growth factor (VEGF), as well as several C-C chemokines17. Medications can help with managing MCAS symptoms.

Medications can help with reducing inflammatory compounds from mast cell activation
There have not been any therapeutic trials of medications for MCAS. Medications that have been effective have been used in animal studies, individuals, or small group human case studies. Due to the wide variance in patient symptoms, triggers, genetic and epigenetic factors, highly individualized treatment is necessary18. Anti-allergy drugs reduced mast cell inflammation in mice19, antihistamine drugs, immunosuppresive medications, kinase inhibitors, chemotherapy drugs, and in rare cases stem cell therapy have had varying success in reducing symptoms in MCAS patients20.

What else can help you to reduce runaway inflammation caused by mast cell activation?

Here are five treatments for reducing excess mast cell inflammation
Inhibiting mast cell inflammation production may help to stop chronic MCAS. Formulating remedies into microparticles called liposomes has been effective at mediating mast cell activation21. Liposomal remedies have also been effective at reducing the production of inflammatory cytokines IL-6 and TNF-α22 in a mouse study. Liposomal remedies also have been shown to penetrate deeper into host cells23 and into pathogens24 than their non-liposomal counterparts. Fortunately, liposomal encapsulation and delivery of essential oils, herbs, and supplements may increase their penetration and effectiveness against mast cell activation syndrome inflammation.

Reducing Mast Cell Inflammation Treatment #1: Essential Oils
Lavender oil inhibits mast cell inflammation in mice and rats and TNF-α production25. A 2:1 combination of essential oils of Lavender and Thyme reduced mast cell degranulation and inflammation when applied for twenty-one days in a mouse study26. German chamomile oil was highly effective at inhibiting mast cell degranulation in a lab study27 and a rat study28. Geranium essential oil inhibited cultured mast cell degranulation in another rat study29. Not only essential oils, but also herbs have been effective at inhibiting mast cell inflammation.

Reducing Mast Cell Inflammation Treatment #2: Herbs
Compounds in salvia miltiorrhiza root, Chinese name Dan Shen, blunt mast cell degranulation in a lab study30. Sanguisorbia root, Chinese name: Di Yu, inhibited mast cell degranulation, Interferon-gamma (INF-γ) and TNF-α production in a lab study31. Houttuynia, Chinese name: Yu Xing Cao, blocked the mast cell inflammatory production of TNF-α, IL-6, IL-8 and nuclear factor kappa-B (NF-kB) in a lab experiment32. Magnolia flower, Chinese name: Xin Yi Hua, has been effective in inhibiting mast cell histamine release33. Agaricus mushroom, Chinese name: Ji Song Rong, inhibits the mast cell anaphylactic shock reaction in a rat study34. Supplements can also help with mast cell inflammation.

Reducing Mast Cell Inflammation Treatment #3: Natural supplements
Curcumin, the main compound in turmeric, inhibits the release of inflammation from mast cells35. Alpha lipoic acid decreased mast cell histamine release and the anaphylactic shock reaction in a lab study36. Quercetin has also been effective in blocking the release of mast cell histamine and inflammatory cytokines Il-8, TNF, and NF-kB37. Theanine inhibited the mast cell production of histamines, TNF-α, IL-1β, IL-6, and IL-8 secretion by suppressing NF-κB activation in a lab study38. In addition to supplements, electro-acupuncture has shown to be effective at reducing mast cell inflammation.

Reducing Mast Cell Inflammation Treatment #4: Electro-acupuncture
In one rat study, electro-acupuncture on acupoint Stomach-25 inhibited the activation of Substance-P and VIP in mast cells39. Frequency Specific Microcurrent can also help with reducing histamine and inflammatory compounds.

Reducing Mast Cell Inflammation Treatment #5: Frequency Specific Microcurrent
Frequency Specific Microcurrent uses very low level electrical currents to reduce histamines, inflammatory compounds, and bacterial, fungal and parasitic infections and toxins40. These currents are combined with a second set of frequencies to target inflamed or toxic areas. As a result, allergic symptoms and inflamed areas can be dramatically reduced. A combination of remedies and treatments can help with reducing mast cell activation symptoms.

These five treatments may help to reduce excess histamines and inflammation from mast cell activation syndrome
People with Lyme disease, mold or parasites that have allergic sensitivity due to excess histamines, way too much inflammation, and symptoms that are not improving with Lyme medications may have a condition called mast cell activation syndrome. Just like redirecting a girl to rinse the car instead of soaking her dad, remedies and treatments may help to reduce the overproduction of histamine, inflammatory cytokines and persistent symptoms of mast cell activation. Processing herbs, essential oils, and supplements into microparticle remedies, called liposomes, may help them to be more effective at reducing mast cell inflammation symptoms. Since liposomal remedies requires special knowledge and equipment, work with a Lyme / liposomal literate natural remedy practitioner to develop a customized, safe, and effective treatment plan for your condition.

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday March 6th at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing Lyme disease, co-infection, and mast cell inflammation symptoms.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to reduce allergic reactions and inflammation due to Lyme induced mast cell activation? Tell us about it.


1 Talkington, Jeffrey, and Steven P. Nickell. “Borrelia Burgdorferi Spirochetes Induce Mast Cell Activation and Cytokine Release.” Infection and Immunity 67, no. 3 (March 1999): 1107–15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96436/
2 Urb, Mirjam, and Donald C. Sheppard. “The Role of Mast Cells in the Defence against Pathogens.” PLOS Pathogens 8, no. 4 (April 26, 2012): e1002619. doi:10.1371/journal.ppat.1002619.
http://journals.plos.org/plospathogens/article? id=10.1371/journal.ppat.1002619
3 Chu, Ya-Ting, Shu-Wen Wan, Robert Anderson, and Yee-Shin Lin. “Mast Cell-Macrophage Dynamics in Modulation of Dengue Virus Infection in Skin.” Immunology 146, no. 1 (September 2015): 163–72. doi:10.1111/imm.12492. https://www.ncbi.nlm.nih.gov/pubmed/26059780
4 Hu, Yanxin, Yi Jin, Deping Han, Guozhong Zhang, Shanping Cao, Jingjing Xie, Jia Xue, et al. “Mast Cell-Induced Lung Injury in Mice Infected with H5N1 Influenza Virus.” Journal of Virology 86, no. 6 (March 2012): 3347–56. doi:10.1128/JVI.06053-11.
https://www.ncbi.nlm.nih.gov/pubmed/22238293
5 Larocca, R. D. “Eosinophilic Conjunctivitis, Herpes Virus and Mast Cell Tumor of the Third Eyelid in a Cat.” Veterinary Ophthalmology 3, no. 4 (2000): 221–25. https://www.ncbi.nlm.nih.gov/pubmed/11397307
6 Shirato, Kazuya, and Fumihiro Taguchi. “Mast Cell Degranulation Is Induced by A549 Airway Epithelial Cell Infected with Respiratory Syncytial Virus.” Virology 386, no. 1 (March 30, 2009): 88–93. doi:10.1016/j.virol.2009.01.011.
https://www.ncbi.nlm.nih.gov/pubmed/19195674
7 Urb, Mirjam, and Donald C. Sheppard. “The Role of Mast Cells in the Defence against Pathogens.” PLOS Pathogens 8, no. 4 (April 26, 2012): e1002619. doi:10.1371/journal.ppat.1002619.
http://journals.plos.org/plospathogens/article…
8 Ketavarapu, Jyothi M., Annette R. Rodriguez, Jieh-Juen Yu, Yu Cong, Ashlesh K. Murthy, Thomas G. Forsthuber, M. Neal Guentzel, Karl E. Klose, Michael T. Berton, and Bernard P. Arulanandam. “Mast Cells Inhibit Intramacrophage Francisella Tularensis
Replication via Contact and Secreted Products Including IL-4.” Proceedings of the National Academy of Sciences of the United States of America 105, no. 27 (July 8, 2008): 9313–18. doi:10.1073/pnas.0707636105.
https://www.ncbi.nlm.nih.gov/pubmed/18591675
9 Theoharides, Theoharis C., Julia M. Stewart, Erifili Hatziagelaki, and Gerasimos Kolaitis. “Brain ‘fog,’ Inflammation and Obesity: Key Aspects of Neuropsychiatric Disorders Improved by Luteolin.” Frontiers in Neuroscience 9 (July 3, 2015). doi:10.3389/fnins.2015.00225. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490655/
10 Talkington, Jeffrey, and Steven P. Nickell. “Borrelia Burgdorferi Spirochetes Induce Mast Cell Activation and Cytokine Release.” Infection and Immunity 67, no. 3 (March 1999): 1107–15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96436/
11 “Common Variable Immunodeficiency.” Wikipedia, September 25, 2016. https://en.wikipedia.org/w/index.php title=Common_variable_immunodeficiency&oldid=741130072. https://en.wikipedia.org/…/Common_variable…
12 “Mast Cell Activation Syndrome.” Wikipedia, November 25, 2016.
https://en.wikipedia.org/w/index.php? title=Mast_cell_activation_syndrome&oldid=751436907.
13 “Mast Cell Activation Syndrome.” Wikipedia, November 25, 2016.
https://en.wikipedia.org/w/index.php…. https://en.wikipedia.org/wiki/Mast_cell_activation_syndrome
14 Molderings, Gerhard J, Stefan Brettner, Jürgen Homann, and Lawrence B Afrin. “Mast Cell Activation Disease: A Concise Practical Guide for Diagnostic Workup and Therapeutic Options.” Journal of Hematology & Oncology 4 (March 22, 2011): 10. doi:10.1186/1756-8722-4-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069946/
15 Payne, V., and P. C. A. Kam. “Mast Cell Tryptase: A Review of Its Physiology and Clinical Significance.” Anaesthesia 59, no. 7 (July 2004): 695–703. doi:10.1111/j.1365- 2044.2004.03757.x. https://www.ncbi.nlm.nih.gov/pubmed/15200544
16 Akin, Cem, Peter Valent, and Dean D. Metcalfe. “Mast Cell Activation Syndrome: Proposed Diagnostic Criteria.” The Journal of Allergy and Clinical Immunology 126, no. 6 (December 2010): 1099–104.e4. doi:10.1016/j.jaci.2010.08.035.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753019/
17 Metcalfe, Dean D. “Mast Cells and Mastocytosis.” Blood 112, no. 4 (August 15, 2008): 946–56. doi:10.1182/blood-2007-11-078097.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515131/
18 Molderings, Gerhard J., Britta Haenisch, Stefan Brettner, Jürgen Homann, Markus Menzen, Franz Ludwig Dumoulin, Jens Panse, Joseph Butterfield, and Lawrence B. Afrin. “Pharmacological Treatment Options for Mast Cell Activation Disease.” Naunyn-
Schmiedeberg’s Archives of Pharmacology 389 (2016): 671–94. doi:10.1007/s00210-016-1247-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110/
19 Wang, Jing, and Guo-Ping Shi. “Mast Cell Stabilization: Novel Medication for Obesity and Diabetes.” Diabetes/Metabolism Research and Reviews 27, no. 8 (November 2011): 919–24. doi:10.1002/dmrr.1272.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318912/
20 Molderings, Gerhard J., Britta Haenisch, Stefan Brettner, Jürgen Homann, Markus Menzen, Franz Ludwig Dumoulin, Jens Panse, Joseph Butterfield, and Lawrence B. Afrin. “Pharmacological Treatment Options for Mast Cell Activation Disease.” Naunyn-
Schmiedeberg’s Archives of Pharmacology 389 (2016): 671–94. doi:10.1007/s00210-016-1247-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110/
21 Inoh, Yoshikazu, Satoshi Tadokoro, Hiroki Tanabe, Makoto Inoue, Naohide Hirashima, Mamoru Nakanishi, and Tadahide Furuno. “Inhibitory Effects of a Cationic Liposome on Allergic Reaction Mediated by Mast Cell Activation.” Biochemical
Pharmacology, 2013. http://agris.fao.org/agrissearch/
search.do?recordID=US201500023163. http://agris.fao.org/agrissearch/search.do…
22 Thamphiwatana, Soracha, Weiwei Gao, Marygorret Obonyo, and Liangfang Zhang. “In Vivo Treatment of Helicobacter Pylori Infection with Liposomal Linolenic Acid Reduces Colonization and Ameliorates Inflammation.” Proceedings of the National Academy of Sciences of the United States of America 111, no. 49 (December 9, 2014):
17600–605. doi:10.1073/pnas.1418230111.
https://www.ncbi.nlm.nih.gov/pubmed/25422427
23 Deno, Sho, Naohiro Takemoto, and Hiroo Iwata. “Introduction of Antioxidant-Loaded Liposomes into Endothelial Cell Surfaces through DNA Hybridization.” Bioorganic & Medicinal Chemistry 22, no. 1 (January 1, 2014): 350–57. doi:10.1016/j.bmc.2013.11.023. https://www.ncbi.nlm.nih.gov/pubmed/24345482
24 Mugabe, Clement, Majed Halwani, Ali O. Azghani, Robert M. Lafrenie, and Abdelwahab Omri. “Mechanism of Enhanced Activity of Liposome-Entrapped Aminoglycosides against Resistant Strains of Pseudomonas Aeruginosa.” Antimicrobial Agents and Chemotherapy 50, no. 6 (June 1, 2006): 2016–22. doi:10.1128/AAC.01547-
05. http://aac.asm.org/content/50/6/2016.full
25 Kim, H. M., and S. H. Cho. “Lavender Oil Inhibits Immediate-Type Allergic Reaction in Mice and Rats.” The Journal of Pharmacy and Pharmacology 51, no. 2 (February 1999): 221–26. https://www.ncbi.nlm.nih.gov/pubmed/10217323
26 Seo, Young Mi, and Seok Hee Jeong. “[Effects of Blending Oil of Lavender and Thyme on Oxidative Stress, Immunity, and Skin Condition in Atopic Dermatitis Induced Mice].” Journal of Korean Academy of Nursing 45, no. 3 (June 2015): 367–77. doi:10.4040/jkan.2015.45.3.367.
https://synapse.koreamed.org/DOIx.php…
27 Mitoshi, Mai, Isoko Kuriyama, Hiroto Nakayama, Hironari Miyazato, Keiichiro Sugimoto, Yuko Kobayashi, Tomoko Jippo, Kazuki Kanazawa, Hiromi Yoshida, and Yoshiyuki Mizushina. “Effects of Essential Oils from Herbal Plants and Citrus Fruits on DNA Polymerase Inhibitory, Cancer Cell Growth Inhibitory, Antiallergic, and Antioxidant Activities.” Journal of Agricultural and Food Chemistry 60, no. 45 (November 14, 2012): 11343–50. doi:10.1021/jf303377f. https://www.ncbi.nlm.nih.gov/pubmed/23088772
28 Miller, T., U. Wittstock, U. Lindequist, and E. Teuscher. “Effects of Some Components of the Essential Oil of Chamomile, Chamomilla Recutita, on Histamine Release from Rat Mast Cells.” Planta Medica 62, no. 1 (February 1996): 60–61. doi:10.1055/s-2006-
957799. https://www.ncbi.nlm.nih.gov/pubmed/8720389
29 Kobayashi, Yuko, Harumi Sato, Mika Yorita, Hiroto Nakayama, Hironari Miyazato, Keiichiro Sugimoto, and Tomoko Jippo. “Inhibitory Effects of Geranium Essential Oil and Its Major Component, Citronellol, on Degranulation and Cytokine Production by Mast
Cells.” Bioscience, Biotechnology, and Biochemistry 80, no. 6 (June 2016): 1172–78. doi:10.1080/09168451.2016.1148573. https://www.ncbi.nlm.nih.gov/pubmed/26927807
30 Han, Jing-Yan, Jing-Yu Fan, Yoshinori Horie, Soichiro Miura, De-Hua Cui, Hiromasa Ishii, Toshifumi Hibi, Hiroshi Tsuneki, and Ikuko Kimura. “Ameliorating Effects of Compounds Derived from Salvia Miltiorrhiza Root Extract on Microcirculatory Disturbance and Target Organ Injury by Ischemia and Reperfusion.” Pharmacology &
Therapeutics 117, no. 2 (February 2008): 280–95.
doi:10.1016/j.pharmthera.2007.09.008. https://www.ncbi.nlm.nih.gov/pubmed/18048101
31 Yang, Ju-Hye, Jae-Myung Yoo, Won-Kyung Cho, and Jin Yeul Ma. “Anti-Inflammatory Effects of Sanguisorbae Radix Water Extract on the Suppression of Mast Cell Degranulation and STAT-1/Jak-2 Activation in BMMCs and HaCaT Keratinocytes.” BMC
Complementary and Alternative Medicine 16 (September 6, 2016): 347. doi:10.1186/s12906-016-1317-4. https://www.ncbi.nlm.nih.gov/pubmed/27599590
32 Lee, Hee Joe, Hye-Sook Seo, Gyung-Jun Kim, Chan Yong Jeon, Jong Hyeong Park, Bo-Hyoung Jang, Sun-Ju Park, Yong-Cheol Shin, and Seong-Gyu Ko. “Houttuynia Cordata Thunb Inhibits the Production of pro-Inflammatory Cytokines through Inhibition
of the NFκB Signaling Pathway in HMC-1 Human Mast Cells.” Molecular Medicine Reports 8, no. 3 (September 2013): 731–36. doi:10.3892/mmr.2013.1585.
https://www.ncbi.nlm.nih.gov/pubmed/23846481
33 Shen, Y., E. C. K. Pang, C. C. L. Xue, Z. Z. Zhao, J. G. Lin, and C. G. Li. “Inhibitions of Mast Cell-Derived Histamine Release by Different Flos Magnoliae Species in Rat Peritoneal Mast Cells.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 15, no. 10 (October 2008): 808–14. doi:10.1016/j.phymed.2008.04.012. https://www.ncbi.nlm.nih.gov/pubmed/18585022
34 Choi, Yun Ho, Guang Hai Yan, Ok Hee Chai, Yung Hyun Choi, Xin Zhang, Jung Min Lim, Ji-Hyun Kim, et al. “Inhibitory Effects of Agaricus Blazei on Mast Cell-Mediated Anaphylaxis-like Reactions.” Biological & Pharmaceutical Bulletin 29, no. 7 (July 2006):
1366–71.
35 Kurup, Viswanath P., and Christy S. Barrios. “Immunomodulatory Effects of Curcumin in Allergy.” Molecular Nutrition & Food Research 52, no. 9 (September 2008): 1031–39. doi:10.1002/mnfr.200700293. https://www.ncbi.nlm.nih.gov/pubmed/18398870
36 Choi, Yun Ho, Ok Hee Chai, Eui-Hyeog Han, Su-Young Choi, Hyoung Tae Kim, and Chang Ho Song. “Lipoic Acid Suppresses Compound 48/80-Induced Anaphylaxis-like Reaction.” Anatomy & Cell Biology 43, no. 4 (December 2010): 317–24. doi:10.5115/acb.2010.43.4.317.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026184/
37 Weng, Zuyi, Bodi Zhang, Shahrzad Asadi, Nikolaos Sismanopoulos, Alan Butcher, Xueyan Fu, Alexandra Katsarou-Katsari, Christina Antoniou, and Theoharis C. Theoharides. “Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans.” PLOS ONE 7, no. 3 (March 28, 2012): e33805. doi:10.1371/journal.pone.0033805.
https://www.ncbi.nlm.nih.gov/pubmed/22470478
38 Kim, N. H., H. J. Jeong, and H. M. Kim. “Theanine Is a Candidate Amino Acid for Pharmacological Stabilization of Mast Cells.” Amino Acids 42, no. 5 (May 2012): 1609– 18. doi:10.1007/s00726-011-0847-9. https://www.ncbi.nlm.nih.gov/pubmed/21344174
39 Wu, Huan-Gan, Bin Jiang, En-Hua Zhou, Zheng Shi, Da-Ren Shi, Yun-Hua Cui, Suo-Tang Kou, and Hui-Rong Liu. “Regulatory Mechanism of Electroacupuncture in Irritable Bowel Syndrome: Preventing MC Activation and Decreasing SP VIP Secretion.”
Digestive Diseases and Sciences 53, no. 6 (June 2008): 1644–51. doi:10.1007/s10620-007-0062-4. https://www.ncbi.nlm.nih.gov/pubmed/17999187
40 DC, Carolyn McMakin MA. Frequency Specific Microcurrent in Pain Management, 1e. 1 Pap/Dvdr edition. Edinburgh ; New York: Churchill Livingstone, 2011.

DISCLAIMER:-

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-practitioner relationship, and should not be used as a substitute for professional diagnosis and treatment.

Please consult your health care provider, or contact the Two Frogs Healing Center for an appointment, before making any healthcare decisions or for guidance about a specific medical condition. The Two Frogs Healing Center expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. The Two Frogs Healing Center does not endorse specifically any test, treatment, or procedure mentioned on the site.

By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by the Two Frogs Healing Center. If you do not agree to the foregoing terms and conditions, you should not enter this site.

Jan 3 17

Two Frogs Has Moved to a New Office as of January 1st!

by Greg

moving_van

Two Frogs has moved into a larger office!

We are open at our new location inside the:

Frederick Innovative Technology Center (FITCI) at
4539 Metropolitan Court
Frederick, MD 21704

fitci_front

 

There are multiple visitor spaces (highlighted in yellow) across from the front entrance of the FITCI.
If all the visitor spaces are taken, you can park in any open parking space.

 

fitci_above

Here is what the lobby looks like:

fitci_lobby

Have a seat in the waiting area.

Tell the receptionist you are here to see Greg Lee.
Restrooms are right behind the reception desk.
Water is available upon request.

Question? Call us at 301-228-3764 or email at TwoFrogsHealingCenter@gmail.com.
We look forward to seeing you in our new space!

Thanks,

Greg

Oct 19 16

How These Essential Oils Help People with Lyme Disease to Fight Drug Resistant Candida

by Greg

english_ivy

For people receiving antibiotic treatment for Lyme disease that have impaired brain function, fatigue, and intestinal bloating due to a drug-resistant Candida infection
by Greg Lee

While clearing space for a new flower garden, I found a tangled mass of vines. English ivy had overgrown a large area. Pulling up one vine unearthed four more. After thirty minutes of pulling and digging, most of the vines were cleaned up.

How is a tangled mass of ivy similar to a person with Lyme disease that is fighting a Candida infection?

Just like a bed of fast growing ivy, Candida can quickly spread in patients receiving antibiotics for Lyme disease
There are over twenty species of Candida that can infect humans1. Candida is a yeast that can be ingested on contaminated food. Candida can normally be found along with healthy microbes in the digestion tract. Both exposure to environmental mold which suppresses the immune system and excess consumption of alcohol, sugar, and carbohydrates can increase the growth of Candida. People who have chronic medical conditions, like Lyme disease, are a greater risk of a systemic Candida infection2. Antibiotic therapy for Lyme disease, can kill off healthy gut microbes, which can create more areas in the intestines for Candida to spread into. In some cases, antibiotic therapy in Lyme patients may be combined with steroid3 or immuno-suppressive4 treatment. Studies have shown that people undergoing antibiotic, steroid, or immuno-suppressive treatment are more at risk of a Candida infection5. A chronic Lyme infection can also suppress the immune system, which may also enable Candida to spread deeper6. A systemic Candida infection can mimic the symptoms of Lyme disease.

There is a significant overlap between symptoms of a systemic Candida and Lyme disease infection
A systemic Candida infection can produce similar symptoms as found in patients with Lyme disease. Symptoms which overlap are:

  • Fever and chills7
  • Chronic fatigue8
  • Digestion pain, bloating, and nausea9
  • Meningitis10
  • Headache11
  • Arthritis12
  • Heart arrhythmia13
  • Cognitive decline and memory recall problems14
  • ADHD15
  • Depression16
  • Urinary tract infections17
  • Systemic inflammatory response18
  • Seizures19
  • Death20

Not surprisingly, both Lyme and Candida can trigger the release of similar inflammatory compounds which are associated with increased symptoms.

Both Lyme and Candida infections can trigger the increase of multiple inflammatory compounds
Candida21 and Lyme disease22 infections have been shown to trigger the release of Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8)23, and Interleukin-10 (IL-10)24. IL-1β is implicated in patients with depression25 and joint inflammation26. IL-6 is strongly associated with rheumatoid arthritis27, depression28, hostility29, fatigue30, flu-like symptoms and fever31, and cognitive impairment32. IL-8 is implicated in patients with anxiety33, meningitis34, and spirochete (leptospira) induced liver inflammation35. IL-10 is associated with irritable bowel disease36 and fatigue37. Unfortunately, these infections also employ other mechanisms to help them survive in their hosts.

Candida and Lyme employ multiple mechanisms to survive longer
Both infections are capable of hiding inside of cells38, and infecting the brain39. They can producing biofilms40, which are a slime produced to protect against antimicrobial drugs41, the killer cells of the immune system, and against other pathogens. Biofilms can increase drug resistance by a factor of ten to a thousand fold42. Biofilms are believed to be a main cause of recurring Candida or Lyme disease symptoms that persist despite multiple rounds of antibiotics43 or antifungal medications44. In addition to increased resistance from biofilms, Candida has also developed intrinsic and acquired resistance to multiple antifungal drugs45. In addition to biofilms, Lyme bacteria and Candida are capable of producing proteins that lower the activation of the complement immune response46. The complement immune system is a primary coordinator of the innate and adaptive immune responses for killing invading pathogens47.

What else can help people with Lyme disease to fight a drug-resistant, biofilm forming, immune system manipulating, systemic Candida infection?

Here are four essential oils that are effective at inhibiting stubborn Candida infections
Fortunately, there are essential oils that have been found to inhibit drug resistant Candida, cut through biofilms, and enhance the immune response to invading infections. Some of these oils also help with reducing inflammatory compounds that are elevated in a Lyme and Candida infection. Preparing the remedies in a micronized form called a liposome increases their antimicrobial and antibiofilm properties. High dose liposomal antifungal medications have been safe and effective at treating systemic Candida infections in premature infants48. Since liposomes are so small and are surrounded by a lipid, they have a greater ability to penetrate into cells where these infections can hide. Which is why liposomal remedies may be highly effective at helping patients with eliminating a resistant Candida infection.

Anti-Candida Essential Oil #1: Eucalyptus Essential Oil
In multiple lab studies, eucalyptus essential oil was highly effective at inhibiting the growth of fluconazole resistant Candida biofilms49, inhibited the growth of hospital acquired drug resistant strains of Candida50 and inducing innate cell mediated immune response against infections51. In other studies, eucalyptus oil was effective in relieving post-operative pain52 and inhibiting nitric oxide inflammatory production53. In addition to eucalyptus oil, cinnamon has excellent anti-Candida properties.

Anti-Candida Essential Oil #2: Cinnamon Bark Essential Oil
In multiple studies, cinnamon essential oil is effective at inhibiting Candida albicans54, Candida biofilms55, hospital acquired strains of Candida56, respiratory tract Candida57, and fluconazole-resistant Candida58. When combined in a capsule with patchouli essential oil, 71% of patients infected with an intestinal infection of multiple species of Candida were cured59. Liposomal cinnamon oil was effective at inhibiting drug resistant staphylococcus and it’s biofilms60. Cinnamon oil was effective in lab studies at inhibiting these inflammatory compounds: neurological inducible nitric oxide synthase (iNOS), Cyclooxygenase-2 (COX-2) expression, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inflammation61. Caution: cinnamon oil has produced allergic dermatitis in some cases when placed on the skin. This oil may interfere with blood clotting. In one case, a boy drank 60 ml of cinnamon oil upon a dare and experienced symptoms of burning sensation in the mouth, chest and stomach, dizziness, double vision, nausea, vomiting and later collapsed62. Another promising anti-Candida essential oil is lemongrass.

Anti-Candida Essential Oil #3: Lemongrass Essential Oil
Vaporized Lemongrass oil was 100% effective at inhibiting Candida albicans in a lab study63. In other studies, lemongrass essential oil inhibited multi-drug resistant Candida albicans64, multi-drug resistant strains of Streptococcus and Candida65, and multiple species of Candida66. Lemongrass essential oil has an enhanced killing effect against two species of Candida when combined with silver ions67. Lemongrass oil followed by clove oil was highly effective against Candida albicans and its biofilms68. In one lab study, lemongrass oil inhibited the production of IL-1beta and IL-669. In a human study, lemongrass oil reduced anxiety and tension70. Another spice oil with anti-Candida properties is oregano.

Anti-Candida Essential Oil #4: Oregano Essential Oil
In multiple studies, oregano essential oil was highly effective at inhibiting multiple drug resistant species of Candida71, stopping germination and mycelial growth of Candida albicans in a dose dependent manner72, and inducing cell wall and membrane damage in thirty different strains of Candida albicans73. Oregano oil inhibited IL-1beta, IL-6, GM-CSF, and TNF-alpha inflammatory compounds in a mouse experiment74. Using multiple essential oils in combination can help with reducing systemic Candida infection symptoms and inflammation.

Essential oils in combination can help to resolve systemic Candida infection symptoms in people with Lyme
Similar to clearing out a tangled mass of ivy, essential oils can help people with Lyme to weed out systemic Candida symptoms. Combining these oils together may enhance their anti-Candia and anti-biofilm properties. Patients that have taken these oils combined with a carrier oil under their tongue have reported reduced symptoms of inflammation, improved sleep, and less brain fog.

When encapsulated into a micronized particle called a liposome, these oils may be capable of even greater penetration into the cells, nervous system, and into biofilms where Candida can hide. Through inhibiting the production of inflammatory compounds, these oils may also help with relieving physical symptoms and uncomfortable emotions that are associated with Candida toxins and inflammation. Since some of these essential oils have cautions on their use, work with a Lyme literate essential oil practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday November 7th at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing Lyme disease, co-infection, and Candida symptoms.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to clear a resistant Candida infection? Tell us about it.


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Jul 29 16

How These Four Herbs Help to Stop Bartonella Rage and Obsessive Compulsive Disorder (OCD)

by Greg

For people who have been diagnosed with Bartonella that have severe anger and obsessive compulsive behaviors
by Greg Lee

A few months ago I got a surprise call from my credit card provider who asked if I had made a recent $900 purchase from a clothing store in New York. I told them that I didn’t. They also asked about other charges made in shops and restaurants in the same area. Somehow my credit card number was stolen and being used. Several charges had accumulated in a short period of time before the card was canceled.

How is a thief that buys stuff on your credit card just like anger and obsessive behaviors caused by a Bartonella infection?

Just like fraudulent credit card charges that are made without your knowledge, Bartonella can quietly infect organs and tissues throughout the body

Bartonella is a Gram-negative bacterial infection that can be transmitted by insect bites, including fleas, lice, sand flies[1], flea feces,[2] mites[3], and possibly by ticks[4], spiders[5], or bed bugs[6]. This infection may also be transmitted by infected animal bites[7], scratches[8], or possibly by blood transfusion[9] or organ transplant[10].  There are over thirty species of Bartonella, and seventeen of these can infect humans[11]. This bacteria has been found to infect the liver, lymph nodes, skin[12], teeth[13], bones, heart, spleen, eyes, kidney, and brain[14]. This infection manipulates the circulatory system to spread through the body.

Bartonella stimulates the production of vascular endothelial growth factor (VEGF) to invade the body

VEGF is produced in the body to stimulate the production of new blood vessels[15]. In one study that looked at two species of Bartonella henselae, genotype I, aka Houston-1, and II, aka Marseille strain, genotype I was more virulent in human cells due to it’s ability to increase VEGF production and it’s receptor VEGFR-2 in human microvascular endothelial cells[16]. As new blood vessels grow due to VEGF production, Bartonella is then able to infect and spread through the endothelial cell lining of these new vessels[17]. Antibiotics are often the first course of treatment.

Antibiotics are highly effective in killing Bartonella in the lab but not as effective in people

In multiple lab studies, Bartonella was successfully eliminated using these antibiotics: amoxycillin and ceftriaxone, aminoglycosides, doxycycline, rifampicin, erythromycin doxycycline, and ciprofloxacin[18]. However, treatment failures and relapses have been reported with rifampin, ciprofloxacin, gentamicin, co-trimoxazole, and azithromycin[19]. One reason for these failures may be due to resistant strains of Bartonella to antibiotics: quinolones[20], rifampin[21], macrolides[22], fluoroquinolones[23], and gentamicin[24]. Another reason for antibiotic treatment failure may be due to this bacterias ability to produce or to hide within a protective slime called a biofilm. In one study, B. quintana was discovered in a exopolysaccharide (EPS)-like matrix, i.e. bioflm, in lice feces[25]. Biofilms are believed to increase drug resistance up to a thousand times[26]. This infection can produce a wide variety of physical and emotional symptoms.

Bartonella can produce many symptoms including anger, rage and obsessive compulsive disorder (OCD) behaviors
A Bartonella infection can produce symptoms of anemia[27], frequent headaches, visual and auditory hallucinations, anxiety, vision loss, paralysis, facial palsy, chronic insomnia, seizures, dizziness, cognitive dysfunction, and memory loss[28]. It has been found to mimic symptoms of multiple sclerosis (MS)[29], stroke[30], vasculitis[31], breast tumors, pancreatic, biliary or pharyngeal cancer[32], and rheumatic disease[33]. One Lyme literate specialist reports anger, rage and obsessive compulsive behavior in her Bartonella patients[34]. Obsessive behavior may be associated with a reaction in a specific area of the brain.

A specific region of the brain called the basal ganglia is associated with obsessive compulsive behavior

Obsessive compulsive behaviors are a signature symptom in children diagnosed with Pediatric Autoimmune Disorders Associated with Strep (PANDAS). In children with PANDAs, an infection by group A beta-hemolytic streptococcus (GABHS), toxins, or inflammation stimulates an autoimmune reaction in the basal ganglia area of the brain[35]. This reaction produces obsessive compulsive disorder (OCD) behaviors[36]. In one study, 19% of Bartonella patients showed lesions on brain MRIs in the cerebral white matter, basal ganglia, thalamus, and gray matter[37]. If Bartonella can produce abnormal MRI lesions in the basal ganglia, then it may be capable of producing OCD behaviors similar to a PANDAS infection.

What else can help you to stop a resistant Bartonella infection that produces angry outbursts, rage, or obsessive compulsive behaviors?

In Chinese medicine, anger, rage, and compulsive behaviors are associated with an imbalance in the liver

In Chinese medicine, when the liver becomes too hot or too dry due to excess toxins, a person may exhibit symptoms of sudden anger or rage[38]. A Chinese medicine diagnosis of liver stagnation, also known as congestion, along with a spleen deficiency is associated with OCD behaviors[39]. Obsessive compulsive behaviors have also been identified in people with toxic parasitic infections called Gu Syndrome in Chinese medicine texts[40]. Some patients with obsessive behaviors report a need to have their environment in a precise order by putting things in a specific place, extreme anxiety over unexpected surprises that disrupt daily rituals, or thoughts like, “Did I lock the door?” that they worry about over and over again. Fortunately, there are four herbs which may help to reduce obsessive behaviors, inhibit VEGF production, and lower rage by cooling and moistening the liver.

Here are four herbs for stopping Bartonella from spreading and causing painful emotions

Limiting VEGF production may help to stop Bartonella from spreading. Harmonizing the liver is a Chinese medicine strategy for lowering rage and obsessive compulsive behaviors. Formulating remedies into microparticles called liposomes increases their penetration into endothelial cells[41] where Bartonella hides out, the liver[42], and the basal ganglia[43] Liposomal remedies have also been effective at reducing the production of VEGF[44] and its receptor VEGFR2[45], which may help to limit the virulence of Bartonella. These herbs have been used for centuries in traditional medicine formulas for treating angry outbursts, rage, and obsessive compulsive disorder (OCD) behavior.

Stopping Bartonella Rage and OCD Herb #1: Angelica sinensis

Angelica sinensis, Chinese name Dang Gui, has antimicrobial, neuro-protective, anticancer, anticoagulant, and liver-protective properties. In Chinese medicine, angelica is used to strengthen and replenish the blood and it’s used to treat anemia, pale complexion, dry hair, dizziness, blurred vision, fatigue and weakness, palpitations and pain[46]. It is a primary ingredient in multiple Chinese herbal formulas for reducing angry outbursts or rage due to a liver imbalance[47] called liver yin deficiency or liver fire blazing.

In a lab study, angelica was effective at reducing VEGF[48]. In another study, angelica was effective at increasing cognitive abilities and brain plasticity of rats when under chronic stress[49]. Angelica also has demonstrated anti-endotoxin properties in multiple animal studies[50]. This herb has demonstrated an inhibitory effect on Salmonella typhi, E. coli, Corynebacterium diptheriae, Vibrio cholerae, alpha-hemolytic streptococcus, and beta-hemolytic streptococcus[51]. Another herb that is often used with angelica is peony.

Stopping Bartonella Rage and OCD Herb #2: White peony root

White peony root, Chinese name Bai Shao, has anti-inflammatory, antibiotic, CNS calming, and digestion healing properties. In Chinese medicine, white peony is used to nourish the blood, treat anemia, regulate menstrual disorders, relieve pain, reduce night sweats, nourish, cool and soften the liver[52]. A compound found in white peony called total glucosides was effective in reducing the abnormal proliferation of VEGF in a rat study[53]. Paeoniflorin, another component of white peony, demonstrated liver protective[54] and anti-endotoxin[55] properties in multiple animal studies. Albiflorin, another compound in white peony, demonstrated similar anti-inflammatory properties compared to paeoniflorin[56].

This herb has shown to have an inhibitory effect against Bacillus dysenteriae, E. Coli, Salmonella typhi, Pseudonomas aeruginosa, Staphyloccus aureus, beta-hemolytic streptococcus, and Diplococcus pneumoniae[57]. Peony is often paired with angelica in herbal formulas for treating liver imbalances, including those that are marked by irritation, rage, and angry outbursts[58]. Bupleurum is another herb used in traditional Chinese medicine for supporting the liver.

Stopping Bartonella Rage and OCD Herb #3: Bupleurum

Bupleurum, Chinese name Chai Hu, has pathogen expelling, anti-malarial, liver harmonizing, and yang lifting properties. In Chinese medicine, bupleurum is used to treat infections with symptoms of fever, chills, fullness in the chest, bitter taste in the mouth, dry throat, poor appetite, nausea, vertigo, and irritability. This herb is often used to treat malaria, emotional distress, eye disorders, breast swelling and pain, irregular menstruation, jaundice, migraines, and prolapsed organs[59]. In Chinese herbal formulas, this herb is used to release anger and frustration that is inexpressible[60].

This herb has an inhibitory effect on B-hemolytic streptococcus, Vibrio cholerae, Mycobacterium tuberculosis, leptospirosis (a spirochete infection), influenza viruses, and hepatitus viruses Buplerum is cautioned in patients with excessive dryness and heat symptoms. There may an increased risk of acute pneumonitis when this herb is used with interferon[61]. Polysaccharides found in this herb have anti-toxin properties[62]. Bupleurum reduced depression in one human study by increasing Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF)[63]. In a rat study, an herbal formula with bupleurum was effective at reducing inflammatory cytokines causing jaundice and liver hepatitis[64]. Bupleurum is a component with angelica and white peony in a famous formula called “Rambling Powder” to treat liver stagnation[65]. Withania somnifera is another herb for calming the emotions.

Stopping Bartonella Rage and OCD Herb #4: Withania somnifera

Withania somnifera, also called ashwagandha, has a very revered place in ayurvedic medicine. It’s properties are tonifying, replenishing, longevity enhancing, adaptogenic, stress reducing, anti-tumor, neuroregenerative, anti-arthritic, aphrodisiac, narcotic, diuretic, anthelmintic, astringent, thermogenic, and stimulant[66].

Withania somnifera has been used to treat the following conditions: arthritis, inflammatory conditions, anxiety, insomnia, respiratory disorders, asthma, and bronchitis. It is also used to treat disorders of the nervous, immune, and the reproductive system. It is especially used to treat nervousness, depression, digestion problems, and low libido[67]. This herb has also been used to treat gastric ulcers, uterine fibroids, dementia, memory problems, Parkinson’s, Huntington’s, Alzheimer’s disease, mitochondrial energy depletion, rheumatoid, and osteoarthritis[68].

In one mouse study, Withania somnifera was effective at inhibiting obsessive compulsive behavior[69]. In a rat study, Withania somnifera demonstrated liver protective and anti-inflammatory effects against gentamicin liver damage[70]. This herb was also effective in multiple studies against Staphylococcus aureus, Methicilin Resistance Staphylococcus aureus (MRSA)[71], Enterococcus spp.[72], Escherichia coli, Salmonella typhi, Citrobacter freundii, Pseudomonas aeruginosa, Klebsiella pneumoniae[73], Aeromonas hydrophila[74], Plasmodium berghei[75], Linoleic and oleic acids from Withania somnifera were effective at inhibiting streptococcus mutans biofilms[76]. Withaferin A and withanone are compounds found in this herb that show inhibitiatory potential against leshmania protozoa[77]. Withaferin A also inhibited the production of H. pylori induced inflammatory compound IL-1beta[78], MMP-9[79] produced by metastatic cancer cells, and VEGF produced by brain cancer cells[80] in lab experiments. Using a combination of these herbs can help to fight the uncomfortable emotions triggered by a Bartonella infection.

These four herbs can help to reduce painful emotions of rage and obsessive compulsive behaviors from a Bartonella infection

People with Lyme disease that have uncontrolled anger, rage and obsessive behaviors may have a stealthy Bartonella infection affecting their liver and nervous system. Similar to canceling a credit card with fraudulent charges, these herbs may help to stop the spread of Bartonella through inhibiting VEGF. By harmonizing and decongesting the liver, these herbs may help to reduce angry outbursts and obsessive compulsive behaviors. Using liposomal anti-Bartonella herbs may be more effective in stopping Bartonella inside the liver, the basal ganglia in the brain, and in endothelial cells. Since some of these herbs have cautions on their use, work with a Lyme literate natural remedy practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday August 1st at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing from Lyme disease and co-infection symptoms.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to stop angry outbursts, rage, or obsessive compulsive behaviors due to a Bartonella infection? Tell us about it.


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[56]Wang, Qiang-Song, Teng Gao, Yuan-Lu Cui, Li-Na Gao, and Heng-Li Jiang. “Comparative Studies of Paeoniflorin and Albiflorin from Paeonia Lactiflora on Anti-Inflammatory Activities.” Pharmaceutical Biology 52, no. 9 (September 2014): 1189–95. doi:10.3109/13880209.2014.880490. http://www.ncbi.nlm.nih.gov/pubmed/24646307

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[62]Wu, Jian, Yun-Yi Zhang, Li Guo, Hong Li, and Dao-Feng Chen. “Bupleurum Polysaccharides Attenuates Lipopolysaccharide-Induced Inflammation via Modulating Toll-like Receptor 4 Signaling.” PloS One 8, no. 10 (2013): e78051. doi:10.1371/journal.pone.0078051. http://www.ncbi.nlm.nih.gov/pubmed/24167596

[63]Wang, Xia, Qing Feng, Yong Xiao, and Ping Li. “Radix Bupleuri Ameliorates Depression by Increasing Nerve Growth Factor and Brain-Derived Neurotrophic Factor.” International Journal of Clinical and Experimental Medicine 8, no. 6 (2015): 9205–17. http://www.ncbi.nlm.nih.gov/pubmed/26309578

[64]Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. http://www.ncbi.nlm.nih.gov/pubmed/22562737

[65]Beau. “Psychospiritual Aspects of Herbal Medicine.” Accessed July 28, 2016. https://www.planetherbs.com/theory/psychospiritual-aspects-of-herbal-medicine.html.

[66]Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. “An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary, and Alternative Medicines 8, no. 5 Suppl (July 3, 2011): 208–13. doi:10.4314/ajtcam.v8i5S.9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/

[67]Beau. “Ashwagandha: Wonder Herb of India.” Accessed July 28, 2016. https://www.planetherbs.com/specific-herbs/ashwagandha-wonder-herb-of-india.html.

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[69]Kaurav, Bhanu P. S., Manish M. Wanjari, Amol Chandekar, Nagendra Singh Chauhan, and Neeraj Upmanyu. “Influence of Withania Somnifera on Obsessive Compulsive Disorder in Mice.” Asian Pacific Journal of Tropical Medicine 5, no. 5 (May 2012): 380–84. doi:10.1016/S1995-7645(12)60063-7. http://www.ncbi.nlm.nih.gov/pubmed/22546655

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[72]Bisht, Punum, and Vinita Rawat. “Antibacterial Activity of Withania Somnifera against Gram-Positive Isolates from Pus Samples.” Ayu 35, no. 3 (September 2014): 330–32. doi:10.4103/0974-8520.153757. http://www.ncbi.nlm.nih.gov/pubmed/25972723

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Jul 8 16

Is Memory Loss Caused by Neurological Lyme Disease or Brain Eating Parasites?

by Greg

wasp_nest

For people with neurological Lyme disease that have dementia, multiple sclerosis, or Alzheimer’s disease
by Greg Lee
.
One afternoon, I heard one of my daughters cry out with a huge scream after a wasp stung her arm. After she was taken care of, I got out my wasp fighting gear: electric bug zapper, thick gloves, hat, and a bottle of hair spray. You may be asking, “Why hair spray?” It sticks like glue to the wasp’s wings so they can’t fly and I don’t like pesticides. Once they hurt my girl, then it got personal and they had to go!

So it was me against over a dozen wasps. After zapping and spraying them into submission, I saw one of the wasps crawl into a slot between two deck boards. And then another wasp followed. I cautiously peered into the slot and saw the nest. I got out the garden hose and sprayed that nest until no wasp remained. Then I quickly pried it out and threw it down the sewer. Once the nest was gone, the rest got the message and didn’t return.

How is being stung by angry wasps defending their nest similar to nematodes that infect the brain?

Just like a wasp nest that swarms you, nematodes can infect and damage the brain
Recent research by Dr. Alan MacDonald has found worms called nematodes in autopsy brain tissue samples from patients with neurological Lyme disease who were also diagnosed with Multiple Sclerosis, dementia, brain tumors, and Alzheimer’s Disease[1]. Lyme disease bacteria were actually detected within some of the nematodes. Similar to how wasps can hide in their nest, Lyme bacteria can hide from antibiotic treatment when they are inside of larger parasitic worms. Unfortunately, nematodes have also been detected in ticks.

In deer ticks and lone star ticks, nematodes have been detected
In multiple tick studies, nematodes have been detected in lone star ticks found in Maryland[2] and Virginia[3], and in deer ticks from Connecticut[4]. Ticks are capable of transmitting nematodes when they feed on a host[5]. Other vectors that can transmit nematodes are mosquitoes and black flies[6]. Once they infect a host, adult nematodes mate and then release thousands of very small larva called “microfilariae” into the blood. Microfilariae circulate throughout the host and can end up in the nervous system[7]. These microfilariae evolve into larvae which can eat through the brain and can cause a wide range of symptoms.

Nematodes produce many symptoms when they infect the brain and spinal fluid
Larval nematodes in the nervous system can damage tissues and produce masses called granulomas. They can also cause fibrosis, blockages in cerebral blood vessels, or inflammation resulting in meningitis, encephalitis or localized inflammation[8], weakness, blurred vision, stomach flu[9], and even death. In a Taiwan study, patients infected with nematodes reported meningitis, brain inflammation, fever, vomiting, headache, and neuropathy. Two patients died from their infection. In some patients, nematodes were recovered from their cerebral-spinal fluid (CSF). Elevated levels of inflammatory markers vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and matrix metalloproteinase 9 (MMP-9) were also detected in patient’s CSF fluid[10]. Research shows that nematodes can also manipulate the immune system response.

Nematodes produce compounds to deflect how the immune system attacks parasites
One research study on a nematode called B. Malayi, identified proteins that it releases to manipulate the immune response in favor of a parasitic infection[11]. Another study on a filarial nematode infection illustrated how these parasites inhibit the inflammatory response by the immune system[12]. In most cases, anti-parasitic medications are used to treat nematode infections in the nervous system.

Anti-parasitic medications help to kill nematode infections in the brain and spinal fluid
Anti-parasitic medications called antihelminthics are used to treat nematodes in the nervous system including: Mebendazole, Pyrantel pamoate, Thiabendazole, Diethylcarbamazine (DEC), Ivermectin[13], Moxidectin[14], and Alinia[15]. Ivermectin and moxidectin are the most widely administrated antihelminthic medications for nematode infections and unfortunately, their widespread and frequent use has led to high level of resistance to these drugs[16]. Ivermectin only kills the microfilariae, not the adult nematode[17]. DEC can worsen onchocercal nematode eye infections. In patients with a nematode infection called loiasis, DEC can cause serious adverse reactions, including encephalopathy and death, depending upon the density of the parasites. DEC is only available in the US from the CDC upon submitting positive lab results[18]. A mechanism within nematodes called a “drug effux pump” is believed to enable these parasites to develop drug resistance[19]. Killing nematodes can lead to significant Herxheimer reactions.

A symbiotic bacteria within nematodes is the source of Herxheimer toxins
Wolbachia is a symbiotic bacteria which enables normal development and fertility of nematodes[20]. Wolbachia belong to the order Rickettsiales and is closely related to Anaplasma, Ehrlichia and Rickettsia[21]. Fortunately, this bacteria does not infect people. When nematodes are killed off by anti-parasitic drugs, Wolbachia cannot survive without their host and are killed, which releases their endotoxins. Wolbachia toxins stimulate the production of pro-inflammatory compounds including tumor necrosis factor alpha (TNF)-alpha, Interleukin-1 (IL-1), and Interleukin-12 (IL-12)[22]. In an animal study, Wolbachia surface protein upregulated (IL)-1beta, IL-6, and tumor necrosis factor[23]. These endotoxins and inflammatory compounds can produce painful symptoms associated with a Herxheimer reaction. A combination of anti-parasitic and antibiotic medications is more effective at reducing adult and microfilariae forms of nematodes.

A combination of medications which kill both the adult and microfilariae forms is more effective
Recent drug strategies combine Ivermectin for microfilariae and doxycycline to kill Wolbachia which eventually kills the adult nematodes in the nervous system. This combination drug treatment is recommended for six weeks[24]. Another animal study combined DEC with liposomal doxycycline and liposomal rifampin resulting in significant increase in microfilariae die off and a marginal increase in the die off of adult nematodes[25]. Other studies demonstrate the inhibitory effect of anti-Rickettsia antibiotics like tetracycline, rifampin, and azithromyacin on adult nematodes[26].

What else can help people to expel brain-eating nematodes from their central nervous system who have persistent neurological Lyme disease, multiple sclerosis, dementia, brain tumors, or Alzheimer’s disease?

Here are four strategies for expelling brain-eating nematodes from the central nervous system
A combination of remedies for attacking both the adult and microfilariae forms is the most effective at reducing the overall numbers of parasites. Formulating remedies into microparticles called liposomes enhances the efficacy of anti-parasitic herbs and essential oils for killing the different life stages of nematodes[27] and possibly their symbiotic bacteria.

Clearing Brain-Eating Nematodes Strategy #1: Essential Oils
Essential oils have been found to inhibit different species of nematodes.

Thyme essential oil was effective at inhibiting Meloydogine javanica[28] and larvae from the Anisakis nematode[29]. Thyme essential oil was also effective against gram negative bacteria: Pseudomonas aeruginosa[30], Salmonella spp.[31], and E. Coli[32]. Thyme combined with oregano oil reduced mRNA levels of pro-inflammatory cytokines IL-1beta, IL-6, GM-CSF, and TNFalpha[33].

Palmarosa essential oil was effective against Caenorhabditis elegans[34] and Haemonchus contortus[35] in separate studies. This oil was also effective at inhibiting E. Coli[36] and Aspergillus fumigatus[37]. Palmarosa oil also reduced pro-inflammatory compounds TNF-α, IL-1β, and IL-8[38] and increased anti-inflammatory IL-10 in lab studies[39].

Clove bud essential oil was highly effective at reducing[40] Meloidogyne incognita egg hatch 50% and killing second stage juveniles (J2) as much as 100% in a lab study[41]. Eugenol, the primary compound in clove bud oil, in one rat study reduced expression of VEGF, MMP-2, and MMP-9[42], which are elevated in nematode infections. Processing these oils into a liposomal micronized form increases their penetration into the nervous system[43]. Adding nanoparticles of silver to liposomal oils may further enhance their anti-microbial properties.

Clearing Brain-Eating Nematodes Strategy #2: Nanoparticle Silver
In multiple lab studies, nanoparticles of silver were effective at reducing motility and killing microfilariae of Brugia malayi[44], demonstrated antifilarial activity against microfilaria of S. Cervi[45], disrupted metabolism of Caenorhabditis elegans[46], and killed most of Meloidogyne incognita[47]. Encapsulating nanoparticles of silver along with essential oils into a liposomal remedy may increase their anti-parasitic and anti-symbiotic bacterial properties. When nanoparticle silver is combined with tea tree essential oil into a liposome, their antimicrobial efficiency is enhanced against Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans[48]. Silver nanoparticles may reduce inflammation from nematodes by inhibiting IL-1beta and VEGF induced permeability as reported in a pig study[49] and reducing MMP-2 and MMP-9 in another rat study[50]. Herbs have also been effective for treating nematode infections for thousands of years.

Clearing Brain-Eating Nematodes Strategy #3: Herbs
In addition to essential oils and silver, herbs have been used for centuries for fighting nematode infections.

Andrographis, Chinese name Chuan Xin Lian, has been effective at inhibiting Haemonchus contortus[51], microfilaricidal activity against Dirofilaria immitis filarids[52], antifilarial activity against adult worms of subperiodic Brugia malayi[53], killing in vitro the microfilaria of Dipetalonema reconditum in dogs[54], and anthelmintic activity against Ascaris lumbricoides[55]. This herb is also used in Chinese medicine against leptospirosis, another spirochete infection[56]. Andrographis was also effective at reducing inflammatory compounds IL-1α, IL-1β, and IL-6 in a lab study[57]. A compound in Andrographis called andrographolide inhibits expression of inflammatory compounds MMP-2, IL-1beta[58] and VEGF[59] in lab studies.

Ajowan, ajwain, or Trachyspermum ammi has been effective against multiple species of nematodes in multiple studies. Methanolic extract of fruits of Trachyspermum ammi were effective against adult bovine filarial Setaria digitata worms and demonstrated macrofilaricidal activity and female worm sterility in vivo against B. Malayi[60].

Lantana camara is an ornamental shrub which is very hardy and is used medicinally through much of the world. This herb contains triterpenoids pomolic acid, lantanolic acid, lantoic acid, camarin, lantacin, camarinin, and ursolic acid which exhibited 100% mortality in 24 – 48 hours against the nematode Meloidogyne incognita[61]. In other studies, a lantana extract killed adult Brugia malayi nematodes and sterilized many of the surviving female worms, and demonstrated strong microfilaricidal and sterilization efficacy with mild macrofilaricidal action against Acanthocheilonema viteae[62]. Not only herbs, but also tiny electrical frequencies can help to stop nematodes that have infected the brain and spinal fluid.

Clearing Brain-Eating Nematodes Strategy #4: Frequency Specific Microcurrent
Frequency Specific Microcurrent uses millionth of an amp electrical currents to reduce parasitic and bacterial infections, toxins and inflammation[63]. Frequencies for inhibiting parasitic worms, symbiotic bacteria, neutralizing toxins and inflammation, reducing tumors, and promoting healing are paired with frequencies to target infected areas of the nervous system: the brain, forebrain, meninges, basal ganglia, spinal cord, spinal fluid, cranial nerves, and eyes[64]. These paired frequencies have also been helpful in reducing symptoms in patients diagnosed with multiple sclerosis, autism, brain inflammation, mold toxicity, and neurological Lyme disease. These four strategies may help people with neurological Lyme to stop an underlying parasitic nematode brain infection.

A combination of anti-parasitic remedies and treatments can help to overcome a chronic neurological Lyme and nematode infection
People diagnosed with multiple sclerosis, Alzheimer’s disease, dementia, or brain tumors may have hidden parasitic nematodes along with Lyme disease in their nervous system. Just like finding and eliminating the wasp nest, expelling parasitic nematodes that harbor Lyme bacteria may help to improve neurological symptoms and memory recall. Using liposomal anti-parasitic and anti-symbiotic bacteria remedies and treatments may be effective in eliminating larger parasites and the Lyme bacteria they contain.

Anti-toxin treatments and remedies may also help with reducing inflammatory compounds which may lower toxic Herxheimer pain and discomfort. Making these remedies into micronized liposomes enhances their delivery into the nervous system and may increase their anti-nematode effectiveness. Since some of these treatments and remedies require specialized training, work with a Lyme literate natural remedy practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday July 11th at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing from Lyme disease and co-infection symptoms.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to overcome memory problems caused by brain-eating parasites or a Lyme disease infection? Tell us about it.


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[37] Khan, Mohd Sajjad Ahmad, and Iqbal Ahmad. “In Vitro Antifungal, Anti-Elastase and Anti-Keratinase Activity of Essential Oils of Cinnamomum-, Syzygium- and Cymbopogon-Species against Aspergillus Fumigatus and Trichophyton Rubrum.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 19, no. 1 (December 15, 2011): 48–55. doi:10.1016/j.phymed.2011.07.005. http://www.ncbi.nlm.nih.gov/pubmed/21893402
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[40] Meyer, Susan LF, Dilip K Lakshman, Inga A Zasada, Bryan T Vinyard, and David J Chitwood. “Dose–response Effects of Clove Oil fromSyzygium Aromaticum on the Root-Knot nematodeMeloidogyne Incognita.” Pest Management Science 64, no. 3 (March 2008): 223–29. doi:10.1002/ps.1502. https://www.researchgate.net/publication/5768878_Dose-response_effects_of_clove_oil_from_Syzygium_aromaticum_on_the_root-knot_nematode_Meloidogyne_incognita
[41] Meyer, Susan LF, Dilip K Lakshman, Inga A Zasada, Bryan T Vinyard, and David J Chitwood. “Dose–response Effects of Clove Oil from Syzygium Aromaticum on the Root-Knot Nematode Meloidogyne Incognita.” Pest Management Science 64, no. 3 (March 2008): 223–29. doi:10.1002/ps.1502. http://www.ncbi.nlm.nih.gov/pubmed/18080287
[42] Manikandan, Palrasu, Ramalingam Senthil Murugan, Ramamurthi Vidya Priyadarsini, Govindarajah Vinothini, and Siddavaram Nagini. “Eugenol Induces Apoptosis and Inhibits Invasion and Angiogenesis in a Rat Model of Gastric Carcinogenesis Induced by MNNG.” Life Sciences 86, no. 25–26 (June 19, 2010): 936–41. doi:10.1016/j.lfs.2010.04.010. http://www.ncbi.nlm.nih.gov/pubmed/20434464
[43] Shibata, S., A. Ochi, and K. Mori. “Liposomes as Carriers of Cisplatin into the Central Nervous System–Experiments with 9L Gliomas in Rats.” Neurologia Medico-Chirurgica 30, no. 4 (April 1990): 242–45. http://www.ncbi.nlm.nih.gov/pubmed/1696693
[44] Singh, Sunil K., Kalyan Goswami, Richa D. Sharma, Maryada V. R. Reddy, and Debabrata Dash. “Novel Microfilaricidal Activity of Nanosilver.” International Journal of Nanomedicine 7 (2012): 1023–30. doi:10.2147/IJN.S28758. http://www.ncbi.nlm.nih.gov/pubmed/22393295
[45] Saini, Prasanta, Swadhin Kr Saha, Priya Roy, Pranesh Chowdhury, and Santi P. Sinha Babu. “Evidence of Reactive Oxygen Species (ROS) Mediated Apoptosis in Setaria Cervi Induced by Green Silver Nanoparticles from Acacia Auriculiformis at a Very Low Dose.” Experimental Parasitology 160 (January 2016): 39–48. doi:10.1016/j.exppara.2015.11.004. http://www.ncbi.nlm.nih.gov/pubmed/26627139
[46] Starnes, Daniel L., Stuart S. Lichtenberg, Jason M. Unrine, Catherine P. Starnes, Emily K. Oostveen, Gregory V. Lowry, Paul M. Bertsch, and Olga V. Tsyusko. “Distinct Transcriptomic Responses of Caenorhabditis Elegans to Pristine and Sulfidized Silver Nanoparticles.” Environmental Pollution (Barking, Essex: 1987) 213 (June 2016): 314–21. doi:10.1016/j.envpol.2016.01.020. http://www.ncbi.nlm.nih.gov/pubmed/26925754
[47] Cromwell, W. A., Joopil Yang, J. L. Starr, and Young-Ki Jo. “Nematicidal Effects of Silver Nanoparticles on Root-Knot Nematode in Bermudagrass.” Journal of Nematology 46, no. 3 (September 2014): 261–66. http://www.ncbi.nlm.nih.gov/pubmed/25275999
[48] Low, W. L., C. Martin, D. J. Hill, and M. A. Kenward. “Antimicrobial Efficacy of Liposome-Encapsulated Silver Ions and Tea Tree Oil against Pseudomonas Aeruginosa, Staphylococcus Aureus and Candida Albicans.” Letters in Applied Microbiology 57, no. 1 (July 2013): 33–39. doi:10.1111/lam.12082. http://www.ncbi.nlm.nih.gov/pubmed/23581401
[49] Sheikpranbabu, Sardarpasha, Kalimuthu Kalishwaralal, Deepak Venkataraman, Soo Hyun Eom, Jongsun Park, and Sangiliyandi Gurunathan. “Silver Nanoparticles Inhibit VEGF-and IL-1β-Induced Vascular Permeability via Src Dependent Pathway in Porcine Retinal Endothelial Cells.” Journal of Nanobiotechnology 7 (2009): 8. doi:10.1186/1477-3155-7-8. https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-7-8
[50] Liu, Binbin. “In Vitro Cytotoxicity of Silver Nanoparticles in Primary Rat Hepatic Stellate Cells.” Molecular Medicine Reports, September 13, 2013. doi:10.3892/mmr.2013.1683. https://www.spandidos-publications.com/mmr/8/5/1365
[51] Kamaraj, Chinnaperumal, Abdul Abdul Rahuman, Gandhi Elango, Asokan Bagavan, and Abdul Abduz Zahir. “Anthelmintic Activity of Botanical Extracts against Sheep Gastrointestinal Nematodes, Haemonchus Contortus.” Parasitology Research 109, no. 1 (July 2011): 37–45. doi:10.1007/s00436-010-2218-y. http://www.ncbi.nlm.nih.gov/pubmed/21161270
[52] Merawin, L. T., A. K. Arifah, R. A. Sani, M. N. Somchit, A. Zuraini, S. Ganabadi, and Z. A. Zakaria. “Screening of Microfilaricidal Effects of Plant Extracts against Dirofilaria Immitis.” Research in Veterinary Science 88, no. 1 (February 2010): 142–47. doi:10.1016/j.rvsc.2009.05.017. http://www.ncbi.nlm.nih.gov/pubmed/19500810
[53] Zaridah, M. Z., S. Z. Idid, A. W. Omar, and S. Khozirah. “In Vitro Antifilarial Effects of Three Plant Species against Adult Worms of Subperiodic Brugia Malayi.” Journal of Ethnopharmacology 78, no. 1 (November 2001): 79–84. http://www.ncbi.nlm.nih.gov/pubmed/11585692
[54] Dutta, A., and N. C. Sukul. “Filaricidal Properties of a Wild Herb, Andrographis Paniculata.” Journal of Helminthology 56, no. 2 (June 1982): 81–84. http://www.ncbi.nlm.nih.gov/pubmed/7201486
[55] Raj, R. K. “Screening of Indigenous Plants for Anthelmintic Action against Human Ascaris Lumbricoides: Part–II.” Indian Journal of Physiology and Pharmacology 19, no. 1 (March 1975): UNKNOWN. http://www.ncbi.nlm.nih.gov/pubmed/1158424
[56] “Lyme Disease: Treatment with Chinese Herbs.” Accessed June 23, 2016. http://www.itmonline.org/arts/lyme.htm.
[57] Salim, Emil, Endang Kumolosasi, and Ibrahim Jantan. “Inhibitory Effect of Selected Medicinal Plants on the Release of pro-Inflammatory Cytokines in Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells.” Journal of Natural Medicines 68, no. 3 (July 2014): 647–53. doi:10.1007/s11418-014-0841-0. http://www.ncbi.nlm.nih.gov/pubmed/24799081
[58] Tangyuenyong, Siriwan, Nawarat Viriyakhasem, Siriporn Peansukmanee, Prachya Kongtawelert, Siriwan Ongchai, Siriwan Tangyuenyong, Nawarat Viriyakhasem, Siriporn Peansukmanee, Prachya Kongtawelert, and Siriwan Ongchai. “Andrographolide Exerts Chondroprotective Activity in Equine Cartilage Explant and Suppresses Interleukin-1β-Induced MMP-2 Expression in Equine Chondrocyte Culture, Andrographolide Exerts Chondroprotective Activity in Equine Cartilage Explant and Suppresses Interleukin-1β-Induced MMP-2 Expression in Equine Chondrocyte Culture.” International Scholarly Research Notices, International Scholarly Research Notices 2014, 2014 (October 30, 2014): e464136. doi:10.1155/2014/464136, 10.1155/2014/464136. http://www.hindawi.com/journals/isrn/2014/464136/
[59] Zhao, Feng, En-Qi He, Lu Wang, and Ke Liu. “Anti-Tumor Activities of Andrographolide, a Diterpene from Andrographis Paniculata, by Inducing Apoptosis and Inhibiting VEGF Level.” Journal of Asian Natural Products Research 10, no. 5–6 (June 2008): 467–73. doi:10.1080/10286020801948334. http://www.ncbi.nlm.nih.gov/pubmed/18464090
[60] Mathew, Nisha, Shailja Misra-Bhattacharya, Vanamail Perumal, and Kalyanasundaram Muthuswamy. “Antifilarial Lead Molecules Isolated from Trachyspermum Ammi.” Molecules (Basel, Switzerland) 13, no. 9 (2008): 2156–68. http://www.ncbi.nlm.nih.gov/pubmed/18830147
[61] Begum, Sabira, Syeda Qamar Zehra, Bina Shaheen Siddiqui, Shahina Fayyaz, and Musarrat Ramzan. “Pentacyclic Triterpenoids from the Aerial Parts of Lantana Camara and Their Nematicidal Activity.” Chemistry & Biodiversity 5, no. 9 (September 2008): 1856–66. doi:10.1002/cbdv.200890173. http://www.ncbi.nlm.nih.gov/pubmed/18816515
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May 31 16

How These Five Remedies Stop Persistent Gut Problems Caused by Listeria in People with Lyme Disease

by Greg

hitchhiker_seeds

For people with Lyme disease that have recurring digestion problems, leaky gut, or small intestine bacterial overgrowth (SIBO)
by Greg Lee

I used to play football and baseball with other neighborhood boys at Mr. Johnson’s field. Occasionally we’d have to go looking for one of our balls at the far end of the field which had tall grass and weeds. Sometimes I’d come out with “hitchhiker” weed seeds clinging to my clothes.

How are hitchhiker seeds similar to people with Lyme disease that have chronic digestion problems?

Just like seeds that sneak on to your clothes, Listeria can be a dangerous pathogen which sneaks into the intestines
In several different recalls of food products, Listeria monocytogenes was cited as a contaminant in multiple food processing plants which produce frozen food, fruit, ice cream, cheese, and sunflower seeds. In another incidence, Listeria was found in whole cantaloupes that ended up sickening 147 people and resulted in 43 fatalities[1]. According to one CDC report, Listeria can be fatal in 21% of cases[2] even despite early antibiotic treatment[3]. Fatality may be as high as 40-60% in patients with a central nervous system infection and concurrent debilitating disease[4]. People over 65, pregnant women and especially their unborn children, and immune compromised patients like people with chronic Lyme or co-infections are at greater risk. Fortunately, the risk of getting a Listeria infection is low, about 2-3 people per million in the US. However, the risk is greater in immune compromised people, even at low doses of Listeria contamination on food[5]. This infection usually starts with symptoms in the digestion system.

Listeria often presents with bloating, nausea, and diarrhea
This infection can produce symptoms of fever and muscle aches, sometimes preceded by diarrhea or other gastrointestinal symptoms. In 55-70% of cases, Listeria can affect the central nervous system (CNS)[6].  When Listeria spreads beyond the digestion tract, it can produce symptoms of headache, stiff neck, confusion, loss of balance, convulsions, meningitis, septicemia, and death[7]. Some immune compromised patients may not have any symptoms. Listeria employs multiple methods to spread through unsuspecting people.

Listeria uses multiple methods to help it to spread through the body
The first line of defense against food borne Listeria are the endothelial cells which line the intestines. Listeria employs multiple strategies to invade several different types of cells and spread through the body: intestinal epithelial cells, hepatocytes, placental cytotrophoblasts, endothelial cells, macrophages and other immune cells[8]. In one lab study, listeriolysin O (LLO) is a toxin produced by Listeria which enables it to move freely inside of and to propagate between endothelial cells[9]. This toxin also disables “T” cells which enable this bacteria to evade the immune system and survive longer[10]. Listeria has also developed drug resistance to multiple antibiotics.

Listeria can persist due to drug resistance to many antibiotics
Unfortunately, mutant strains of Listeria have developed resistance to several antibiotics including: ampicillin, cephalothin, penicillin, meticillin, oxacillin[11],  tetracycline, streptomycin, cefotaxime, and gentamicin[12]. Listeria uses a mechanism called an effux pump to sample drug molecules to develop drug-resistance[13]. This bacteria can also produce biofilms under which many species of pathogens may live, which suggests that Listeria is likely capable of long-term infection in the gut[14]. In one study on sanitizers, Listeria under a biofilm demonstrated increased resistance of 1000 times[15]. In another lab study, Listeria has also been shown to be capable of receiving drug resistant genes from other bacteria that contaminate food[16]. Unfortunately, some Lyme disease patients with chronic digestion problems have tested positive for resonant frequencies for Listeria in their intestines.

What else can help people with Lyme disease to fight a drug-resistant, biofilm forming, intracellular Listeria gut and central nervous system infection?

Here are five strategies for stopping Listeria infections in the gut and the central nervous system
Here are four strategies for helping to stop Listeria from spreading. Making remedies into a small particle size can increase their anti-Listeria properties. When anti-Listeria medicines were processed into small particles and wrapped with a lipid or a fat outer layer called a liposome, they had a 90-fold greater effect at killing the intracellular infection in mice[17]. Liposomal remedies have been shown to be more effective at penetrating and delivering remedies into Listeria infected cells than their non-liposomal equivalents[18]. In other studies, herbs, specific frequencies of light, and dietary changes inhibited Listeria.

Listeria Stopping Strategy #1: Essential Oils
In one lab study, five plant essential oils: bay, clove, cinnamon, nutmeg and thyme significantly reduced the toxin listeriolysin O[19], which can help to prevent Listeria monocytogenes from spreading through the body. In another lab study, nanoemulsions of anise oil were more effective at inhibiting Listeria than anise essential oil[20]. Other lab studies indicated the effectiveness of oregano[21], lemongrass[22], spearmint[23], clove[24], myrtle[25], ajowan[26], orange[27], peppermint[28], geranium[29], artemisia annua[30], cinnamon Chinese cassia, red thyme[31], lemon and cinnamon[32] essential oils against Listeria monocytogenes. In lab experiments, thyme and oregano[33] essential oils were also effective at eliminating the biofilm forms of Listeria. Encapsulation the oils in liposomes, increases their effectiveness at targeting intracellular L. monocytogenes in endothelial cells[34] and the central nervous system[35]. Not only oils can help with stopping Listeria, so can specific wavelengths of light.

Listeria Stopping Strategy #2: Light Therapy
Light Emitting Diode (LED) frequencies of 405 nm[36] and 461 nm[37] inactivated L. monocytogenes in multiple lab experiments. Applying these wavelengths to the skin may help with stopping a cutaneous Listeria[38] infection. In studies on the penetration depth of laser wavelengths of 405 nm, this frequency was able to penetrate to a depth of 0.08 mm with 55% transmission into fair colored skin, and 2.5% in darker skin[39]. In addition to light, herbs can also help with stopping Listeria.

Listeria Stopping Strategy #3: Herbs
In addition to essential oils and light frequencies, these herb extracts have anti-Listeria properties in one study: rosemary, Echinacea angustifolia, thyme, tea tree, and peppermint[40]. In other studies, green tea was effective at inhibiting Listeria in food[41]. A green tea compound called epigallocatechin gallate (ECGC) was also effective at inhibiting the intracellular growth of L. Monocytogenes in a macrophage study[42]. Processing these herbs into small particle liposomes enhances their ability to penetrate and stop intracellular Listeria[43] and potentially disrupt it’s biofilms[44]. Not only herbs, but also tiny electrical frequencies can help to stop a Listeria infection.

Listeria Stopping Strategy #4: Frequency Specific Microcurrent
Frequency Specific Microcurrent uses millionth of an amp electrical currents to reduce bacterial infections, toxins and inflammation[45]. Frequencies for reducing pathogens, neutralizing toxins and inflammation, and promoting healing are combined with frequencies to target Listeria hiding inside blood cells[46], and organs like the intestines[47], liver, spleen[48], and the central nervous system[49]. These paired frequencies have been helpful in reducing symptoms in patients with meningitis, headaches, and confusion. In addition to microcurrent, dietary changes can also help to fight Listeria.

Listeria Stopping Strategy #5: Dietary Changes
In multiple studies, these foods and supplements inhibited the growth of Listeria: virgin olive oil[50], zinc and isomeric vitamin A[51], feijoa fruit extract from New Zealand[52], Lactobacilus[53] and Bifidobacterium[54] probiotics. Eliminating alcohol intake may also help with boosting the strength of your innate immunity against Listeria[55]. Multiple strategies can help people with Lyme to stop a persistent Listeria gut or brain infection.

A combination of anti-Listeria strategies can help to resolve a chronic gastrointestinal problems or infections in people with Lyme disease
Similar to taking the hitchhiking seeds off your clothes, anti-Listeria remedies and treatments may help to resolve chronic digestion problem, gut infections and meningitis. Processing these oils and herbs into a small particle liposome can enhance their antimicrobial, antibiofilm properties, and ability to penetrate inside cells and into the central nervous system. Some patients will also take these oils or herb extracts in an enema to increase their delivery into the intestines. Since some of these oils and herbs have cautions on their use, work with a Lyme literate natural remedy practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday June 6th at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing from Lyme disease and co-infection symptoms.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to overcome chronic gut problems caused by a toxic Listeria infection? Tell us about it.



[1] “Multistate Outbreak of Listeriosis Linked to Whole Cantaloupes from Jensen Farms, Colorado | Listeria | CDC.” Accessed May 21, 2016. http://www.cdc.gov/listeria/outbreaks/cantaloupes-jensen-farms/index.html.

[2] “Vital Signs: Listeria Illnesses, Deaths, and Outbreaks — United States, 2009–2011.” Accessed May 21, 2016. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6222a4.htm.

[3] Vázquez-Boland, José A., Michael Kuhn, Patrick Berche, Trinad Chakraborty, Gustavo Domínguez-Bernal, Werner Goebel, Bruno González-Zorn, Jürgen Wehland, and Jürgen Kreft. “Listeria Pathogenesis and Molecular Virulence Determinants.” Clinical Microbiology Reviews 14, no. 3 (July 2001): 584–640. doi:10.1128/CMR.14.3.584-640.2001. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88991/#B422

[4] Vázquez-Boland, et al. “Listeria Pathogenesis and Molecular Virulence Determinants.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88991/#

[5] Vázquez-Boland, et al. “Listeria Pathogenesis and Molecular Virulence Determinants.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88991/#

[6] Vázquez-Boland, et al. “Listeria Pathogenesis and Molecular Virulence Determinants.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88991/#

[7] “Definition & Symptoms | Listeria | CDC.” Accessed May 21, 2016. http://www.cdc.gov/listeria/definition.html.

[8] Vázquez-Boland, José A., Michael Kuhn, Patrick Berche, Trinad Chakraborty, Gustavo Domínguez-Bernal, Werner Goebel, Bruno González-Zorn, Jürgen Wehland, and Jürgen Kreft. “Listeria Pathogenesis and Molecular Virulence Determinants.” Clinical Microbiology Reviews 14, no. 3 (July 2001): 584–640. doi:10.1128/CMR.14.3.584-640.2001. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88991/

[9] Rengarajan, Michelle, Arnold Hayer, and Julie A. Theriot. “Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria Monocytogenes.” PLoS Pathogens 12, no. 5 (May 6, 2016). doi:10.1371/journal.ppat.1005603. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859537/

[10] Yamamoto, K., I. Kawamura, T. Tominaga, T. Nomura, C. Kohda, J. Ito, and M. Mitsuyama. “Listeriolysin O, a Cytolysin Derived from Listeria Monocytogenes, Inhibits Generation of Ovalbumin-Specific Th2 Immune Response by Skewing Maturation of Antigen-Specific T Cells into Th1 Cells.” Clinical and Experimental Immunology 142, no. 2 (November 2005): 268–74. doi:10.1111/j.1365-2249.2005.02922.x.

[11] Aras, Zeki, and Mustafa Ardıç. “Occurrence and Antibiotic Susceptibility of Listeria Species in Turkey Meats.” Korean Journal for Food Science of Animal Resources 35, no. 5 (2015): 669–73. doi:10.5851/kosfa.2015.35.5.669. http://www.ncbi.nlm.nih.gov/pubmed/26761896

[12] Li, Lili, Rikke Heidemann Olsen, Lei Ye, Wenyan Wang, Lei Shi, He Yan, and Hecheng Meng. “Characterization of Antimicrobial Resistance of Listeria Monocytogenes Strains Isolated from a Pork Processing Plant and Its Respective Meat Markets in Southern China.” Foodborne Pathogens and Disease 13, no. 5 (May 2016): 262–68. doi:10.1089/fpd.2015.2087. http://www.ncbi.nlm.nih.gov/pubmed/27058266

[13] Soto, Sara M. “Role of Efflux Pumps in the Antibiotic Resistance of Bacteria Embedded in a Biofilm.” Virulence 4, no. 3 (April 1, 2013): 223–29. doi:10.4161/viru.23724. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711980/

[14] Giaouris, Efstathios, Even Heir, Mickaël Desvaux, Michel Hébraud, Trond Møretrø, Solveig Langsrud, Agapi Doulgeraki, et al. “Intra- and Inter-Species Interactions within Biofilms of Important Foodborne Bacterial Pathogens.” Frontiers in Microbiology 6 (August 20, 2015). doi:10.3389/fmicb.2015.00841. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542319/

[15] Romanova, Nadya A., Purushottam V. Gawande, Lubov Y. Brovko, and Mansel W. Griffiths. “Rapid Methods to Assess Sanitizing Efficacy of Benzalkonium Chloride to Listeria Monocytogenes Biofilms.” Journal of Microbiological Methods 71, no. 3 (December 2007): 231–37. doi:10.1016/j.mimet.2007.09.002. http://www.ncbi.nlm.nih.gov/pubmed/17928079

[16] Jahan, M., and R. A. Holley. “Transfer of Antibiotic Resistance from Enterococcus Faecium of Fermented Meat Origin to Listeria Monocytogenes and Listeria Innocua.” Letters in Applied Microbiology 62, no. 4 (April 2016): 304–10. doi:10.1111/lam.12553. http://www.ncbi.nlm.nih.gov/pubmed/26854329

[17] Bakker-Woudenberg, I. A., A. F. Lokerse, J. C. Vink-van den Berg, and F. H. Roerdink. “Liposome-Encapsulated Ampicillin against Listeria Monocytogenes in Vivo and in Vitro.” Infection 16 Suppl 2 (1988): S165–70. http://www.ncbi.nlm.nih.gov/pubmed/3138190

[18] Ito, M., E. Ishida, F. Tanabe, N. Mori, and S. Shigeta. “Inhibitory Effect of Liposome-Encapsulated Penicillin G on Growth of Listeria Monocytogenes in Mouse Macrophages.” The Tohoku Journal of Experimental Medicine 150, no. 3 (November 1986): 281–86. http://www.ncbi.nlm.nih.gov/pubmed/3103258

[19] Smith-Palmer, A., J. Stewartt, and L. Fyfe. “Inhibition of Listeriolysin O and Phosphatidylcholine-Specific Production in Listeria Monocytogenes by Subinhibitory Concentrations of Plant Essential Oils.” Journal of Medical Microbiology 51, no. 7 (July 2002): 567–74. doi:10.1099/0022-1317-51-7-567. http://www.ncbi.nlm.nih.gov/pubmed/12132773

[20] Topuz, Osman Kadir, Emin Burçin Özvural, Qin Zhao, Qingrong Huang, Michael Chikindas, and Muharrem Gölükçü. “Physical and Antimicrobial Properties of Anise Oil Loaded Nanoemulsions on the Survival of Foodborne Pathogens.” Food Chemistry 203 (July 15, 2016): 117–23. doi:10.1016/j.foodchem.2016.02.051. http://www.ncbi.nlm.nih.gov/pubmed/26948596

[21] de Souza, Geany Targino, Rayssa Julliane de Carvalho, Jossana Pereira de Sousa, Josean Fechine Tavares, Donald Schaffner, Evandro Leite de Souza, and Marciane Magnani. “Effects of the Essential Oil from Origanum Vulgare L. on Survival of Pathogenic Bacteria and Starter Lactic Acid Bacteria in Semihard Cheese Broth and Slurry.” Journal of Food Protection 79, no. 2 (February 2016): 246–52. doi:10.4315/0362-028X.JFP-15-172. http://www.ncbi.nlm.nih.gov/pubmed/26818985

[22] Leite, Caroline Junqueira Barcellos, Jossana Pereira de Sousa, José Alberto da Costa Medeiros, Maria Lúcia da Conceição, Vivyanne Dos Santos Falcão-Silva, and Evandro Leite de Souza. “Inactivation of Escherichia Coli, Listeria Monocytogenes, and Salmonella Enteritidis by Cymbopogon Citratus D.C. Stapf. Essential Oil in Pineapple Juice.” Journal of Food Protection 79, no. 2 (February 2016): 213–19. doi:10.4315/0362-028X.JFP-15-245. http://www.ncbi.nlm.nih.gov/pubmed/26818981

[23] Shahbazi, Yasser. “Chemical Composition and In Vitro Antibacterial Activity of Mentha Spicata Essential Oil against Common Food-Borne Pathogenic Bacteria.” Journal of Pathogens 2015 (2015): 916305. doi:10.1155/2015/916305. http://www.ncbi.nlm.nih.gov/pubmed/26351584

[24] Mith, Hasika, Rémi Duré, Véronique Delcenserie, Abdesselam Zhiri, Georges Daube, and Antoine Clinquart. “Antimicrobial Activities of Commercial Essential Oils and Their Components against Food-Borne Pathogens and Food Spoilage Bacteria.” Food Science & Nutrition 2, no. 4 (July 2014): 403–16. doi:10.1002/fsn3.116. http://www.ncbi.nlm.nih.gov/pubmed/25473498

[25] Ben Hsouna, Anis, Naceur Hamdi, Ramzi Miladi, and Slim Abdelkafi. “Myrtus Communis Essential Oil: Chemical Composition and Antimicrobial Activities against Food Spoilage Pathogens.” Chemistry & Biodiversity 11, no. 4 (April 2014): 571–80. doi:10.1002/cbdv.201300153. http://www.ncbi.nlm.nih.gov/pubmed/24706627

[26] Rabiey, Soghra, Hedayat Hosseini, and Masoud Rezaei. “Use Carum Copticum Essential Oil for Controlling the Listeria Monocytogenes Growth in Fish Model System.” Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology] 45, no. 1 (2014): 89–96. http://www.ncbi.nlm.nih.gov/pubmed/24948918

[27] Irkin, Reyhan, and Mihriban Korukluoglu. “Growth Inhibition of Pathogenic Bacteria and Some Yeasts by Selected Essential Oils and Survival of L. Monocytogenes and C. Albicans in Apple-Carrot Juice.” Foodborne Pathogens and Disease 6, no. 3 (April 2009): 387–94. doi:10.1089/fpd.2008.0195. http://www.ncbi.nlm.nih.gov/pubmed/19278342

[28] Liang, Rong, Shiqi Xu, Charles F. Shoemaker, Yue Li, Fang Zhong, and Qingrong Huang. “Physical and Antimicrobial Properties of Peppermint Oil Nanoemulsions.” Journal of Agricultural and Food Chemistry 60, no. 30 (August 1, 2012): 7548–55. doi:10.1021/jf301129k. http://www.ncbi.nlm.nih.gov/pubmed/22746096

[29] Ghannadi, A., Mr Bagherinejad, D. Abedi, M. Jalali, B. Absalan, and N. Sadeghi. “Antibacterial Activity and Composition of Essential Oils from Pelargonium Graveolens L’Her and Vitex Agnus-Castus L.” Iranian Journal of Microbiology 4, no. 4 (December 2012): 171–76. http://www.ncbi.nlm.nih.gov/pubmed/23205247

[30] Bilia, Anna Rita, Francesca Santomauro, Cristiana Sacco, Maria Camilla Bergonzi, and Rosa Donato. “Essential Oil of Artemisia Annua L.: An Extraordinary Component with Numerous Antimicrobial Properties.” Evidence-Based Complementary and Alternative Medicine: eCAM 2014 (2014): 159819. doi:10.1155/2014/159819. http://www.ncbi.nlm.nih.gov/pubmed/24799936

[31] Dussault, Dominic, Khanh Dang Vu, and Monique Lacroix. “In Vitro Evaluation of Antimicrobial Activities of Various Commercial Essential Oils, Oleoresin and Pure Compounds against Food Pathogens and Application in Ham.” Meat Science 96, no. 1 (January 2014): 514–20. doi:10.1016/j.meatsci.2013.08.015. http://www.ncbi.nlm.nih.gov/pubmed/24012976

[32] Özcan, Gülçin, and Nükhet Nilüfer Demirel Zorba. “Combined Effect of Ultrasound and Essential Oils to Reduce Listeria Monocytogenes on Fresh Produce.” Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional 22, no. 4 (June 2016): 353–62. doi:10.1177/1082013215604478. http://www.ncbi.nlm.nih.gov/pubmed/26377335

[33] Desai, Monil A., Kamlesh A. Soni, Ramakrishna Nannapaneni, M. Wes Schilling, and Juan L. Silva. “Reduction of Listeria Monocytogenes Biofilms on Stainless Steel and Polystyrene Surfaces by Essential Oils.” Journal of Food Protection 75, no. 7 (July 2012): 1332–37. doi:10.4315/0362-028X.JFP-11-517. http://www.ncbi.nlm.nih.gov/pubmed/22980020

[34] Deno, Sho, Naohiro Takemoto, and Hiroo Iwata. “Introduction of Antioxidant-Loaded Liposomes into Endothelial Cell Surfaces through DNA Hybridization.” Bioorganic & Medicinal Chemistry 22, no. 1 (January 1, 2014): 350–57. doi:10.1016/j.bmc.2013.11.023. http://www.ncbi.nlm.nih.gov/pubmed/24345482

[35] Ohara, Masaru, and Yoshihiko Ohyama. “Delivery and Application of Dietary Polyphenols to Target Organs, Tissues and Intracellular Organelles.” Current Drug Metabolism 15, no. 1 (January 2014): 37–47. http://www.ncbi.nlm.nih.gov/pubmed/24328691

[36] Kim, Min-Jeong, Marta Mikš-Krajnik, Amit Kumar, Vinayak Ghate, and Hyun-Gyun Yuk. “Antibacterial Effect and Mechanism of High-Intensity 405 ± 5 Nm Light Emitting Diode on Bacillus Cereus, Listeria Monocytogenes, and Staphylococcus Aureus under Refrigerated Condition.” Journal of Photochemistry and Photobiology. B, Biology 153 (December 2015): 33–39. doi:10.1016/j.jphotobiol.2015.08.032. http://www.ncbi.nlm.nih.gov/pubmed/26398810

[37] Ghate, Vinayak, Ai Ling Leong, Amit Kumar, Woo Suk Bang, Weibiao Zhou, and Hyun-Gyun Yuk. “Enhancing the Antibacterial Effect of 461 and 521 Nm Light Emitting Diodes on Selected Foodborne Pathogens in Trypticase Soy Broth by Acidic and Alkaline pH Conditions.” Food Microbiology 48 (June 2015): 49–57. doi:10.1016/j.fm.2014.10.014. http://www.ncbi.nlm.nih.gov/pubmed/25790991

[38] Godshall, Casey E., Gina Suh, and Bennett Lorber. “Cutaneous Listeriosis.” Journal of Clinical Microbiology 51, no. 11 (November 2013): 3591–96. doi:10.1128/JCM.01974-13. http://www.ncbi.nlm.nih.gov/pubmed/23966491

[39] F. H. Mustafa, M. S. Jaafar. “Comparison of Wavelength-Dependent Penetration Depths of Lasers in Different Types of Skin in Photodynamic Therapy.” Indian Journal of Physics 87, no. 3 (2012). doi:10.1007/s12648-012-0213-0. https://www.researchgate.net/publication/234720204_Comparison_of_wavelength-dependent_penetration_depths_of_lasers_in_different_types_of_skin_in_photodynamic_therapy

[40] M Sandasi, C. M. Leonard. “The in Vitro Antibiofilm Activity of Selected Culinary Herbs and Medicinal Plants against Listeria Monocytogenes.” Letters in Applied Microbiology 50, no. 1 (2009): 30–35. doi:10.1111/j.1472-765X.2009.02747.x. https://www.researchgate.net/publication/38052994_The_in_vitro_antibiofilm_activity_of_selected_culinary_herbs_and_medicinal_plants_against_Listeria_monocytogenes

[41] Lee, Sun-Young, So-Young Gwon, Seung-Ju Kim, and Bo Kyung Moon. “Inhibitory Effect of Commercial Green Tea and Rosemary Leaf Powders on the Growth of Foodborne Pathogens in Laboratory Media and Oriental-Style Rice Cakes.” Journal of Food Protection 72, no. 5 (May 2009): 1107–11. http://www.ncbi.nlm.nih.gov/pubmed/19517743

[42] Kohda, Chikara, Yoko Yanagawa, and Tadakatsu Shimamura. “Epigallocatechin Gallate Inhibits Intracellular Survival of Listeria Monocytogenes in Macrophages.” Biochemical and Biophysical Research Communications 365, no. 2 (January 11, 2008): 310–15. doi:10.1016/j.bbrc.2007.10.190. http://www.ncbi.nlm.nih.gov/pubmed/17996193

[43] Ito, M., et al. “Inhibitory Effect of Liposome-Encapsulated Penicillin G on Growth of Listeria Monocytogenes in Mouse Macrophages.”  http://www.ncbi.nlm.nih.gov/pubmed/3103258

[44] Sadekuzzaman, M., S. Yang, M.f.r. Mizan, and S.d. Ha. “Current and Recent Advanced Strategies for Combating Biofilms.” Comprehensive Reviews in Food Science and Food Safety 14, no. 4 (July 1, 2015): 491–509. doi:10.1111/1541-4337.12144. http://onlinelibrary.wiley.com/doi/10.1111/1541-4337.12144/pdf

[45] DC, Carolyn McMakin MA. Frequency Specific Microcurrent in Pain Management, 1e. 1 Pap/Dvdr edition. Edinburgh ; New York: Churchill Livingstone, 2011.

[46] Kose, Adem, and Yusuf Yakupogullari. “A Rapidly Fatal Sepsis Caused by Listeria Monocytogenes Type-4b in a Patient with Chronic Renal Failure.” Jundishapur Journal of Microbiology 8, no. 3 (March 2015): e19980. doi:10.5812/jjm.19980. http://www.ncbi.nlm.nih.gov/pubmed/25969704

[47] Regan, Tim, Ken Nally, Ruaidhri Carmody, Aileen Houston, Fergus Shanahan, John Macsharry, and Elizabeth Brint. “Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria Monocytogenes in Intestinal Epithelial Cells and Macrophages.” Journal of Immunology (Baltimore, Md.: 1950) 191, no. 12 (December 15, 2013): 6084–92. doi:10.4049/jimmunol.1203245. http://www.ncbi.nlm.nih.gov/pubmed/24198280

[48] Kernbauer, Elisabeth, Verena Maier, Isabella Rauch, Mathias Müller, and Thomas Decker. “Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to Listeria Monocytogenes.” PloS One 8, no. 6 (2013): e65007. doi:10.1371/journal.pone.0065007. http://www.ncbi.nlm.nih.gov/pubmed/23840314

[49] Vázquez-Boland, et al. “Listeria Pathogenesis and Molecular Virulence Determinants.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88991/#

[50] Medina, Eduardo, Concepción Romero, Manuel Brenes, and Antonio De Castro. “Antimicrobial Activity of Olive Oil, Vinegar, and Various Beverages against Foodborne Pathogens.” Journal of Food Protection 70, no. 5 (May 2007): 1194–99. http://www.ncbi.nlm.nih.gov/pubmed/17536679

[51] Castillo, Yussaira, Masato Tachibana, Yukiko Nakatsu, Kenta Watanabe, Takashi Shimizu, and Masahisa Watarai. “Combination of Zinc and All-Trans Retinoic Acid Promotes Protection against Listeria Monocytogenes Infection.” PloS One 10, no. 9 (2015): e0137463. doi:10.1371/journal.pone.0137463. http://www.ncbi.nlm.nih.gov/pubmed/26351852

[52] Hap, S., and N. A. Gutierrez. “Functional Properties of Some New Zealand Fruit Extracts towards Selected Probiotic and Pathogenic Bacteria.” Beneficial Microbes 3, no. 4 (December 1, 2012): 309–18. doi:10.3920/BM2012.0004. http://www.ncbi.nlm.nih.gov/pubmed/22968373

[53] Uymaz, Başar, Nefise Akkoç, and M. Akçelik. “Partial Characterization of Bacteriocins Produced by Two Lactobacilus Strains with Probiotic Properties.” Acta Biologica Hungarica 62, no. 1 (March 2011): 95–105. doi:10.1556/ABiol.61.2011.1.10. http://www.ncbi.nlm.nih.gov/pubmed/21388923

[54] Corr, Sinead C., Cormac G. M. Gahan, and Colin Hill. “Impact of Selected Lactobacillus and Bifidobacterium Species on Listeria Monocytogenes Infection and the Mucosal Immune Response.” FEMS Immunology and Medical Microbiology 50, no. 3 (August 2007): 380–88. doi:10.1111/j.1574-695X.2007.00264.x. http://www.ncbi.nlm.nih.gov/pubmed/17537177

[55] Pavia, Charles S., Cynthia M. Harris, and Marie Kavanagh. “Impaired Bactericidal Activity and Host Resistance to Listeria Monocytogenes and Borrelia Burgdorferi in Rats Administered an Acute Oral Regimen of Ethanol.” Clinical and Diagnostic Laboratory Immunology 9, no. 2 (March 2002): 282–86. doi:10.1128/CDLI.9.2.282-286.2002. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC119923/

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May 1 16

Why You Need These Four Essential Oils for Relieving Lyme Disease Insomnia and Brain Fog caused by Toxic Sinuses

by Greg

Ernie_Banks_gum

For people with Lyme disease who have brain fog and insomnia due to toxic sinus infections
by Greg Lee

 

I loved collecting baseball cards as a kid. When I opened a new pack of cards, I was always filled with excited thoughts of, “Will I get a Willie Mays or a Hank Aaron?” And sometimes I only got cards that I already had multiple copies of, bless you Bob Burda. After finding out which cards I received, I got to enjoy a big pink stick of bubble gum. I got in big trouble once, when I put the gum in my pocket and it ended up going through the washer. Many of the other clothes ended up being stuck to pink gooey gum.

 

How is melted bubble gum that sticks to your clothes similar to toxic sinus infections in people with Lyme?

 

Just like gooey bubble gum, toxic infections can get stuck in the sinuses
In multiple studies, people with chronic sinus irritation have tested positive for a variety of different infections including: Staphylococcus aureus[1], Staphylococcus epidermidis[2], Streptococcus intermedius[3], Chlamydia[4], Clostridia[5], Mycoplasma[6], Nocardia nova[7], Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes, and anaerobic organisms: Prevotella and Porphyromonas, Fusobacterium, and Peptostreptococcus spp.[8] In immune compromised patients, multiple infections have detected including: Alternaria alternata[9], Aspergillus flavus[10], Mucormycetes[11], Fusarium[12], Cytomegalovirus[13], Bordetella petrii[14], Escherichia coli, Stenotrophomonas maltophilia, and basidiomycetous fungi (Schizophyllum commune)[15]. In rare cases, unusual infections that are mostly found in animals or soil have also been detected in sinus infections like: Staphylococcus pseudintermedius[16], and Paecilomyces variotii[17]. In other studies, dental infections have also been found to invade the sinuses[18]. Inflammatory markers can help to identify the types of infections in the sinus.

 

Inflammatory markers can give a clue to bacterial and fungal sinus infections
In sinus patients infected with Aspergillus and Alternaria, interleukin (IL)- 2, IL-4, IL-5, IL-10, tumor necrosis factor α, and interferon-γ were elevated[19]. Another study on chronic bacterial sinus infection patients showed that inflammatory markers IL-4, IL-8, IL-13 and Myeloperoxidase (MPO) were higher in the upper airway compared to the lower airway[20]. Sinus infections can also produce chronic physical problems and difficult emotions.

 

Sinus infections can affect physical as well as emotional symptoms
Severe sinus infections produce toxins which triggers inflammation and can lead to complications like irritability, decreased attention, anxiety, insomnia, depression[21], meningitis, abscesses in the brain[22], paralysis, tremors, weakness, blindness[23], sepsis[24], cerebral aneurysm[25], stroke[26], and death[27]. Elevated inflammatory compounds: IL-1β, IL-6, IL-8, and IL-13 were correlated with sleep disturbance and depression and may be an indicator of the severity of a sinus infection[28]. Unfortunately, these infections have multiple defense mechanisms to help them persist in the sinuses.

 

Toxic sinus infections can survive longer by hiding under multiple defenses
Sinus infections can be characterized by local inflammation, mucus discharge, immunoglobulin deficiency[29], pus, cysts, or polyps[30]. Sinus polyps have been found to have high levels of fibrin[31], which can isolate infections from your immune system and medications. Biofilms[32] are a slime produced by many different infections to protect against antimicrobial drugs, the killer cells of the immune system, and against other pathogens. Biofilms can increase drug resistance by a factor of ten to a thousand fold[33]. Biofilms are believed to be a main cause of recurring sinus infections that persist despite surgeries, multiple rounds of antibiotics or antifungals[34]. One study identifies nasal cysts, polyps, and mucus as likely places where infections can survive despite intravenous antibiotic treatment[35]. Unfortunately, patients with Lyme disease have also been found to have drug-resistant Staph bacteria.

 

Drug resistant Staph bacterial have been detected in the sinuses of Lyme patients receiving antibiotic treatment
Dr. Ritchie Shoemaker has found Multiple Antibiotic Resistant Coagulase Negative Staph (MARCoNS) infections in the sinuses of his patients receiving antibiotic treatment[36]. His protocol uses a nasal spray consisting of antibiotics along with biofilm dissolving EDTA. Unfortunately, the majority of health care providers treating Lyme patients are not following Dr. Shoemaker’s protocol.

 

What else can help people with Lyme disease to fight drug-resistant, biofilm forming, multi-species sinus infections?

 

Here are four essential oils that are effective at inhibiting infections and inflammatory compounds found in sinus infections
Fortunately, there are essential oils that have been found to inhibit many of the infections and biofilms that infect the sinuses and have also been effective at relieving pain, sleep problems, and difficult emotions. Preparing the remedies in a micronized form called a liposome, which are microscopic particles of medicinal oils that are wrapped in a lipid, increases their penetration into tissues and their antimicrobial, antibiofilm properties[37]. Which is why liposomal remedies may be highly effective at helping patients with penetrating into and eliminating persistent sinus infections and accompanying symptoms.

 

Sinus Infection Essential Oil #1: Tea Tree
In one wound study, liposomal tea tree oil combined with silver ions was effective at inhibiting Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans[38]. Tea Tree essential oil was also effective a reducing the size of wounds caused by methicillin-resistant Staphylococcus aureus (MRSA)[39]. Tea tree oil was also effective against Staphylococcus epidermidis, Escherichia coli, Saccharomyces cerevisiae[40], antibiotic resistant Candida spp.[41], Pseudomonas aeruginosa and its biofilm,[42] Aspergillus niger, Aspergillus flavus[43], Aspergillus fumigatus, Penicillium chrysogenum[44], Mycoplasma pneumoniae, Mycoplasma hominis and Mycoplasma fermentans[45], group A streptococcus[46], Fusarium graminearum, Fusarium culmorum, Pyrenophora graminea[47], Alternaria alternata, Botrytis cinerea and Fusarium oxysporum[48] in lab and animal studies.

 

In response to bacterial endotoxins, tea tree essential oil was effective at lowering inflammatory compounds IL-1β, IL-6 and IL-10[49]. In another lab study, tea tree oil decreased IL-2 and increased anti-inflammatory compound IL-4[50]. Caution: some cases have been reported where tea tree oil caused allergic dermatitis when placed on the skin[51]. In five cases, high doses of this oil internally, 0.5-1.0 ml/kg, have produced central nervous system symptoms of loss of coordination, drowsiness, unconsciousness, diarrhea, and abdominal pain[52]. In addition to tea tree oil, cinnamon has excellent antimicrobial properties.

 

Sinus Infection Essential Oil #2: Cinnamon Bark 
In unpublished lab research, cinnamon essential oil was effective at cutting through the Lyme biofilm and killing the bacteria. This oil is also effective at inhibiting: multi-drug resistant Pseudomonas aeruginosa and Escherichia coli toxin production and biofilms[53], multi-drug resistant strains of Salmonella typhi, Salmonella paratyphi A, Escherichia coli, Staphylococcus aureus, Pseudomonas fluorescens and Bacillus licheniformis[54], methicillin-resistant Staphylococcus aureus (MRSA)[55], Candida albicans[56], quorum sensing communication in drug resistant Chromobacterium violaceum and Pseudomonas aeruginosa[57], Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes[58], Campylobacter jejuni, Salmonella enteritidis, Listeria monocytogenes[59], Penicillium commune, P. roqueforti, Aspergillus flavus and Endomyces fibuliger[60].

 

In other studies which combine this oil and antibiotics, cinnamon bark essential oil helped to reduce drug resistance in multiple bacterial strains when combined with a beta-lactam antibiotic[61] and had a synergistic effect with gentamicin against multidrug-resistant Acinetobacter spp.[62]. Cinnamon oil has produced allergic dermatitis in some cases when placed on the skin. This oil may interfere with blood clotting. In one case, a boy drank 60 ml of cinnamon oil upon a dare and experienced symptoms of burning sensation in the mouth, chest and stomach, dizziness, double vision, nausea, vomiting and later collapse[63]. Another promising sinus antimicrobial remedy is thyme oil.

 

Sinus Infection Essential Oil #3: Thyme 
Thyme essential oil has been shown to inhibit Methicillin resistant Staphylococcus aureus (MRSA)[64], Staphylococcus aureus biofilms[65], Antibiotic-Resistant Candida spp.[66], Vancomycin-Resistant Enterococci[67], drug-resistant strains of Aspergillus spp. and Trichophyton rubrum[68],  Clostridium perfringens, Campylobacter jejuni[69], Listeria monocytogenes, Salmonella Typhimurium, enterohemorrhagic Escherichia coli, Brochothrix thermosphacta, Pseudomonas fluorescens[70], Zygosaccharomyces bailii[71], Staphylococcus, Enterococcus, Escherichia, Pseudomonas genera[72], Aeromonas species[73], Haemophilus influenzae, Streptococcus pneumoniae, and Streptococcus pyogenes[74].

 

In one mouse colitis experiment, thyme oil combined with oregano essential oil was effective at lowering IL-1beta, IL-6, GM-CSF, and TNFalpha[75]. Caution: thyme oil (geraniol chemotype) should not be taken in people with obstructed bile flow[76]. In addition to thyme, lemongrass has antimicrobial and antibiofilm properties.

 

Sinus Infection Essential Oil #4: Lemongrass 
Lemongrass essential oil has inhibited Staphylococcus aureus biofilms[77], drug-resistant strains of Actinomyces naeslundii, Porphyromonas gingivalis[78], methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), multi-drug resistant Pseudomonas aeruginosa, ESBL-producing Escherichia coli, Klebsiella pneumoniae[79], multi-drug resistant Candida albicans[80], multi-drug resistant strains of Streptococcus and Candida[81], and the Aeromonas hydrophyla biofilm[82].

 

Vaporized lemongrass oil combined with geranium oil inhibited MRSA, vancomycin-resistant Enterococci (VRE), Acinetobacter baumanii and Clostridium difficile[83]. Lemongrass oil followed by clove oil was highly effective against Candida albicans and its biofilms[84]. In one lab study, lemongrass oil inhibited the production of IL-1beta and IL-6[85]. Using multiple essential oils in combination can help with reducing chronic sinus infection symptoms.

 

Essential oils in combination can help to resolve chronic sinus infection symptoms in people with Lyme
Similar to getting sticky bubble gum off a bunch of clothes, essential oils can help people with Lyme to reduce sinus infection symptoms. Combining these oils can enhance their antimicrobial and antibiofilm properties. Patients that take these oils in a carrier oil under their tongue report reduced inflammation, improved sleep, and less brain fog. When encapsulated into a micronized particle called a liposome, these oils may be capable of even greater penetration into the sinus tissues when held in the mouth. In addition to inhibiting multiple harmful bacteria and fungi, these oils may also help with relieving uncomfortable emotions that are associated with elevated toxins and inflammation. Since some of these essential oils have cautions on their use, work with a Lyme literate essential oil practitioner to develop a proper, safe, and effective strategy for your condition.

 

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday June 6th at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing from Lyme disease and co-infection symptoms.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to overcome insomnia and brain fog caused by a toxic sinus infection? Tell us about it.



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[50] Caldefie-Chézet, F., C. Fusillier, T. Jarde, H. Laroye, M. Damez, M.-P. Vasson, and J. Guillot. “Potential Anti-Inflammatory Effects of Melaleuca Alternifolia Essential Oil on Human Peripheral Blood Leukocytes.” Phytotherapy Research: PTR 20, no. 5 (May 2006): 364–70. doi:10.1002/ptr.1862. http://www.ncbi.nlm.nih.gov/pubmed/16619364
[51] Tisserand, Robert, and Rodney Young. Essential Oil Safety p. 1495.502-1503
[52] Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. Elsevier Health Sciences, 2013. pp. 1502-1503
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[55] Horváth, Györgyi, Noémi Jámbor, Erika Kocsis, Andrea Böszörményi, Eva Lemberkovics, Eva Héthelyi, Krisztina Kovács, and Béla Kocsis. “Role of Direct Bioautographic Method for Detection of Antistaphylococcal Activity of Essential Oils.” Natural Product Communications 6, no. 9 (September 2011): 1379–84. http://www.ncbi.nlm.nih.gov/pubmed/21941919
[56] Carvalhinho, Sara, Ana Margarida Costa, Ana Cláudia Coelho, Eugénio Martins, and Ana Sampaio. “Susceptibilities of Candida Albicans Mouth Isolates to Antifungal Agents, Essentials Oils and Mouth Rinses.” Mycopathologia 174, no. 1 (July 2012): 69–76. doi:10.1007/s11046-012-9520-4. http://www.ncbi.nlm.nih.gov/pubmed/22246961
[57] Khan, M. S. A., M. Zahin, S. Hasan, F. M. Husain, and I. Ahmad. “Inhibition of Quorum Sensing Regulated Bacterial Functions by Plant Essential Oils with Special Reference to Clove Oil.” Letters in Applied Microbiology 49, no. 3 (September 2009): 354–60. doi:10.1111/j.1472-765X.2009.02666.x. http://www.ncbi.nlm.nih.gov/pubmed/19627477
[58] Inouye, S., H. Yamaguchi, and T. Takizawa. “Screening of the Antibacterial Effects of a Variety of Essential Oils on Respiratory Tract Pathogens, Using a Modified Dilution Assay Method.” Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy 7, no. 4 (December 2001): 251–54. doi:10.1007/s101560100045. http://www.ncbi.nlm.nih.gov/pubmed/11810593
[59] Smith-Palmer, A., J. Stewart, and L. Fyfe. “Antimicrobial Properties of Plant Essential Oils and Essences against Five Important Food-Borne Pathogens.” Letters in Applied Microbiology 26, no. 2 (February 1998): 118–22. http://www.ncbi.nlm.nih.gov/pubmed/9569693
[60] Nielsen, P. V., and R. Rios. “Inhibition of Fungal Growth on Bread by Volatile Components from Spices and Herbs, and the Possible Application in Active Packaging, with Special Emphasis on Mustard Essential Oil.” International Journal of Food Microbiology 60, no. 2–3 (September 25, 2000): 219–29. http://www.ncbi.nlm.nih.gov/pubmed/11016611
[61] Yap, Polly Soo Xi, Swee Hua Erin Lim, Cai Ping Hu, and Beow Chin Yiap. “Combination of Essential Oils and Antibiotics Reduce Antibiotic Resistance in Plasmid-Conferred Multidrug Resistant Bacteria.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 20, no. 8–9 (June 15, 2013): 710–13. doi:10.1016/j.phymed.2013.02.013. http://www.ncbi.nlm.nih.gov/pubmed/23537749
[62] Guerra, Felipe Queiroga Sarmento, Juliana Moura Mendes, Janiere Pereira de Sousa, Maria F. B. Morais-Braga, Bernadete Helena Cavalcante Santos, Henrique Douglas Melo Coutinho, and Edeltrudes de Oliveira Lima. “Increasing Antibiotic Activity against a Multidrug-Resistant Acinetobacter Spp by Essential Oils of Citrus Limon and Cinnamomum Zeylanicum.” Natural Product Research 26, no. 23 (2012): 2235–38. doi:10.1080/14786419.2011.647019. http://www.ncbi.nlm.nih.gov/pubmed/22191514
[63] Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. Elsevier Health Sciences, 2013. p. 890.
[64] Tohidpour, A., M. Sattari, R. Omidbaigi, A. Yadegar, and J. Nazemi. “Antibacterial Effect of Essential Oils from Two Medicinal Plants against Methicillin-Resistant Staphylococcus Aureus (MRSA).” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 17, no. 2 (February 2010): 142–45. doi:10.1016/j.phymed.2009.05.007. http://www.ncbi.nlm.nih.gov/pubmed/19576738
[65] Vázquez-Sánchez, Daniel, Marta L. Cabo, and Juan J. Rodríguez-Herrera. “Antimicrobial Activity of Essential Oils against Staphylococcus Aureus Biofilms.” Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional 21, no. 8 (December 2015): 559–70. doi:10.1177/1082013214553996. http://www.ncbi.nlm.nih.gov/pubmed/25280938
[66] Rajkowska, Katarzyna, Alina Kunicka-Styczyńska, and Marta Maroszyńska. “Selected Essential Oils as Antifungal Agents Against Antibiotic-Resistant Candida Spp.: In Vitro Study on Clinical and Food-Borne Isolates.” Microbial Drug Resistance (Larchmont, N.Y.), April 19, 2016. doi:10.1089/mdr.2016.0001. http://www.ncbi.nlm.nih.gov/pubmed/27092733
[67] Selim, Samy. “Antimicrobial Activity of Essential Oils against Vancomycin-Resistant Enterococci (vre) and Escherichia Coli o157:h7 in Feta Soft Cheese and Minced Beef Meat.” Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology] 42, no. 1 (January 2011): 187–96. doi:10.1590/S1517-83822011000100023. http://www.ncbi.nlm.nih.gov/pubmed/24031620
[68] Khan, Mohd Sajjad Ahmad, Iqbal Ahmad, and Swaranjit Singh Cameotra. “Carum Copticum and Thymus Vulgaris Oils Inhibit Virulence in Trichophyton Rubrum and Aspergillus Spp.” Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology] 45, no. 2 (2014): 523–31. http://www.ncbi.nlm.nih.gov/pubmed/25242937
[69] Kovács, Judit K., Györgyi Horváth, Monika Kerényi, Béla Kocsis, Levente Emődy, and György Schneider. “A Modified Bioautographic Method for Antibacterial Component Screening against Anaerobic and Microaerophilic Bacteria.” Journal of Microbiological Methods 123 (April 2016): 13–17. doi:10.1016/j.mimet.2016.02.006. http://www.ncbi.nlm.nih.gov/pubmed/26853123
[70] Mith, Hasika, Rémi Duré, Véronique Delcenserie, Abdesselam Zhiri, Georges Daube, and Antoine Clinquart. “Antimicrobial Activities of Commercial Essential Oils and Their Components against Food-Borne Pathogens and Food Spoilage Bacteria.” Food Science & Nutrition 2, no. 4 (July 2014): 403–16. doi:10.1002/fsn3.116. http://www.ncbi.nlm.nih.gov/pubmed/25473498
[71] Chang, Yuhua, Lynne McLandsborough, and David Julian McClements. “Physical Properties and Antimicrobial Efficacy of Thyme Oil Nanoemulsions: Influence of Ripening Inhibitors.” Journal of Agricultural and Food Chemistry 60, no. 48 (December 5, 2012): 12056–63. doi:10.1021/jf304045a. http://www.ncbi.nlm.nih.gov/pubmed/23140446
[72] Sienkiewicz, Monika, Monika Łysakowska, Julita Ciećwierz, Paweł Denys, and Edward Kowalczyk. “Antibacterial Activity of Thyme and Lavender Essential Oils.” Medicinal Chemistry (Shāriqah (United Arab Emirates)) 7, no. 6 (November 2011): 674–89. http://www.ncbi.nlm.nih.gov/pubmed/22313307
[73] Uyttendaele, M., K. Neyts, H. Vanderswalmen, E. Notebaert, and J. Debevere. “Control of Aeromonas on Minimally Processed Vegetables by Decontamination with Lactic Acid, Chlorinated Water, or Thyme Essential Oil Solution.” International Journal of Food Microbiology 90, no. 3 (February 1, 2004): 263–71. http://www.ncbi.nlm.nih.gov/pubmed/14751681
[74] Inouye, S., H. Yamaguchi, and T. Takizawa. “Screening of the Antibacterial Effects of a Variety of Essential Oils on Respiratory Tract Pathogens, Using a Modified Dilution Assay Method.” http://www.ncbi.nlm.nih.gov/pubmed/11810593
[75] Bukovská, Alexandra, Stefan Cikos, Stefan Juhás, Gabriela Il’ková, Pavol Rehák, and Juraj Koppel. “Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice.” Mediators of Inflammation 2007 (2007): 23296. doi:10.1155/2007/23296. http://www.ncbi.nlm.nih.gov/pubmed/18288268
[76] Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. Elsevier Health Sciences, 2013. p. 1518.
[77] Vázquez-Sánchez, Daniel, Marta L. Cabo, and Juan J. Rodríguez-Herrera. “Antimicrobial Activity of Essential Oils against Staphylococcus Aureus Biofilms.” Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional 21, no. 8 (December 2015): 559–70. doi:10.1177/1082013214553996.
[78] Warad, Shivaraj B., Sahana S. Kolar, Veena Kalburgi, and Nagaraj B. Kalburgi. “Lemongrass Essential Oil Gel as a Local Drug Delivery Agent for the Treatment of Periodontitis.” Ancient Science of Life 32, no. 4 (April 2013): 205–11. doi:10.4103/0257-7941.131973. http://www.ncbi.nlm.nih.gov/pubmed/24991068
[79] Warnke, Patrick H., Alexander J. S. Lott, Eugene Sherry, Joerg Wiltfang, and Rainer Podschun. “The Ongoing Battle against Multi-Resistant Strains: In-Vitro Inhibition of Hospital-Acquired MRSA, VRE, Pseudomonas, ESBL E. Coli and Klebsiella Species in the Presence of Plant-Derived Antiseptic Oils.” Journal of Cranio-Maxillo-Facial Surgery: Official Publication of the European Association for Cranio-Maxillo-Facial Surgery 41, no. 4 (June 2013): 321–26. doi:10.1016/j.jcms.2012.10.012. http://www.ncbi.nlm.nih.gov/pubmed/23199627
[80] Khan, Mohd Sajjad Ahmad, Abida Malik, and Iqbal Ahmad. “Anti-Candidal Activity of Essential Oils Alone and in Combination with Amphotericin B or Fluconazole against Multi-Drug Resistant Isolates of Candida Albicans.” Medical Mycology 50, no. 1 (January 2012): 33–42. doi:10.3109/13693786.2011.582890. http://www.ncbi.nlm.nih.gov/pubmed/21756200
[81] Warnke, Patrick H., Stephan T. Becker, Rainer Podschun, Sureshan Sivananthan, Ingo N. Springer, Paul A. J. Russo, Joerg Wiltfang, Helmut Fickenscher, and Eugene Sherry. “The Battle against Multi-Resistant Strains: Renaissance of Antimicrobial Essential Oils as a Promising Force to Fight Hospital-Acquired Infections.” Journal of Cranio-Maxillo-Facial Surgery: Official Publication of the European Association for Cranio-Maxillo-Facial Surgery 37, no. 7 (October 2009): 392–97. doi:10.1016/j.jcms.2009.03.017. http://www.ncbi.nlm.nih.gov/pubmed/19473851
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Apr 25 16

Essential Oils for Healing Persistent Lyme Symptoms Online Six Week Training

by Greg

herbs_essential_oils
ONLINE Live Six Week Training: Essential Oils for Healing Persistent Lyme Symptoms for Medical Providers

Learn to Reduce Persistent Symptoms Faster in Your Lyme Disease Patients Through Essential Oils

– Do you have Lyme patients that continue to report recurring pain, fatigue and mental fog?

– Are you frustrated by the lack of patient improvement with
Lyme protocols?

– Learn about safe amounts of essential oils for internal use
to treat stubborn Lyme symptoms.

Sign up by April 28th and receive a BONUS cold laser and an essential oil remedy laser kit for Lyme and other infection symptoms worth $100.

Participants will get six one-hour live training sessions every Friday 3pm – 4pm EST from April 29th – June 3rd. All sessions are recorded and available for replay 24/7. Participants will also get bonus videos on using cold laser essential oils and making liposomal essential oil remedies for resolving persistent Lyme symptoms.

You can see two videos, one on specific essential oils for Lyme and co-infections and a second of an indepth case study on how oils helped heal neurological Lyme disease and co-infections here:

Training

Registration closes Thursday April 28th. Space is limited…
This training costs $900, which is 25% off the cost of the live event.

Questions about the training?
Please email me at TwoFrogsHealingCenter at gmail.com

– Greg

Apr 3 16

Can These Three Sweets Help You to Heal Lyme Disease?

by Greg

house_of_cards
For people with Lyme disease and co-infections who crave sweets and carbohydrates
by Greg Lee

Have you ever been glued to watching your favorite TV series? I’m often left with more questions at the end of an episode of House of Cards. Has Frank gone to far? Will this finally be his downfall? What will be the backlash of losing a hostage? My brain goes round and round with what might happen next season.

How is thinking about a captivating TV series similar to food cravings in people with Lyme disease?

Just like the drama in a popular TV series, people with Lyme disease can have unstoppable cravings for sweets
Many patients diagnosed with Lyme disease report craving carbohydrates, gluten-rich foods, sugar, and sweet fruits. They go back and forth with thoughts like, “Eat the ice cream, you deserve a treat!” “Don’t eat the ice cream, it’s bad for you.” Many of these people report an increase in their symptoms after giving in to the “EAT IT!” voice. Multiple studies correlate similar types of cravings with decreased levels of serotonin[1], melatonin[2], leptin[3], or dopamine[4]. Patients diagnosed with Lyme, co-infections, or mold can have lowered levels of serotonin[5], melatonin[6], or dopamine[7]. Unfortunately, these people can have difficulty overcoming their cravings.

People with Lyme disease often need more than dietary restrictions to overcome cravings
Most Lyme diet guideline tell people to avoid dairy, gluten, and refined sugars. These foods can increase inflammation which may increase symptoms of fatigue, brain fog, and pain. However, these restrictive diets often increase the intensity of cravings in patients which often leads to an inability to stick to the “recommended” foods. If the craving for carbs and sweets is related to an underlying deficiency, then increasing the deficient compound(s) could effectively reduce or eliminate the cravings.

What else beside dietary recommendations can help people with Lyme disease to stop cravings and fight infections?

These three sweets help reduce cravings and support the immune system to fight Lyme disease
Studies on obesity often recommend healthier replacements like stevia and xylitol in place of artificial sweeteners or refined sugars which people have become addicted to[8]. Fortunately, these sweeteners can reduce cravings and can help people to fight infections. These and other sweeteners can protect vital organs from toxic compounds and enhance the neurological functioning. Processing these sweeteners into a micronized particle called a liposome, enhances their delivery inside cells[9], into the nervous system[10], and into biofilms[11].

Lyme Healing Sweetener #1: Stevia
A big challenge in experiments is how to kill persistent “antibiotic resistant” forms of the Lyme bacteria. In one experiment, whole leaf extract of stevia was effective in eliminating persistent forms of Lyme as well as biofilms that they hide under[12]. In another study, it lowers blood glucose and serum triglyceride levels[13]. Other studies indicate that stevia has anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory effects[14]. In addition to stevia, xylitol is a natural sweetener with additional healing properties for people with Lyme.

Lyme Healing Sweetener #2: Xylitol
Xylitol has shown in multiple animal and lab studies to inhibit different microbes including: H1N1[15], Streptococcus mutans and it’s biofiims[16], and Streptococcus pneumoniae[17]. It also has a bacteriostatic effect on Listeria Monocytogenes[18]. This sweetener also had a protective effect against Clostridium difficile in a mouse study[19]. Xylitol inhibits multiple oral biofilms in lab studies[20]. When combined with lactoferrin and silver, xylitol has enhanced anti-biofilm properties in wound healing studies[21]. A third sweetener, royal jelly can help with healing the damaging effects of Lyme.

Lyme Healing Sweetener #3: Royal Jelly
Royal jelly (RJ) is the food that is given to queen honey bees and larvae. Since the only way to develop queen bees is to continually feed them RJ, this sweetener enhances the genetic expression of larvae[22]. In one study, RJ had antifungal activity against Candida species[23]. In another study, RJ has been demonstrated to possess numerous functional properties such as antibacterial activity, anti-inflammatory activity, vasodilative and hypotensive activities, disinfectant action, antioxidant activity, antihypercholesterolemic activity, and antitumor activity[24].

In one study, RJ protected mice embryos from toxic oxymetholone[25]. In another mouse study, RJ enhanced bone regeneration[26]. In another rat study, RJ protected the colon against chemically induced colitis[27]. It also protected rats against chemotherapy kidney injury in another study[28].

Another study on rat pup brains showed how RJ increased gamma amino butyric acid (GABA), dopamine, and serotonin levels in response to toxic tartrazine[29]. Bees fed tyrosine, a compound in RJ, had increased levels of dopamine[30]. Rats with chemically induced brain injury, had greater memory recall and spatial learning when fed RJ[31]. In another experiment, RJ facilitated the differentiation of different neural cells and it’s compound HDEA facilitated neural growth[32]. RJ is most commonly mixed with honey. One caution, some people may have an allergic reaction to royal jelly. The sweeteners provide a sweet answer to food cravings in patients with Lyme and co-infections.

These sweeteners can help people with Lyme disease to stop food cravings by increasing deficient neurological compounds
Just like watching the “reveal all” episode that stops the obsessive thinking about the characters in a TV series, these sweeteners can be helpful at resolving food cravings by satisfying the underlying deficiencies in neurological compounds like dopamine and serotonin. These sweeteners can also help people to fight stealthy forms of infections, penetrate biofilms, and reduce the damaging effects of Lyme and co-infections. When encapsulated into a liposome, these sweeteners may have even greater penetration into the places where germs hide and provide deeper protection for the brain and other vital organs. Since some of these sweeteners have cautions on their use, work with a Lyme literate herbal practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

Next step: Come to our evening lecture Getting Rid of Lyme Disease in Frederick, Maryland on Monday April 4th at 6pm to learn more about sweeteners, herbs, and essential oils for protecting yourself from Lyme disease and co-infections.

http://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where sweeteners helped you to fight and heal Lyme disease and co-infections? Tell us about it.


[1] Shabbir, Faisal, Akash Patel, Charles Mattison, Sumit Bose, Raathathulaksi Krishnamohan, Emily Sweeney, Sarina Sandhu, et al. “Effect of Diet on Serotonergic Neurotransmission in Depression.” Neurochemistry International 62, no. 3 (February 2013): 324–29. doi:10.1016/j.neuint.2012.12.014. http://www.ncbi.nlm.nih.gov/pubmed/23306210
[2] Sandyk, R. “Treatment with Weak Electromagnetic Fields Attenuates Carbohydrate Craving in a Patients with Multiple Sclerosis.” The International Journal of Neuroscience 86, no. 1–2 (July 1996): 67–77. http://www.ncbi.nlm.nih.gov/pubmed/8828061
[3] Licinio, J., A. B. Negrao, and M.-L. Wong. “Plasma Leptin Concentrations Are Highly Correlated to Emotional States throughout the Day.” Translational Psychiatry 4 (2014): e475. doi:10.1038/tp.2014.115. http://www.ncbi.nlm.nih.gov/pubmed/25350298
[4] Blum, Kenneth, Panayotis K. Thanos, and Mark S. Gold. “Dopamine and Glucose, Obesity, and Reward Deficiency Syndrome.” Frontiers in Psychology 5 (2014): 919. doi:10.3389/fpsyg.2014.00919. http://www.ncbi.nlm.nih.gov/pubmed/25278909
[5] Bransfield, Robert C., Jeffrey S. Wulfman, William T. Harvey, and Anju I. Usman. “The Association between Tick-Borne Infections, Lyme Borreliosis and Autism Spectrum Disorders.” Medical Hypotheses 70, no. 5 (2008): 967–74. doi:10.1016/j.mehy.2007.09.006. http://www.ncbi.nlm.nih.gov/pubmed/17980971
[6] “The Biotoxin Pathway | Surviving Mold.” Accessed April 3, 2016. http://www.survivingmold.com/diagnosis/the-biotoxin-pathway.
[7] Sava, V., O. Reunova, A. Velasquez, R. Harbison, and J. Sánchez-Ramos. “Acute Neurotoxic Effects of the Fungal Metabolite Ochratoxin-A.” Neurotoxicology 27, no. 1 (January 2006): 82–92. doi:10.1016/j.neuro.2005.07.004. http://www.ncbi.nlm.nih.gov/pubmed/16140385
[8] Bilton, Rod. “Averting Comfortable Lifestyle Crises.” Science Progress 96, no. Pt 4 (2013): 319–68. http://www.ncbi.nlm.nih.gov/pubmed/24547668
[9] Pumerantz A, Muppidi K, Agnihotri S, Guerra C, Venketaraman V, Wang J, Betageri G. Preparation of liposomal vancomycin and intracellular killing of meticillin-resistant Staphylococcus aureus (MRSA). Int J Antimicrob Agents. 2011 Feb;37(2):140-4. doi: 10.1016/j.ijantimicag.2010.10.011. Epub 2010 Dec 3. http://www.ncbi.nlm.nih.gov/pubmed/21130608
[10] Alhariri M, Azghani A, Omri A. Liposomal antibiotics for the treatment of infectious diseases. Expert Opin Drug Deliv. 2013 Nov;10(11):1515-32. doi: 10.1517/17425247.2013.822860. Epub 2013 Jul 26. http://www.ncbi.nlm.nih.gov/pubmed/23886421
[11] Jones, Malcolm N. “Use of Liposomes to Deliver Bactericides to Bacterial Biofilms.” Methods in Enzymology 391 (2005): 211–28. doi:10.1016/S0076-6879(05)91013-6. http://www.ncbi.nlm.nih.gov/pubmed/15721384
[12] Theophilus, P. a. S., M. J. Victoria, K. M. Socarras, K. R. Filush, K. Gupta, D. F. Luecke, and E. Sapi. “Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro.” European Journal of Microbiology & Immunology 5, no. 4 (December 2015): 268–80. doi:10.1556/1886.2015.00031. http://www.ncbi.nlm.nih.gov/pubmed/26716015
[13] Ritu, Mathur, and Johri Nandini. “Nutritional Composition of Stevia Rebaudiana- A Sweet Herb and Its Hypoglycaemic and Hypolipidaemic Effect on Patients with Non Insulin Dependent Diabetes Mellitus.” Journal of the Science of Food and Agriculture, January 19, 2016. doi:10.1002/jsfa.7627. http://www.ncbi.nlm.nih.gov/pubmed/26781312
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